International Journal of Ophthalmology & Visual Science

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A Correlative Study of Intra Ocular Pressure, Mean Arterial Pressure and CSF Pressure in Non Neurological Patients

Received: 24 August 2018    Accepted: 11 September 2018    Published: 15 October 2018
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Abstract

Introduction: Blood pressure is one of the most important and most widely studied factors affecting the IOP. Another important factor that plays an important role in pathogenesis of glaucoma is cerebrospinal fluid pressure. The present study was planned to study the relationship between intraocular pressure, mean arterial pressure and estimated Cerebrospinal fluid pressure in non-neurological patients. Material and Method: The present study was conducted in the Department of Ophthalmology. The study was carried out as a case-control study for 18 months. The patients above 40 years of age irrespective of sex were included in the study after their informed consent. Total of 250 patients were taken out of which 150 were cases with signs of glaucoma and 100 were controls with no signs of glaucoma. Result: 250 subjects enrolled in the study, a total of 150 (60%) were clinically established cases of glaucoma (with IOP >22mmHg) and comprised the case group of study whereas remaining 100 were apparently healthy subjects with no signs and symptoms of glaucoma and had IOP <22 mmHg and comprised the control group of the study. Mean ICP values of subjects with IOP 31-40 mm Hg were significantly higher as compared to those with IOP 23-30 mm Hg and ≤22 mmHg respectively (p=0.002). Mean Arterial Pressure (MAP) showed a significant near mild positive correlation with IOP (r=0.288; p<0.001) and a moderate positive correlation with ICP (r=0.520; p<0.001). However, the correlation between IOP and ICP was weak positive but significant (p=0.010). The relationship between gender and mean MAP and IOP and ICP was evaluated, and the values of all of them were higher in males as compared to females, but the difference was significant only for mean IOP and ICP (p=0.180 and p<0.001 respectively). Conclusion: The findings in present study thus indicate that the relationship between IOP, ICP and MAP is governed by a multitude of factors (in present study these covariates were age, gender and BMI). The present study was unique in the sense that it was probably the first Indian study exploring relationship between IOP, MAP and ICP, and that too in healthy individuals.

DOI 10.11648/j.ijovs.20180302.14
Published in International Journal of Ophthalmology & Visual Science (Volume 3, Issue 2, June 2018)
Page(s) 32-38
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Intra Ocular Pressure, Mean Arterial Pressure, Cerebrospinal Fluid Pressure, Non-Neurological Patients

References
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Author Information
  • Department of Ophthalmology, Era’s Lucknow Medical College and Hospital, Lucknow, India

  • Department of Ophthalmology, Era’s Lucknow Medical College and Hospital, Lucknow, India

  • Department of Ophthalmology, Era’s Lucknow Medical College and Hospital, Lucknow, India

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    Pragati Garg, Smriti Diwedi, Ritika Mullick. (2018). A Correlative Study of Intra Ocular Pressure, Mean Arterial Pressure and CSF Pressure in Non Neurological Patients. International Journal of Ophthalmology & Visual Science, 3(2), 32-38. https://doi.org/10.11648/j.ijovs.20180302.14

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    ACS Style

    Pragati Garg; Smriti Diwedi; Ritika Mullick. A Correlative Study of Intra Ocular Pressure, Mean Arterial Pressure and CSF Pressure in Non Neurological Patients. Int. J. Ophthalmol. Vis. Sci. 2018, 3(2), 32-38. doi: 10.11648/j.ijovs.20180302.14

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    AMA Style

    Pragati Garg, Smriti Diwedi, Ritika Mullick. A Correlative Study of Intra Ocular Pressure, Mean Arterial Pressure and CSF Pressure in Non Neurological Patients. Int J Ophthalmol Vis Sci. 2018;3(2):32-38. doi: 10.11648/j.ijovs.20180302.14

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  • @article{10.11648/j.ijovs.20180302.14,
      author = {Pragati Garg and Smriti Diwedi and Ritika Mullick},
      title = {A Correlative Study of Intra Ocular Pressure, Mean Arterial Pressure and CSF Pressure in Non Neurological Patients},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {3},
      number = {2},
      pages = {32-38},
      doi = {10.11648/j.ijovs.20180302.14},
      url = {https://doi.org/10.11648/j.ijovs.20180302.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijovs.20180302.14},
      abstract = {Introduction: Blood pressure is one of the most important and most widely studied factors affecting the IOP. Another important factor that plays an important role in pathogenesis of glaucoma is cerebrospinal fluid pressure. The present study was planned to study the relationship between intraocular pressure, mean arterial pressure and estimated Cerebrospinal fluid pressure in non-neurological patients. Material and Method: The present study was conducted in the Department of Ophthalmology. The study was carried out as a case-control study for 18 months. The patients above 40 years of age irrespective of sex were included in the study after their informed consent. Total of 250 patients were taken out of which 150 were cases with signs of glaucoma and 100 were controls with no signs of glaucoma. Result: 250 subjects enrolled in the study, a total of 150 (60%) were clinically established cases of glaucoma (with IOP >22mmHg) and comprised the case group of study whereas remaining 100 were apparently healthy subjects with no signs and symptoms of glaucoma and had IOP <22 mmHg and comprised the control group of the study. Mean ICP values of subjects with IOP 31-40 mm Hg were significantly higher as compared to those with IOP 23-30 mm Hg and ≤22 mmHg respectively (p=0.002). Mean Arterial Pressure (MAP) showed a significant near mild positive correlation with IOP (r=0.288; p<0.001) and a moderate positive correlation with ICP (r=0.520; p<0.001). However, the correlation between IOP and ICP was weak positive but significant (p=0.010). The relationship between gender and mean MAP and IOP and ICP was evaluated, and the values of all of them were higher in males as compared to females, but the difference was significant only for mean IOP and ICP (p=0.180 and p<0.001 respectively). Conclusion: The findings in present study thus indicate that the relationship between IOP, ICP and MAP is governed by a multitude of factors (in present study these covariates were age, gender and BMI). The present study was unique in the sense that it was probably the first Indian study exploring relationship between IOP, MAP and ICP, and that too in healthy individuals.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - A Correlative Study of Intra Ocular Pressure, Mean Arterial Pressure and CSF Pressure in Non Neurological Patients
    AU  - Pragati Garg
    AU  - Smriti Diwedi
    AU  - Ritika Mullick
    Y1  - 2018/10/15
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijovs.20180302.14
    DO  - 10.11648/j.ijovs.20180302.14
    T2  - International Journal of Ophthalmology & Visual Science
    JF  - International Journal of Ophthalmology & Visual Science
    JO  - International Journal of Ophthalmology & Visual Science
    SP  - 32
    EP  - 38
    PB  - Science Publishing Group
    SN  - 2637-3858
    UR  - https://doi.org/10.11648/j.ijovs.20180302.14
    AB  - Introduction: Blood pressure is one of the most important and most widely studied factors affecting the IOP. Another important factor that plays an important role in pathogenesis of glaucoma is cerebrospinal fluid pressure. The present study was planned to study the relationship between intraocular pressure, mean arterial pressure and estimated Cerebrospinal fluid pressure in non-neurological patients. Material and Method: The present study was conducted in the Department of Ophthalmology. The study was carried out as a case-control study for 18 months. The patients above 40 years of age irrespective of sex were included in the study after their informed consent. Total of 250 patients were taken out of which 150 were cases with signs of glaucoma and 100 were controls with no signs of glaucoma. Result: 250 subjects enrolled in the study, a total of 150 (60%) were clinically established cases of glaucoma (with IOP >22mmHg) and comprised the case group of study whereas remaining 100 were apparently healthy subjects with no signs and symptoms of glaucoma and had IOP <22 mmHg and comprised the control group of the study. Mean ICP values of subjects with IOP 31-40 mm Hg were significantly higher as compared to those with IOP 23-30 mm Hg and ≤22 mmHg respectively (p=0.002). Mean Arterial Pressure (MAP) showed a significant near mild positive correlation with IOP (r=0.288; p<0.001) and a moderate positive correlation with ICP (r=0.520; p<0.001). However, the correlation between IOP and ICP was weak positive but significant (p=0.010). The relationship between gender and mean MAP and IOP and ICP was evaluated, and the values of all of them were higher in males as compared to females, but the difference was significant only for mean IOP and ICP (p=0.180 and p<0.001 respectively). Conclusion: The findings in present study thus indicate that the relationship between IOP, ICP and MAP is governed by a multitude of factors (in present study these covariates were age, gender and BMI). The present study was unique in the sense that it was probably the first Indian study exploring relationship between IOP, MAP and ICP, and that too in healthy individuals.
    VL  - 3
    IS  - 2
    ER  - 

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