Factors Associated with Adherence of Highly Active Antiretroviral Therapy among Adult HIV/AIDS Patients in Mekelle Hospital Northern Ethiopia
Science Journal of Public Health
Volume 2, Issue 4, July 2014, Pages: 367-372
Received: Jul. 7, 2014;
Accepted: Jul. 23, 2014;
Published: Jul. 30, 2014
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Kiday Hailasillassie, School of Public Health, Reproductive Health and Nutrition team, Mekelle University, Mekelle, Ethiopia
Belachew Etana, School of Public Health, Health service Management Team, Mekelle University, Mekelle, Ethiopia
Mussie Alemayehu, School of Public Health, Reproductive Health and Nutrition team, Mekelle University, Mekelle, Ethiopia
Girmatsion Fisseha, School of Public Health, Reproductive Health and Nutrition team, Mekelle University, Mekelle, Ethiopia
Background: Drug adherence is the most important in progression of disease among HIV positive individuals under antiretroviral treatment. Besides, it is the main factor for survival. So the objective was to assess factors association with adherence of ART among adult people living with HIV/AIDS. Methods: A cross-sectional study was carried out among adult PLWHA attending HAART at Mekelle Hospital during June 2012. A total of 422 participants were recruited by systemic random sampling by daily patient load of ART clinic. Standard questionnaire was used to collect data after we pre-tested. The data was entered in to a computer by Epi-data 3.1 and analyzed using SPSS 20. Bivariate and multiple logistic regression analysis were done to determine factors associated with drug adherence. Odds ratio with their 95% confidence intervals and p-values less than 0.05 was considered as statistically significant association. Result: a total 403 people living on with HIV/AIDS were responded to the study with 95% response rate. The mean age of participants was 38.44 years and on average they were on ART for 3 years and 5 months on ART. A total adherence level was 63.4% and HIV positive who had their own income (2.1 95% CI: 1.2, 3.9), urban residence (2.3 95% CI: 1.2, 4.5) and being diagnosed in Mekelle Hospital (1.8 95% CI: 1.2, 2.9) were independently predicts HAART adherence. Conclusion: Drug adherence level was very low in Mekelle hospital and patients place of residence, economic status and being diagnosed in Mekelle hospital were independent predictors for adherence. So, awareness creation for rural residence and income generation method should be created to increase adherence level.
Factors Associated with Adherence of Highly Active Antiretroviral Therapy among Adult HIV/AIDS Patients in Mekelle Hospital Northern Ethiopia, Science Journal of Public Health.
Vol. 2, No. 4,
2014, pp. 367-372.
UNAIDS. Global report: UNAIDS report on the global AIDS epidemic2012.
Federal Democratic Repulic of Ethiopia. Country Progress Report on HIV/AIDS Response. Addis Ababa 2012.
L. Sherr, F.C. Lampe, C. Clucas, M. Johnson, M. Fisher, H. Leake Date, et al. Self-reported non-adherence to ART and virological outcome in a multiclinic UK study. Care: Psychological and Socio-medical Aspects of AIDS/HIV2010;22(8):939-45.
World health organization. From access to adherence: the challenges of antiretroviral treatment. Anita H, Sheila D, Trudie G, Catherine H, Henry I, Joyce K, et al., editors. Geneva WHO; 2006
Abaasa AM, Todd J, Ekoru K, Kalyango JN, Levin J, Odeke E, et al. Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care programme: the experience of The AIDS Support Organization (TASO), Kampala, Uganda. BMC Health Services Research 2008; 8(241):doi:10.1186/472-6963-8-241.
Markos E, Worku A, Davey G. Adherence to ART in PLWHA at Yirgalem Hospital, South Ethiopia. EthiopJHealth Dev2008;22 (2):174-9.
Reda AA, Biadgilign S. Determinants of Adherence to Antiretroviral Therapy among HIV-Infected Patients in Africa. AIDS Research and Treatment. [Review ]. 2012;Article ID 574656(doi:10.1155/2012/574656).
Tessema B, Biadglegne F, Mulu A, Getachew A, Emmrich F , Ulrich S. Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study. AIDS Research and Therapy 2010; 7(2).
Tiyou A, Belachew T, Alemseged F, Biadgilign S. Predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in resourcelimited setting of southwest ethiopia. AIDS Research and Therapy 2010; 7(39).
Wakibi S, Ng’ang Z, Mbugua G. Factors associated with non-adherence to highly active antiretroviral therapy in Nairobi, Kenya. AIDS Research and Therapy 2011;8(43):http://www.aidsrestherapy.com/content/8/1/43
Afolabi M, Ijadunola K, Fatusi A, Olasode O. Determinants of adherenceto antiretroviral drugsamong people living withHIV/AIDS in the Ife-Ijesazone of Osun state, Nigeria. Afr J Prm Health Care Fam Med 2009;1(1):Art. #6, pages. DOI: 10.4102/phcfm.v1i1.6.
Silva Mcf, Ximenes Raa, Miranda Filho Db, Arraes Lwms, Mendes M, Melo Acs, et al. Risk-factors for non-adherence to antiretroviral therapy. Rev Inst Med trop S Paulo 2009;15(3):135-9.
Peltzer K, Friend-du Preez N, Ramlagan S, Anderson J. Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa. BMC Public Health 2010; 10(111):http://www.biomedcentral.com/1471-2458/10/111
Wasti S, Simkhada P, Randall J, Freeman J, van Teijlingen E. Factors Influencing Adherence to Antiretroviral Treatment in Nepal: A Mixed-Methods Study. PLoS ONE 2012;7(5):e35547. doi:10.1371/journal.pone.0035547.