American Journal of Laboratory Medicine

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Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation

Received: 23 September 2017    Accepted: 16 October 2017    Published: 14 December 2017
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Abstract

Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.

DOI 10.11648/j.ajlm.20180301.12
Published in American Journal of Laboratory Medicine (Volume 3, Issue 1, January 2018)
Page(s) 6-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antrodia Camphorata, Lipid Peroxidation, Antioxidative Effect, Malondialdehyde

References
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[2] Lee, J. J., Hsu, W. H., Yen, T. L., Chang, N. C., Luo, Y. J., Hsiao, G., & Sheu, J. R. (2011). Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats. J Ethnopharmacol, 134 (3), 824-830.
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[4] Hsiao, G., Shen, M.-Y., Lin, K.-H., Lan, M.-H., Wu, L.-Y., Chou, D.-S., Sheu, J.-R. (2003). Antioxidative and hepatoprotective effects of Antrodia camphorata extract. Journal of agricultural and food chemistry, 51 (11), 3302-3308.
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[6] Hseu, Y.-C., Yang, H.-L., Lai, Y.-C., Lin, J.-G., Chen, G.-W., & Chang, Y.-H. (2004). Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells. Nutrition and Cancer, 48 (2), 189-197.
[7] Song, T.-Y., & Yen, G.-C. (2003). Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. Journal of agricultural and food chemistry, 51 (6), 1571-1577.
[8] Hsu, Y.-L., Kuo, Y.-C., Kuo, P.-L., Ng, L.-T., Kuo, Y.-H., & Lin, C.-C. (2005). Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Cancer letters, 221 (1), 77-89.
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[10] Lee, Y.-M., Chang, C.-Y., Yen, T.-L., Geraldine, P., Lan, C.-C., Sheu, J.-R., & Lee, J.-J. (2014). Extract of Antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence. The Scientific World Journal, 2014.
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[12] Huang, F.-P., Xi, G., Keep, R. F., Hua, Y., Nemoianu, A., & Hoff, J. T. (2002). Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. Journal of neurosurgery, 96 (2), 287-293.
[13] Nazıroğlu, M., Kutluhan, S., Uğuz, A. C., Çelik, Ö., Bal, R., & Butterworth, P. J. (2009). Topiramate and vitamin E modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats. Journal of Membrane Biology, 229 (3), 131-140.
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Author Information
  • Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

  • Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan

  • Department of Nursing, Hung Kuang University, Taichung, Taiwan

  • Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan

  • Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan

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    Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin. (2017). Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. American Journal of Laboratory Medicine, 3(1), 6-10. https://doi.org/10.11648/j.ajlm.20180301.12

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    ACS Style

    Mei-Min Shiu; Bo-Yu Huang; Chien-Chi Liu; Chin-Sheng Liao; Ming-Cheng Lin. Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. Am. J. Lab. Med. 2017, 3(1), 6-10. doi: 10.11648/j.ajlm.20180301.12

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    AMA Style

    Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin. Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. Am J Lab Med. 2017;3(1):6-10. doi: 10.11648/j.ajlm.20180301.12

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  • @article{10.11648/j.ajlm.20180301.12,
      author = {Mei-Min Shiu and Bo-Yu Huang and Chien-Chi Liu and Chin-Sheng Liao and Ming-Cheng Lin},
      title = {Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation},
      journal = {American Journal of Laboratory Medicine},
      volume = {3},
      number = {1},
      pages = {6-10},
      doi = {10.11648/j.ajlm.20180301.12},
      url = {https://doi.org/10.11648/j.ajlm.20180301.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajlm.20180301.12},
      abstract = {Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation
    AU  - Mei-Min Shiu
    AU  - Bo-Yu Huang
    AU  - Chien-Chi Liu
    AU  - Chin-Sheng Liao
    AU  - Ming-Cheng Lin
    Y1  - 2017/12/14
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ajlm.20180301.12
    DO  - 10.11648/j.ajlm.20180301.12
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 6
    EP  - 10
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20180301.12
    AB  - Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.
    VL  - 3
    IS  - 1
    ER  - 

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