Biochemistry and Molecular Biology
Volume 5, Issue 2, June 2020, Pages: 12-17
Received: Apr. 7, 2020;
Accepted: Apr. 22, 2020;
Published: Apr. 28, 2020
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Ayse Senelmis, Department of Medical Biochemistry, Gazi University, Faculty of Medicine, Ankara, Turkey
Ozge Tugce Pasaoglu, Faculty of Health Science, Gazi University, Ankara, Turkey
Ozant Helvaci, Department of Internal Medicine (Nephrology), Faculty of Medicine, Gazi University, Ankara, Turkey
Ulver Derici, Department of Internal Medicine (Nephrology), Faculty of Medicine, Gazi University, Ankara, Turkey
Hatice Pasaoglu, Department of Medical Biochemistry, Gazi University, Faculty of Medicine, Ankara, Turkey
Aim of the study: Chronic kidney disease is characterized by elevated iFGF-23 level, which is known to regulate phosphate, little is known about the relationship between iFGF-23 and phosphate homeostasis in posttransplant patients, however. We will look at the iFGF-23 level and correlate it with sKlotho, and 1,25 (OH)2 D3 Vitamin in posttransplant patients. Material and methods: This study was conducted using 60 kidney transplant patients. 34 healthy subjects enrolled as a control group. Blood samples were withdrawn for measuring the levels of serum iFGF-23, sKlotho, 1,25 (OH)2 D3 Vitamin, Calcium, Phosphorus, iPTH, 25 (OH) D vitamin. CKD-EPI is used to calculate GFR. Results: iFGF-23 levels were elevated in the posttransplant period compared with healthy subjects. iFGF-23 levels were measured as 263.64±153.08 pg/ml in transplant patients and 155.05±73.40 pg/ml within the control group. sKlotho levels were measured as 2.82±1.76 ng/ml and 3.72±3.59 ng/ml in transplant patients and control groups respectively. 1,25 (OH)2 D3 Vitamin levels were measured as 49.56±13.73 pg/ml and 48.42±12.13 pg/ml in transplant patients and control group respectively. The results of this study revealed a significant correlation between iFGF-23 and sKlotho both in transplant patients and in the control group. Conclusions: Significantly elevated iFGF-23 and iPTH level accompanied by decreased GFR activity suggests a progressive deficiency in phosphate homeostasis.
Ozge Tugce Pasaoglu,
Serum iFGF-23, sKlotho, and 1,25 (OH)2 D3 Vitamin Levels in Kidney Transplant, Biochemistry and Molecular Biology.
Vol. 5, No. 2,
2020, pp. 12-17.
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