Post-transcriptional modifications of nascent mRNA include 5’ capping, splicing and 3’ end polyadenylation, resulting in the emergence of mature mRNA. Recent findings indicate that mRNA splicing inhibitors can be potential anti-cancer candidates. Soy-isoflavone fractions displayed an inhibitory effect of mRNA processing among a number of dietary components. Two major components of the isoflavone fraction, daidzin and genistin did not have an inhibitory activity against mRNA maturation. The aglycone form of them also failed to inhibit mRNA maturation. Instead, compounds with flavone skeleton inhibited the mRNA maturation in the nucleus. Considering that the structural difference between flavone and isoflavone compounds is that B-ring is attached either on the 2’ or 3’ position of C-ring, respectively, anti-mRNA maturation activity may require a defined structural basis. These data indicate that compounds with flavone skeleton specifically alter the mRNA processing step.
| DOI | 10.11648/j.bmb.20170204.13 |
| Published in | Biochemistry and Molecular Biology (Volume 2, Issue 4, July 2017) |
| Page(s) | 46-53 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Flavone, Luciferase Reporter, RNA-FISH
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APA Style
Masashi Kurata, Mari Morimoto, Yuko Kawamura, Intisar Fouad Ali Mursi, Keiko Momma, et al. (2017). Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton. Biochemistry and Molecular Biology, 2(4), 46-53. https://doi.org/10.11648/j.bmb.20170204.13
ACS Style
Masashi Kurata; Mari Morimoto; Yuko Kawamura; Intisar Fouad Ali Mursi; Keiko Momma, et al. Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton. Biochem. Mol. Biol. 2017, 2(4), 46-53. doi: 10.11648/j.bmb.20170204.13
AMA Style
Masashi Kurata, Mari Morimoto, Yuko Kawamura, Intisar Fouad Ali Mursi, Keiko Momma, et al. Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton. Biochem Mol Biol. 2017;2(4):46-53. doi: 10.11648/j.bmb.20170204.13
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Download@article{10.11648/j.bmb.20170204.13,
author = {Masashi Kurata and Mari Morimoto and Yuko Kawamura and Intisar Fouad Ali Mursi and Keiko Momma and Masakazu Takahashi and Yusaku Miyamae and Taiho Kambe and Masaya Nagao and Hiroshi Narita and Yasuyuki Shibuya and Seiji Masuda},
title = {Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton},
journal = {Biochemistry and Molecular Biology},
volume = {2},
number = {4},
pages = {46-53},
doi = {10.11648/j.bmb.20170204.13},
url = {https://doi.org/10.11648/j.bmb.20170204.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20170204.13},
abstract = {Post-transcriptional modifications of nascent mRNA include 5’ capping, splicing and 3’ end polyadenylation, resulting in the emergence of mature mRNA. Recent findings indicate that mRNA splicing inhibitors can be potential anti-cancer candidates. Soy-isoflavone fractions displayed an inhibitory effect of mRNA processing among a number of dietary components. Two major components of the isoflavone fraction, daidzin and genistin did not have an inhibitory activity against mRNA maturation. The aglycone form of them also failed to inhibit mRNA maturation. Instead, compounds with flavone skeleton inhibited the mRNA maturation in the nucleus. Considering that the structural difference between flavone and isoflavone compounds is that B-ring is attached either on the 2’ or 3’ position of C-ring, respectively, anti-mRNA maturation activity may require a defined structural basis. These data indicate that compounds with flavone skeleton specifically alter the mRNA processing step.},
year = {2017}
}
TY - JOUR T1 - Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton AU - Masashi Kurata AU - Mari Morimoto AU - Yuko Kawamura AU - Intisar Fouad Ali Mursi AU - Keiko Momma AU - Masakazu Takahashi AU - Yusaku Miyamae AU - Taiho Kambe AU - Masaya Nagao AU - Hiroshi Narita AU - Yasuyuki Shibuya AU - Seiji Masuda Y1 - 2017/07/31 PY - 2017 N1 - https://doi.org/10.11648/j.bmb.20170204.13 DO - 10.11648/j.bmb.20170204.13 T2 - Biochemistry and Molecular Biology JF - Biochemistry and Molecular Biology JO - Biochemistry and Molecular Biology SP - 46 EP - 53 PB - Science Publishing Group SN - 2575-5048 UR - https://doi.org/10.11648/j.bmb.20170204.13 AB - Post-transcriptional modifications of nascent mRNA include 5’ capping, splicing and 3’ end polyadenylation, resulting in the emergence of mature mRNA. Recent findings indicate that mRNA splicing inhibitors can be potential anti-cancer candidates. Soy-isoflavone fractions displayed an inhibitory effect of mRNA processing among a number of dietary components. Two major components of the isoflavone fraction, daidzin and genistin did not have an inhibitory activity against mRNA maturation. The aglycone form of them also failed to inhibit mRNA maturation. Instead, compounds with flavone skeleton inhibited the mRNA maturation in the nucleus. Considering that the structural difference between flavone and isoflavone compounds is that B-ring is attached either on the 2’ or 3’ position of C-ring, respectively, anti-mRNA maturation activity may require a defined structural basis. These data indicate that compounds with flavone skeleton specifically alter the mRNA processing step. VL - 2 IS - 4 ER -
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