The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked

Fawad Akthar; Muhammad Zeeshan; Sajid Ali; Faisal Nouroz; Sara Khan; Fazal Jalil; Uswa Sajid; Hira Ikram; Faheem Anwar

doi:doi:10.11648/j.bmb.20200503.11

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The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked

Fawad Akthar, Muhammad Zeeshan, Sajid Ali, Faisal Nouroz, Sara Khan, Fazal Jalil, Uswa Sajid, Hira Ikram, Faheem Anwar

Published in Biochemistry and Molecular Biology (Volume 5, Issue 3)

Received: 30 September 2019 Accepted: 30 June 2020 Published: 30 October 2020

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Abstract

Rheumatoid Arthritis and Type One Diabetes are devastating clinical conditions characterized by the Autoantibody production against self, affecting up to 5% of population which, ultimately leads to a destruction of cartilage, bones and, insulin; producing Beta cells of Pancreas. As both environmental and genetic factors contribute to these conditions (50-60%). The focus of our review is to enlist that either combined evidence shows the association of Protein Tyrosine Phosphatase Non-receptor type 22 C1858T Polymorphism with these two devastating conditions are not. A minor but most prominent allele of Protein Tyrosine Phosphatase Non-receptor type 22 gene, W620, plays a crucial role in the disease initiation process. The web sources we use for data collection were Google Scholar, PubMed, Online Mendelian Inheritance in Man, and Science Direct. At the same time, the Mesh term of our search was the role of Protein Tyrosine Phosphatase Non-receptor type 22 gene, Single Nucleotide Polymorphism C1858T, 620W, Arg620Trp in Rheumatoid Arthritis and Type One Diabetes. The data set was consist of 210 research articles, which reviewed critically; 73 highly related articles were selected for data extraction to give knowledge to the reader at a glance. Also, taking into account the futuristic perspective for researchers that need further evaluation and will ultimately lead to drug development that will aid enhancement in therapeutics.

Published in	Biochemistry and Molecular Biology (Volume 5, Issue 3)
DOI	10.11648/j.bmb.20200503.11
Page(s)	29-36
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Autoimmune, Devastating, Evidence, Glance, Insulin, Mesh, Monogenic, Prominent

References

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APA Style

Fawad Akthar, Muhammad Zeeshan, Sajid Ali, Faisal Nouroz, Sara Khan, et al. (2020). The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked. Biochemistry and Molecular Biology, 5(3), 29-36. https://doi.org/10.11648/j.bmb.20200503.11

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ACS Style

Fawad Akthar; Muhammad Zeeshan; Sajid Ali; Faisal Nouroz; Sara Khan, et al. The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked. Biochem. Mol. Biol. 2020, 5(3), 29-36. doi: 10.11648/j.bmb.20200503.11

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AMA Style

Fawad Akthar, Muhammad Zeeshan, Sajid Ali, Faisal Nouroz, Sara Khan, et al. The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked. Biochem Mol Biol. 2020;5(3):29-36. doi: 10.11648/j.bmb.20200503.11

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@article{10.11648/j.bmb.20200503.11,
  author = {Fawad Akthar and Muhammad Zeeshan and Sajid Ali and Faisal Nouroz and Sara Khan and Fazal Jalil and Uswa Sajid and Hira Ikram and Faheem Anwar},
  title = {The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked},
  journal = {Biochemistry and Molecular Biology},
  volume = {5},
  number = {3},
  pages = {29-36},
  doi = {10.11648/j.bmb.20200503.11},
  url = {https://doi.org/10.11648/j.bmb.20200503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20200503.11},
  abstract = {Rheumatoid Arthritis and Type One Diabetes are devastating clinical conditions characterized by the Autoantibody production against self, affecting up to 5% of population which, ultimately leads to a destruction of cartilage, bones and, insulin; producing Beta cells of Pancreas. As both environmental and genetic factors contribute to these conditions (50-60%). The focus of our review is to enlist that either combined evidence shows the association of Protein Tyrosine Phosphatase Non-receptor type 22 C1858T Polymorphism with these two devastating conditions are not. A minor but most prominent allele of Protein Tyrosine Phosphatase Non-receptor type 22 gene, W620, plays a crucial role in the disease initiation process. The web sources we use for data collection were Google Scholar, PubMed, Online Mendelian Inheritance in Man, and Science Direct. At the same time, the Mesh term of our search was the role of Protein Tyrosine Phosphatase Non-receptor type 22 gene, Single Nucleotide Polymorphism C1858T, 620W, Arg620Trp in Rheumatoid Arthritis and Type One Diabetes. The data set was consist of 210 research articles, which reviewed critically; 73 highly related articles were selected for data extraction to give knowledge to the reader at a glance. Also, taking into account the futuristic perspective for researchers that need further evaluation and will ultimately lead to drug development that will aid enhancement in therapeutics.},
 year = {2020}
}

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TY  - JOUR
T1  - The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked
AU  - Fawad Akthar
AU  - Muhammad Zeeshan
AU  - Sajid Ali
AU  - Faisal Nouroz
AU  - Sara Khan
AU  - Fazal Jalil
AU  - Uswa Sajid
AU  - Hira Ikram
AU  - Faheem Anwar
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.bmb.20200503.11
DO  - 10.11648/j.bmb.20200503.11
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 29
EP  - 36
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20200503.11
AB  - Rheumatoid Arthritis and Type One Diabetes are devastating clinical conditions characterized by the Autoantibody production against self, affecting up to 5% of population which, ultimately leads to a destruction of cartilage, bones and, insulin; producing Beta cells of Pancreas. As both environmental and genetic factors contribute to these conditions (50-60%). The focus of our review is to enlist that either combined evidence shows the association of Protein Tyrosine Phosphatase Non-receptor type 22 C1858T Polymorphism with these two devastating conditions are not. A minor but most prominent allele of Protein Tyrosine Phosphatase Non-receptor type 22 gene, W620, plays a crucial role in the disease initiation process. The web sources we use for data collection were Google Scholar, PubMed, Online Mendelian Inheritance in Man, and Science Direct. At the same time, the Mesh term of our search was the role of Protein Tyrosine Phosphatase Non-receptor type 22 gene, Single Nucleotide Polymorphism C1858T, 620W, Arg620Trp in Rheumatoid Arthritis and Type One Diabetes. The data set was consist of 210 research articles, which reviewed critically; 73 highly related articles were selected for data extraction to give knowledge to the reader at a glance. Also, taking into account the futuristic perspective for researchers that need further evaluation and will ultimately lead to drug development that will aid enhancement in therapeutics.
VL  - 5
IS  - 3
ER  -

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Author Information

Fawad Akthar

Department of Biotechnology, Islamic International University, Islamabad, Pakistan
Muhammad Zeeshan

Department of Bioinformatics, Hazara University, Manshera Kpk, Pakistan
Sajid Ali

Department of Biotechnology, Abdul Wali Khan University, Mardan Kpk, Pakistan
Faisal Nouroz

Department of Bioinformatics, Hazara University, Manshera Kpk, Pakistan
Sara Khan

Department of Bioinformatics, Hazara University, Manshera Kpk, Pakistan
Fazal Jalil

Department of Biotechnology, Abdul Wali Khan University, Mardan Kpk, Pakistan
Uswa Sajid

Department of Zoology, Hazara University, Mansehra Kpk, Pakistan
Hira Ikram

Department of Biochemistry, Abdul Wali Khan University, Mardan Kpk, Pakistan
Faheem Anwar

Department of Genetics, Hazara University, Mansehra Kpk, Pakistan

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APA Style

Fawad Akthar, Muhammad Zeeshan, Sajid Ali, Faisal Nouroz, Sara Khan, et al. (2020). The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked. Biochemistry and Molecular Biology, 5(3), 29-36. https://doi.org/10.11648/j.bmb.20200503.11

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ACS Style

Fawad Akthar; Muhammad Zeeshan; Sajid Ali; Faisal Nouroz; Sara Khan, et al. The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked. Biochem. Mol. Biol. 2020, 5(3), 29-36. doi: 10.11648/j.bmb.20200503.11

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AMA Style

Fawad Akthar, Muhammad Zeeshan, Sajid Ali, Faisal Nouroz, Sara Khan, et al. The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked. Biochem Mol Biol. 2020;5(3):29-36. doi: 10.11648/j.bmb.20200503.11

Copy | Download

@article{10.11648/j.bmb.20200503.11,
  author = {Fawad Akthar and Muhammad Zeeshan and Sajid Ali and Faisal Nouroz and Sara Khan and Fazal Jalil and Uswa Sajid and Hira Ikram and Faheem Anwar},
  title = {The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked},
  journal = {Biochemistry and Molecular Biology},
  volume = {5},
  number = {3},
  pages = {29-36},
  doi = {10.11648/j.bmb.20200503.11},
  url = {https://doi.org/10.11648/j.bmb.20200503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20200503.11},
  abstract = {Rheumatoid Arthritis and Type One Diabetes are devastating clinical conditions characterized by the Autoantibody production against self, affecting up to 5% of population which, ultimately leads to a destruction of cartilage, bones and, insulin; producing Beta cells of Pancreas. As both environmental and genetic factors contribute to these conditions (50-60%). The focus of our review is to enlist that either combined evidence shows the association of Protein Tyrosine Phosphatase Non-receptor type 22 C1858T Polymorphism with these two devastating conditions are not. A minor but most prominent allele of Protein Tyrosine Phosphatase Non-receptor type 22 gene, W620, plays a crucial role in the disease initiation process. The web sources we use for data collection were Google Scholar, PubMed, Online Mendelian Inheritance in Man, and Science Direct. At the same time, the Mesh term of our search was the role of Protein Tyrosine Phosphatase Non-receptor type 22 gene, Single Nucleotide Polymorphism C1858T, 620W, Arg620Trp in Rheumatoid Arthritis and Type One Diabetes. The data set was consist of 210 research articles, which reviewed critically; 73 highly related articles were selected for data extraction to give knowledge to the reader at a glance. Also, taking into account the futuristic perspective for researchers that need further evaluation and will ultimately lead to drug development that will aid enhancement in therapeutics.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked
AU  - Fawad Akthar
AU  - Muhammad Zeeshan
AU  - Sajid Ali
AU  - Faisal Nouroz
AU  - Sara Khan
AU  - Fazal Jalil
AU  - Uswa Sajid
AU  - Hira Ikram
AU  - Faheem Anwar
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.bmb.20200503.11
DO  - 10.11648/j.bmb.20200503.11
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 29
EP  - 36
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20200503.11
AB  - Rheumatoid Arthritis and Type One Diabetes are devastating clinical conditions characterized by the Autoantibody production against self, affecting up to 5% of population which, ultimately leads to a destruction of cartilage, bones and, insulin; producing Beta cells of Pancreas. As both environmental and genetic factors contribute to these conditions (50-60%). The focus of our review is to enlist that either combined evidence shows the association of Protein Tyrosine Phosphatase Non-receptor type 22 C1858T Polymorphism with these two devastating conditions are not. A minor but most prominent allele of Protein Tyrosine Phosphatase Non-receptor type 22 gene, W620, plays a crucial role in the disease initiation process. The web sources we use for data collection were Google Scholar, PubMed, Online Mendelian Inheritance in Man, and Science Direct. At the same time, the Mesh term of our search was the role of Protein Tyrosine Phosphatase Non-receptor type 22 gene, Single Nucleotide Polymorphism C1858T, 620W, Arg620Trp in Rheumatoid Arthritis and Type One Diabetes. The data set was consist of 210 research articles, which reviewed critically; 73 highly related articles were selected for data extraction to give knowledge to the reader at a glance. Also, taking into account the futuristic perspective for researchers that need further evaluation and will ultimately lead to drug development that will aid enhancement in therapeutics.
VL  - 5
IS  - 3
ER  -

Copy | Download