This study investigated the prevalence of pulmonary tuberculosis (PTB) associated human immunodeficiency virus/ acquired immunodeficiency syndrome (HIV/AIDs) infection among patients attending Federal Medical Centre Yenagoa, Bayelsa state, Nigeria. Out of the 456 subjects recruited for the study, 88 patients (comprising of male and females) with known cases of PTB was studied for the association of HIV with PTB. Blood and sputum samples were collected following standard procedure. HIV/AIDS was determined following serial all logarithm test viz: Determine, Unigold, Stat pack, while the PTB and rifampicin resistant tuberculosis (RMPR – TB) was analyzed using GeneXpert System. Results showed that 41(9.0%) and 47 (10.3%) was seropositive and seronegative to HIV/AIDS. There was no significant difference (P>0.01) among the serotypes/groups. Also 0.7% of the PTB subjects with HIV were resistant to rifampicin. Therefore, there is the need for surveillance of drug resistance in tuberculosis which could lead strengthening of laboratory networks and enhance its prevention and control.
| Published in | American Journal of Laboratory Medicine (Volume 3, Issue 1) |
| DOI | 10.11648/j.ajlm.20180301.14 |
| Page(s) | 20-24 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
HIV/AIDS, Prevalence, Rifampicin-Resistant Tuberculosis, Tuberculosis
| [1] | Abiodun, I. S., Olanrewaju, A. I., Ladipo, O. A. and Oluberu, A. O. (2015). Incidence of HIV and pulmonary tuberculosis co-infection among patients attending out-patient clinic in a Nigerian hospital. International Journal of Biomedical Research, 6(09): 669-673. |
| [2] | UNAIDS. Global AIDS Update 2017; July 2017. UNAIDS. AIDSinfo website; accessed July 2017, available at: http://aidsinfo.unaids.org/. UNAIDS. Core Epidemiology Slides; June 2017. UNAIDS. Fact Sheet 2017; July 2017. |
| [3] | Kaiser Family Foundation (2017). The Global HIV/AIDS Epidemic. http://files.kff.org/attachment/Fact-Sheet-The-Global-HIV-AIDS-Epidemic. Accessed 26 August 2017. |
| [4] | WHO (2017). Tuberculosis. Fact sheet. http://www.who.int/mediacentre/factsheets/fs104/en/. August 16th, 2017. |
| [5] | Cucunawangsih, Wiwing, V., Widysanto, A., Lugito, N. P. H. (2015). Mycobacterium tuberculosis resistance pattern against first-line drugs in patients from urban area. International Journal of Mycobacteriology, 4: 302–305. |
| [6] | Nasiri, M. J., Rezaei, F., Zamani, S., Darban-Sarokhalil, D., Fooladi, A. A. I., Shojaei, H. and Feizabadi, M. M. (2014). Drug resistance pattern of Mycobacterium tuberculosis isolates from patients of five provinces of Iran. Asian Pacific Journal of Tropical Medicine, No volume: 193-196 |
| [7] | Range, N., Friis, H., Mfaume, S., Magnussen, P., Changalucha, J, Kilale, A., Mugomela, A. and Andersen, A. B. (2012). Anti-tuberculosis drug resistance pattern among pulmonary tuberculosis patients with or without HIV infection in Mwanza, Tanzania. Tanzania Journal of Health Research, 14(4): 1-9. |
| [8] | Bhuju, S., Fonseca, S. DS, Marsico, A. G., Vieira, GDBO., Sobral, L. S., Stehr, M., Singh, M., Saad, M. H. F. (2013). Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene. Infection, Genetics and Evolution 19, 1–6. |
| [9] | Handzel, Z. T. (2013). The Immune Response to Mycobacterium tuberculosis Infection in Humans. https://www.intechopen.com/books/tuberculosis-current-issues-in-diagnosis-and-management/the-immune-response-to-mycobacterium-tuberculosis-infection-in-humans. Accessed 26 August 2017. |
| [10] | Anochie, P. I., Onyeneke, E. C., Onyeneke, C. N., Ogu, A. C. and Onyeozirila, A. C. (2013) Tuberculosis and Human Immunodeficiency Virus Co-Infection in Rural Eastern Nigeria. J Med Diagn Meth 2: 118. doi:10.4172/2168-9784.1000118. |
| [11] | Affusim, C. C., Kesieme, E. and Abah, V. O. (2012). The Pattern of Presentation and Prevalence of Tuberculosis in HIV-Seropositive Patients Seen at Benin City, Nigeria. ISRN Pulmonology, http://dx.doi.org/10.5402/2012/326572. |
| [12] | Oluwaseun, E., Akinduti, P. and Oluwadum, A. (2013). Primary multidrug resistant tuberculosis among HIV seropositive and HIV seronegative patients in Abeokuta, South Western Nigeria. Journal of Research Communication, 1(10): 224-237. |
| [13] | Okorie, O., John, A., Gidado, M., Akang, G., Emperor, U., Rupert, E., Vivian, I, Meribole, E. and Osakwe, P. (2016). The Prevalence of Drug-Resistant Tuberculosis among People Living with HIV (PLHIV) in Abia State. Advances in Infectious Diseases, 06 (2): 10.4236/aid.2016.62009. |
| [14] | Nwobu, G. O., Okodua, M. A. and Tatfeng, Y. M. (2004). Comparative Study Of HIV Associated Pulmonary Tuberculosis In Chest Clinics From Two Regions Of Edo State, Nigeria. Online J Health Allied Scs, 3(3): 1–7. |
| [15] | Onipede, AO, Idigbe O, Ako-Nai AK, Omojola O, Oyelese AO, Aboderin AO, Akinosho, Komolafe AO, Wemambu SN. Sero-prevalence of HIV antibodies in tuberculosis patients in Ile-Ife, Nigeria. East African medical journal, 76 (3): 127-132. |
| [16] | Olaniran, O., Hassan-Olajokun, R. E., Oyovwevotu, M. A. and Agunlejika, R. A (2011). Prevalence of Tuberculosis among HIV/AIDS Patients In Obafemi Awolowo University Teaching Hospital Complex OAUTHC, ILE –IFE. Int J Biol Med Res. 2(4): 874-877. |
| [17] | Idigbe, E. O., Nasidi, A., Anyiwo, C. E., Onubogu, C., Alabi, S., Okoye, R., Ugwu, O. and John, E. K. O (1994). Prevalence of Human Immunodeficiency Virus (HIV) Antibodies in Tuberculosis in Lagos, Nigeria. J Trop. Med. Hyg. 97(2) 91–97. |
| [18] | Daniel, O. J., Salako, A. A., Oluwole, F. A., Alausa, O. K. and Oladapo, O. T. (2004). HIV sero-prevalence among newly diagnosed adult pulmonary tuberculosis patients in Sagamu. Niger J Med., 13(4):393-397. |
| [19] | Iliyasu. Z. and Babashani, M. (2009). Prevalence and predictors of tuberculosis coinfection among HIV-seropositive patients attending the Aminu Kano Teaching Hospital, northern Nigeria. J Epidemiol., 19(2):81-87. |
| [20] | Eledo, B. O., Izah, S. C. and Onuoha, E. C. (2017). Sexually Transmitted Infections among Female Sex Workers in Some Selected Region of Bayelsa State. International STD Research & Reviews, 5(3): 1-6. |
| [21] | Eledo, B. O., Nwoga, M. I., Okamgba, O. C. and Izah, S. C. (2017). Assessment of Some Haemostatic Parameters Among Diabetes Mellitus Patients in Bayelsa State: A Case Study at the Federal Medical Centre, Yenagoa. European Journal of Clinical and Biomedical Sciences. In press. |
| [22] | Seiyaboh, E. I. and Izah, S. C. (2017). Review of Impact of Anthropogenic Activities in Surface Water Resources in the Niger Delta region of Nigeria: A case of Bayelsa state. International Journal of Ecotoxicology and Ecobiology, 2(2): 61–73. |
| [23] | Eledo, B. O., Nwoga, M. I., Okamgba, O. C. and Izah, S. C. (2017). Effect of Exercise on Some Haemostatic Parameters Among Students in a Tertiary Educational Institution in Nigeria. American Journal of Health Research, 5(5): 145 – 148. |
| [24] | Etim, N. G. and Briyai, F. O. (2017). Prevalence of Pulmonary and Rifampicin-resistant tuberculosis among patients attending Federal Medical Centre, Yenagoa, Bayelsa state, Nigeria. International Journal of Healthcare and Medical Sciences. In press. |
| [25] | Ndiok, E. O., Ohimain, E. I. and Izah, S. C. (2016). Incidence of Malaria in Type 2 Diabetic patients and the effect on the liver: a case study of Bayelsa state. Journal of Mosquito Research, 6(15): 1-8. |
| [26] | Van, R., Page-Shipp, L., Sanne, I. and Stevens, W. (2010). Xpert MTB/RIF for Point-of-care diagnosis of TB in high-HIV burden, resource-limited countries: hype or hope? Expert Review Molecular Diagnosis, 10: 937-946. |
| [27] | Okodua, M. A. (2012). Pulmonary tubercuolosis and resistance pattern of first line drugs first line anti- tuberculosis drugs in a city of western Nigeria. International Journal of Basic, Applied and Innovative Research, 1(2): 48-56. |
| [28] | Famuyiwa, M. K. (2015). Association of HIV to Pulmonary Tuberculosis in Chest Clinic of a General Hospital in Lagos, Nigeria. South American Journal of Public Health, 3 (4): 1–7. |
| [29] | Jemikalajah, J. D. and Okogun, G. A (2009). Health point prevalence of human immunodeficiency virus and pulmonary tuberculosis among patients in various parts of Delta State, Nigeria. Saudi Med J., 30 (3): 387–391 |
| [30] | Eyob, G., Guenbrexabher, H., Lemma, E., Wolday, D., Gebeyehu, M., Abate, G., Rigouts, L., Van Soolingen, D., Fontanet, A., Sanders, E. and Dorigo- Zetsma, J. W. (2004). Drugs susceptibility of Mycobacterian tuberculosis in HIV- infected and uninfected Ethiopians and its impact on outcome after 24 months of follow up. International Journal of Tuberculosis and Lung Disease, 8(11):1388-1391. |
| [31] | Chakraborty, N., De, C., Bhattacharyya, S., Mukherjee, S. S., Benerjee, D., Sarkar, R. N. and Guha, S. K. (2010). Drust susceptibility profile of Mycobacterium tuberculosis isolated from HIV infected and uninfected pulmonary tuberculosis patients in Eastern India. Transaction of the Royal Society Tropical Medicine and Hygiene, 104(3):195-201. |
APA Style
Nsikak Godwin Etim, Frankland Oyeins Briyai. (2018). Pulmonary and Rifampicin-Resistant Tuberculosis Associated with Human Immunodeficiency Virus Infection Prevalence in Bayelsa State, Nigeria: A Case of Patients Attending Federal Medical Centre Yenagoa. American Journal of Laboratory Medicine, 3(1), 20-24. https://doi.org/10.11648/j.ajlm.20180301.14
ACS Style
Nsikak Godwin Etim; Frankland Oyeins Briyai. Pulmonary and Rifampicin-Resistant Tuberculosis Associated with Human Immunodeficiency Virus Infection Prevalence in Bayelsa State, Nigeria: A Case of Patients Attending Federal Medical Centre Yenagoa. Am. J. Lab. Med. 2018, 3(1), 20-24. doi: 10.11648/j.ajlm.20180301.14
AMA Style
Nsikak Godwin Etim, Frankland Oyeins Briyai. Pulmonary and Rifampicin-Resistant Tuberculosis Associated with Human Immunodeficiency Virus Infection Prevalence in Bayelsa State, Nigeria: A Case of Patients Attending Federal Medical Centre Yenagoa. Am J Lab Med. 2018;3(1):20-24. doi: 10.11648/j.ajlm.20180301.14
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajlm.20180301.14,
author = {Nsikak Godwin Etim and Frankland Oyeins Briyai},
title = {Pulmonary and Rifampicin-Resistant Tuberculosis Associated with Human Immunodeficiency Virus Infection Prevalence in Bayelsa State, Nigeria: A Case of Patients Attending Federal Medical Centre Yenagoa},
journal = {American Journal of Laboratory Medicine},
volume = {3},
number = {1},
pages = {20-24},
doi = {10.11648/j.ajlm.20180301.14},
url = {https://doi.org/10.11648/j.ajlm.20180301.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20180301.14},
abstract = {This study investigated the prevalence of pulmonary tuberculosis (PTB) associated human immunodeficiency virus/ acquired immunodeficiency syndrome (HIV/AIDs) infection among patients attending Federal Medical Centre Yenagoa, Bayelsa state, Nigeria. Out of the 456 subjects recruited for the study, 88 patients (comprising of male and females) with known cases of PTB was studied for the association of HIV with PTB. Blood and sputum samples were collected following standard procedure. HIV/AIDS was determined following serial all logarithm test viz: Determine, Unigold, Stat pack, while the PTB and rifampicin resistant tuberculosis (RMPR – TB) was analyzed using GeneXpert System. Results showed that 41(9.0%) and 47 (10.3%) was seropositive and seronegative to HIV/AIDS. There was no significant difference (P>0.01) among the serotypes/groups. Also 0.7% of the PTB subjects with HIV were resistant to rifampicin. Therefore, there is the need for surveillance of drug resistance in tuberculosis which could lead strengthening of laboratory networks and enhance its prevention and control.},
year = {2018}
}
TY - JOUR T1 - Pulmonary and Rifampicin-Resistant Tuberculosis Associated with Human Immunodeficiency Virus Infection Prevalence in Bayelsa State, Nigeria: A Case of Patients Attending Federal Medical Centre Yenagoa AU - Nsikak Godwin Etim AU - Frankland Oyeins Briyai Y1 - 2018/01/16 PY - 2018 N1 - https://doi.org/10.11648/j.ajlm.20180301.14 DO - 10.11648/j.ajlm.20180301.14 T2 - American Journal of Laboratory Medicine JF - American Journal of Laboratory Medicine JO - American Journal of Laboratory Medicine SP - 20 EP - 24 PB - Science Publishing Group SN - 2575-386X UR - https://doi.org/10.11648/j.ajlm.20180301.14 AB - This study investigated the prevalence of pulmonary tuberculosis (PTB) associated human immunodeficiency virus/ acquired immunodeficiency syndrome (HIV/AIDs) infection among patients attending Federal Medical Centre Yenagoa, Bayelsa state, Nigeria. Out of the 456 subjects recruited for the study, 88 patients (comprising of male and females) with known cases of PTB was studied for the association of HIV with PTB. Blood and sputum samples were collected following standard procedure. HIV/AIDS was determined following serial all logarithm test viz: Determine, Unigold, Stat pack, while the PTB and rifampicin resistant tuberculosis (RMPR – TB) was analyzed using GeneXpert System. Results showed that 41(9.0%) and 47 (10.3%) was seropositive and seronegative to HIV/AIDS. There was no significant difference (P>0.01) among the serotypes/groups. Also 0.7% of the PTB subjects with HIV were resistant to rifampicin. Therefore, there is the need for surveillance of drug resistance in tuberculosis which could lead strengthening of laboratory networks and enhance its prevention and control. VL - 3 IS - 1 ER -
Information
Email: