Zinc Oxide Nanoparticles: The Hidden Danger
International Journal of Biochemistry, Biophysics & Molecular Biology
Volume 2, Issue 1, February 2017, Pages: 1-9
Received: Oct. 19, 2016; Accepted: Nov. 12, 2016; Published: Feb. 22, 2017
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Mona A. El Shemy, Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt
Naglaa Ibrahim Azab, Department of Medical Biochemistry, Faculty of Medicine, Benha University, Benha, Egypt
Rabab Fawzy Salim, Department of Medical Biochemistry, Faculty of Medicine, Benha University, Benha, Egypt
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Zinc oxide nanoparticles (ZnO-NPs) are used in many industries and medications, increasing the exposure to ZnO-NPs that may have harmful side effects. So, we studied the hepatotoxic effect of ZnO-NPs and explored the role of vitamin E in the reduction of their toxic effects. Forty male albino rats, divided into four groups (10 rats per group) were included in the study; control group, ZnO-NPs intoxicated group, vitamin E control group and vitamin E protected ZnO-NPs intoxicated group. ZnO-NPs were given in a dose of 400 mg / kg body weight for seven days. Vitamin E was given in a dose of 100 mg / kg body weight for four weeks. Our results showed that ZnO-NPs induced liver damage indicated by significant increase of serum ALT and AST and significant decrease of serum albumin and total protein levels. Moreover, ZnO-NPs induced oxidative stress in the liver suggested by significant elevation of malondialdehyde level and significant reduction of reduced glutathione level, glutathione peroxidase activity and glutathione peroxidase-1 expression in liver homogenate. Furthermore, ZnO-NPs caused significant increase in the serum pro-inflammatory biomarker, tumor necrosis factor alpha (TNF- α). On the other hand, vitamin E alleviated the liver damage, oxidative stress and the elevated serum TNF- α induced by ZnO-NPs.
Zinc Oxide Nanoparticles (ZnO-NPs), Vitamin E, Liver, Oxidative Stress, Tumor Necrosis Factor Alpha (TNF- α)
To cite this article
Mona A. El Shemy, Naglaa Ibrahim Azab, Rabab Fawzy Salim, Zinc Oxide Nanoparticles: The Hidden Danger, International Journal of Biochemistry, Biophysics & Molecular Biology. Vol. 2, No. 1, 2017, pp. 1-9. doi: 10.11648/j.ijbbmb.20170201.11
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