Chemical and Biomolecular Engineering
Volume 3, Issue 4, December 2018, Pages: 51-58
Received: Sep. 6, 2018;
Accepted: Sep. 21, 2018;
Published: Oct. 31, 2018
Views 612 Downloads 73
Sharad Medhe, Department of Chemistry, Dayalbagh Educational Institute, Dayalbagh, Agra, India
In Mass spectrometry separation of ions takes place on the basis of there mass to charge ratio. Mass spectroscopy is an advanced and powerful technique for qualitative and quantitative analysis. Detector plays an important role in mass spectrometer for the separated charged ions. Results are displayed as spectra of the relative abundance of detected ions as a function of the mass-to-charge ratio. The detector with desirable properties in mass spectrometer should have high amplification, Fast time response, Low noise, High collection efficiency, Low cost, Narrow distribution of responses, Same response for all masses, Large dynamic range, Long term stability, Long life and can be Mounted outside of the vacuum if possible. Type of mass detectors and there working capacity reviewed in the present article. These mass detectors are a] Electron Multiplier, Faraday cups, Photographic plates, Scintillation counter, channel electron Multipliers, Resistive anode Encoder image Detectors, High mass detection detectors); b] Conversion Dynodes- Helium leak detectors, Advanced detectors; c] Cryogenic Detectors-Multi Pixel Photon counter and d] Other Detectors- TQD Tandem Quadrupole MS Detector, Photonics BI Polar Maldi TOf Detector and Flexar SQ 300 MS Detector. It is also observed that evoluation in mass spectrometry always takes place as per the type and need of analysis.
Mass Spectrometry: Detectors Review, Chemical and Biomolecular Engineering.
Vol. 3, No. 4,
2018, pp. 51-58.
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Stanislav SR, Jonathan VS (2010) A mass spectrometry primer for mass spectrometry imaging. Methods Mol Biol. 656: 21–49.
Khatri N, Gupta A, Taneja R, Bilandi A, Beniwal P (2012) Review on Mass spectrometry detectors. IRJP. 3(10): 33-42.
Ohring M (1995) Engineering materials science; Acedamic Press INC, ISBN-012524995-0, page 568.
Shu XT, Hong WC, Harry VG (2016) Secondary Electron Emission Materials for Transmission Dynodes in Novel Photomultipliers: A Review. Materials. 9(1017): 1-18.
Collins RD (1969) The use of electron multipliers in mass spectrometry. Vacuum. 19 (3): 105-111.
Maithal K, Muralidhar K (2002) Mass Spectrometry an Protein structure. IJBB. 39: 205-216.
Agarwal P, Goyal A (2017) A Review on Analysers for mass spectroscopy. Int J Pharma Bio Sci. 8(4): 139-151.
Potts PJ (1987) Spark Source mass spectroscopy, Chapter 19, Handbook of Silicate rock analysis. ISBN 978-94-015-3990-6.
Bauer HS (2001) Mass spectrometry in the mid-1930’s: were chemists intrigued? J. Am. Soc. Mass Spectrom. 12 (9): 975-988.
Jeeva RJ (2017) Indirect methods of measurements of microbial growth. Power point presentation. https://www.slideshare.net/jeevaraj9/indirect-methods-of-measurement-of.
SPECS application Note, Channel Electron Multipliers, (2006) http://www.specs.de/cms/front_content.php?idart=278.
Brigham RH, Bleiler RJ, McNitt PJ, Reed DA, Fleming RH (1993) Characterization of two resistive anode encoder position sensitive detectors for use in ion microscopy. Review of Scientific Instruments 64: 420.
HEJNA J (2008) Application of channel electron multipliers in an electron detector for low-voltage scanning electron microscopy. J Microsc. 232 (2): 369–378.
Weidmann S, Zenobi R (2014) High-mass MALDI-MS using ion conversion dynode detectors: influence of the conversion voltage on sensitivity and spectral quality. J Am Soc Mass Spectrom. 25(6): 950-954.
INFICON (2007) Leak Detector Catalog, 1-36, [Cited 2012 March 28], Available from https://products.inficon.com/en-us/nav-products/category/productgroup/leak-detectors.
Masataka O, Shiki S, Masahiro U, Go F, Nobuyuki M (2014) Superconducting Tunnel Junction Detectors for Analytical Sciences. IEEE Trans Appl Supercond. 24(4).
Klee JE (2005) Mass Spectrometry of step-growth polymers. Eur. J. Mass Spectrom. 11:591-610.
Zhang G, Gao X, Liu L (2018) Single photon laser ranging with no gating and nanosecond dead time by small pixel Multi-Pixel Photon Counter. Optik-International Journal for Light and Electron Optics. 154: 524-529.
Waters Instrument specification sheet (2015) http://www.waters.com/waters/it_IT/Xevo-TQD-Triple-Quadrupole-Mass-Spectrometry/nav.htm?locale=it_IT&cid=134608730.
Lee J, Chen H, Liu T, Berkman CE, Reilly PTA. (2011) High Resolution Time-of-Flight Mass Analysis of the Entire Range of Intact Singly-Charged Proteins. Anal Chem.15. 83(24): 9406–9412.