International Journal of Biochemistry, Biophysics & Molecular Biology

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Zinc Oxide Nanoparticles: The Hidden Danger

Received: 19 October 2016    Accepted: 12 November 2016    Published: 22 February 2017
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Abstract

Zinc oxide nanoparticles (ZnO-NPs) are used in many industries and medications, increasing the exposure to ZnO-NPs that may have harmful side effects. So, we studied the hepatotoxic effect of ZnO-NPs and explored the role of vitamin E in the reduction of their toxic effects. Forty male albino rats, divided into four groups (10 rats per group) were included in the study; control group, ZnO-NPs intoxicated group, vitamin E control group and vitamin E protected ZnO-NPs intoxicated group. ZnO-NPs were given in a dose of 400 mg / kg body weight for seven days. Vitamin E was given in a dose of 100 mg / kg body weight for four weeks. Our results showed that ZnO-NPs induced liver damage indicated by significant increase of serum ALT and AST and significant decrease of serum albumin and total protein levels. Moreover, ZnO-NPs induced oxidative stress in the liver suggested by significant elevation of malondialdehyde level and significant reduction of reduced glutathione level, glutathione peroxidase activity and glutathione peroxidase-1 expression in liver homogenate. Furthermore, ZnO-NPs caused significant increase in the serum pro-inflammatory biomarker, tumor necrosis factor alpha (TNF- α). On the other hand, vitamin E alleviated the liver damage, oxidative stress and the elevated serum TNF- α induced by ZnO-NPs.

DOI 10.11648/j.ijbbmb.20170201.11
Published in International Journal of Biochemistry, Biophysics & Molecular Biology (Volume 2, Issue 1, February 2017)
Page(s) 1-9
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Zinc Oxide Nanoparticles (ZnO-NPs), Vitamin E, Liver, Oxidative Stress, Tumor Necrosis Factor Alpha (TNF- α)

References
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Author Information
  • Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt

  • Department of Medical Biochemistry, Faculty of Medicine, Benha University, Benha, Egypt

  • Department of Medical Biochemistry, Faculty of Medicine, Benha University, Benha, Egypt

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    Mona A. El Shemy, Naglaa Ibrahim Azab, Rabab Fawzy Salim. (2017). Zinc Oxide Nanoparticles: The Hidden Danger. International Journal of Biochemistry, Biophysics & Molecular Biology, 2(1), 1-9. https://doi.org/10.11648/j.ijbbmb.20170201.11

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    Mona A. El Shemy; Naglaa Ibrahim Azab; Rabab Fawzy Salim. Zinc Oxide Nanoparticles: The Hidden Danger. Int. J. Biochem. Biophys. Mol. Biol. 2017, 2(1), 1-9. doi: 10.11648/j.ijbbmb.20170201.11

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    AMA Style

    Mona A. El Shemy, Naglaa Ibrahim Azab, Rabab Fawzy Salim. Zinc Oxide Nanoparticles: The Hidden Danger. Int J Biochem Biophys Mol Biol. 2017;2(1):1-9. doi: 10.11648/j.ijbbmb.20170201.11

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  • @article{10.11648/j.ijbbmb.20170201.11,
      author = {Mona A. El Shemy and Naglaa Ibrahim Azab and Rabab Fawzy Salim},
      title = {Zinc Oxide Nanoparticles: The Hidden Danger},
      journal = {International Journal of Biochemistry, Biophysics & Molecular Biology},
      volume = {2},
      number = {1},
      pages = {1-9},
      doi = {10.11648/j.ijbbmb.20170201.11},
      url = {https://doi.org/10.11648/j.ijbbmb.20170201.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijbbmb.20170201.11},
      abstract = {Zinc oxide nanoparticles (ZnO-NPs) are used in many industries and medications, increasing the exposure to ZnO-NPs that may have harmful side effects. So, we studied the hepatotoxic effect of ZnO-NPs and explored the role of vitamin E in the reduction of their toxic effects. Forty male albino rats, divided into four groups (10 rats per group) were included in the study; control group, ZnO-NPs intoxicated group, vitamin E control group and vitamin E protected ZnO-NPs intoxicated group. ZnO-NPs were given in a dose of 400 mg / kg body weight for seven days. Vitamin E was given in a dose of 100 mg / kg body weight for four weeks. Our results showed that ZnO-NPs induced liver damage indicated by significant increase of serum ALT and AST and significant decrease of serum albumin and total protein levels. Moreover, ZnO-NPs induced oxidative stress in the liver suggested by significant elevation of malondialdehyde level and significant reduction of reduced glutathione level, glutathione peroxidase activity and glutathione peroxidase-1 expression in liver homogenate. Furthermore, ZnO-NPs caused significant increase in the serum pro-inflammatory biomarker, tumor necrosis factor alpha (TNF- α). On the other hand, vitamin E alleviated the liver damage, oxidative stress and the elevated serum TNF- α induced by ZnO-NPs.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Zinc Oxide Nanoparticles: The Hidden Danger
    AU  - Mona A. El Shemy
    AU  - Naglaa Ibrahim Azab
    AU  - Rabab Fawzy Salim
    Y1  - 2017/02/22
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ijbbmb.20170201.11
    DO  - 10.11648/j.ijbbmb.20170201.11
    T2  - International Journal of Biochemistry, Biophysics & Molecular Biology
    JF  - International Journal of Biochemistry, Biophysics & Molecular Biology
    JO  - International Journal of Biochemistry, Biophysics & Molecular Biology
    SP  - 1
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2575-5862
    UR  - https://doi.org/10.11648/j.ijbbmb.20170201.11
    AB  - Zinc oxide nanoparticles (ZnO-NPs) are used in many industries and medications, increasing the exposure to ZnO-NPs that may have harmful side effects. So, we studied the hepatotoxic effect of ZnO-NPs and explored the role of vitamin E in the reduction of their toxic effects. Forty male albino rats, divided into four groups (10 rats per group) were included in the study; control group, ZnO-NPs intoxicated group, vitamin E control group and vitamin E protected ZnO-NPs intoxicated group. ZnO-NPs were given in a dose of 400 mg / kg body weight for seven days. Vitamin E was given in a dose of 100 mg / kg body weight for four weeks. Our results showed that ZnO-NPs induced liver damage indicated by significant increase of serum ALT and AST and significant decrease of serum albumin and total protein levels. Moreover, ZnO-NPs induced oxidative stress in the liver suggested by significant elevation of malondialdehyde level and significant reduction of reduced glutathione level, glutathione peroxidase activity and glutathione peroxidase-1 expression in liver homogenate. Furthermore, ZnO-NPs caused significant increase in the serum pro-inflammatory biomarker, tumor necrosis factor alpha (TNF- α). On the other hand, vitamin E alleviated the liver damage, oxidative stress and the elevated serum TNF- α induced by ZnO-NPs.
    VL  - 2
    IS  - 1
    ER  - 

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