The Effect of Khat (Catha edulis) Chewing on Blood Pressure among Male Adult Chewers, Bahir Dar, North West Ethiopia
Science Journal of Public Health
Volume 2, Issue 5, September 2014, Pages: 461-468
Received: Aug. 18, 2014;
Accepted: Sep. 1, 2014;
Published: Sep. 20, 2014
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Bizuayehu Walle Birhane, Medical physiology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia
Muluken Walle Birhane, Medical physiology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia
Khat is found in the evergreen tree or large shrub, consists of whole fresh leaves and buds of a plant known as Catha edulis. Bahir Dar is a city that three percent of Ethiopia’s total production of khat is originated from. There is no community based study that has been done in Bahir Dar city to determine effects of khat chewing behaviours on risk to elevated blood pressure. Therefore, this study aimed to assess effect of khat chewing on systolic and diastolic blood pressure. A community based cross-sectional study was conducted from January to September 2013among chewers of Bahir Dar city for determine effect of khat chewing on systolic and diastolic blood pressure. A structured questioner and medical measuring equipments were used to collect socio-demographic data, khat chewing behaviours and levels of physiological parameters. A total of 422 male khat chewers were included in study, 422 respond to the questioners, giving a response rate of 100%. The multivariate analysis result shown that the figure of having elevated systolic blood pressure among male chewers who chewed frequently was fourteen times more compared to who chewed less frequently (AOR:14.95,95%CI:5.49-40.66). The analysis result also revealed that those who spent more than 6 hours in a khat session were 7.25 times more likely to have elevated systolic blood pressure compared to those who spent less than 6 hours, (AOR :7.25; 95%CI: 4.03-13.05). It was also found that those who spent more than 6 hours in a khat session were almost 9 times more likely to have elevated diastolic blood pressure compared to those who spent less than 6 hours (AOR:8.99,95%CI:4.85-16.66). As for amount of khat chewed in the last 12 months, the risk of elevated systolic blood pressure was more than 5.26 times more likely among male chewers who reported increase amount of khat chewing compared to those who reported decrease the amount in the last 12 months, (AOR:5.26:95% CI: 2.76-10.15). Similarly, the risk of elevated diastolic blood pressure was more than 7 times more likely among male chewers who reported increase amount of khat chewing compared to those who reported decrease amount of khat chewing in last 12 months (AOR:7.25,95%CI:3.66-14.38). According to the study result explained above, it is possible to conclude that khat chewing behaviours have significant effect on blood pressure.
Bizuayehu Walle Birhane,
Muluken Walle Birhane,
The Effect of Khat (Catha edulis) Chewing on Blood Pressure among Male Adult Chewers, Bahir Dar, North West Ethiopia, Science Journal of Public Health.
Vol. 2, No. 5,
2014, pp. 461-468.
Al-Hebshi N, Skaug N: Khat (Catha edulis) - an updated review. Addiction Biology 2005, 10:299-307
Sawair F. A., Al - Mutwakel A. Al - Eryani K. , Al - Surhy A. , Mar uyama S. , Cheng J . , Al - Sharabi A. , Saku T. High relative frequency of oral squamous cell carcinoma in Yemen: Qat and tobacco chewing as its aetiological back ground. International Journal of Environmental Health Research. 2 007, 1 7(3): 185 – 1 95.
Kebede Y: Cigarette smoking and khat chewing among university instructors in Ethiopia. East Afr. Med. J. (2002) 79:274-278.
Ayana Am, Sherief Ht, Tekli Y: Effect of khat (Catha edulis Forsk) on blood pressure and heart rate, a community based study. Ethiop. J. Health Dev. (2002) 16:325-334.
Central Statistics Authority. 1993, Addis Ababa, Ethiopia, 1998.
Peter D. Khat: its history, botany, chemistry and toxicology. Parmac. Journal CLXD: 1952, 36:39
Szendrei K: The chemistry of khat. Bull. Narc. (1980) 32:5-35.
Kalix P: Cathinone, a natural amphetamine. Pharmacol. Toxicol. (1992) 70:77-86.
Schorno X, Steinegger E: CNS-active phenylpropylamines of Catha edulis Forsk (Celastraceae) of Kenyan origin. Experintia (1979) 35:572-574.
Brenneisen R, Geisshusler S: Psychotropic drugs. Part III. Analytical and chemical aspects of Catha edulis Forsk Pharm. Acta Helv. (1985) 60:290-301.
Schechter MD: Dopaminergic nature of acute cathine tolerance. Pharmacol. Biochem. Behav. (1990) 36:817-820.
Lugman W, Danowski T: The use of khat in Yemen: social and medical observations. Ann. Intern. Med.(1976) 85:245-249.
Patel NB: Mechanism of action of Cathinone: the active ingredient of Khat (Catha edulis). East Afr Med J 2000, 77:329-332.
Kebede D, Alem A, Mitikie G, Enquselassie F, Berhane F, Abebe Y, Ayele R, Lemma W, Assefa T, Gebremichael T: Khat and alcohol use and risky sex behavior among in-school and out-of-school youth in Ethiopia. BMC Public Health 2005, 5:109-114.
National Drug Intelligence Center, US Department of Justice: Drugs enforcement administration; Drugs and chemicals of concern "Khat". 2006 [http://www.justice.gov/dea/concern/khat.html]..
Nencini P, Ahmed AM: Khat consumption: a pharmacological review. Drug Alcohol Depend. (1989) 23:19-29.
Kalix P: Pharmacological properties of the stimulant khat. Pharmacol. Ther. (1990) 48:397-416.
Nencini P, Abdllah A, Amiconi G, Elmi A: Tolerance develops to sympathetic effects of khat in humans. Pharmacology (1984) 28:150-154.
Hassan Na, Gunaid Aa, Abdo Rabbo AA ET AL: The effect of khat chewing on blood pressure and heart rate in healthy volunteers. Trop. Doct. (2000) 30:107-108.
Kohli J, Goldberg L: Cardiovascular effect of (-)-cathinone in the anaesthetized dog: Comparison with (+)-amphetamine. J. Pharm. Pharmacol. (1982) 34:338-340.
Kalix P: Effect of the alkaloid cathinone on the release of radioactivity from rabbit atria prelabelled with 3H-norepinepherine. Life Sci. (1983) 32:801-807.
Al-Motarreb A, Baker K, Broadley KJ: Khat: Pharmacological and medical aspects and its social use in Yemen. Phytotherapy Res. (2002) 16:403-413.
Heymann TD, Bhupulan A, Zuriekat NEK, Bomanji J, Drinkwater C, Giles P. Murray-Lyon IM. Khat chewing delays gastric emptying of a semi-solid meal. Aliment Pharmacol Ther.1995; 9: 81–83.
Gunaid AA, El Khally FMY, Hassan NAGM, Murray-Lyon IM. Chewing qat leaves slows the whole gut transit time. Saudi Med Journal. 1999; 20: 444–447.
Kennedy JG, Teague J, Fairbanks L: Qat use in North Yemen and the problem of addiction: a study in medical anthropology. Cult. Med. Psychiatry (1980) 4:311-344.
Pantelis C, Hindler CG, Taylor JC: Use and abuse of khat (Catha edulis): a review of the distribution, pharmacology, side effects and a description of psychosis attributed to khat chewing. Psychol. Med. (1989) 19:657-668.
National Drug Intelligence Center: Khat (Catha edulis): Intelligence Bulletin 2003 [http://www.justice.gov/ndic/pubs3/3920/index.htm]. No. 2003.L0424-002
Alem A, Kebede D, Kullagern G: The prevalence and socio-demographic correlates of Khat chewing in Butajira, Ethiopia. Acta Psychiatrica Scand 1999, 397:84-91.
Mossie A, Mekonnen Z: Khat (Catha edulis Forsk) chewing, sociodemographic description and its effect on academic performance, Jimma University students. Ethiop Med J 2004, 42:125-143.
Ibrahim MM: Future of research in hypertension in developing countries. Eastern Mediterranean Health Journal 1996, 2:202-205.
Dechassa, L. Khat (Catha edulis): Botany, Distribution, Cultivation, Usage and Economics in Ethiopia. UN Emergencies Unit for Ethiopia, Addis Ababa, 2001.
Yigzaw Kebede, Tefera Abula, Belete Ayele, Amsalu Feleke, Getu Degu, Abera Kifle, Zeleke Alebachew, En dris Mekonnen, and Belay Tessema. Substance Abuse For the Ethiopian Health Center Team: Gonder University. 2005: 7 - 19
Belew M, Kebede D, Kassaye M, Enquoselassie F. The magnitude of khat use and its association with health, nutrition and socio-economic status. Ethiop Med Journal, 2000, 38(1): 11-26.
Numan N. Exploration of adverse psychological symptoms in Yemeni khat users by the Symptoms Checklist-90 (SCL-90). Addiction. 2004, 99(1): 61-5.
World Bank. Yemen towards Qat demand reduction. 2007, 39738-YE.
Ayana AM, Mekonen Z (2004). Khat (Catha edulis Forsk) chewing, socio-demographic description and its effect on academic performance, Jimma University students. Ethiop Med J. 2002. 42(2): 125-36.
Belew M, Kebede D, Kassaye M, Enquoselassie F (2000). The magnitude of khat use and its association with health, nutrition and socio-economic status. Ethiop Med J 38(1): 11-26.
Ayana A, Sharif H, Tekli Y (2002). Effects of khat (Catha edulis forsk) on blood pressure and heart rate, a community based study. Ethiopian Journal Development 16(3): 325-334.
Kassim S(2010). An Exploration of the Association between Khat Chewing and Health Outcomes in UK-resident Male Yemeni Khat Chewers,22-62
Fekade A, Challi J, Tadess M. Khat chewing among Agaro secondary school students. Ethiop Medic J. 1994;32:161- 166.
Kalman S. Recent progress in khat chemistry: in chemical and pharmacological aspect of khat; international symposium of khat. 1983;13- 28.
Al-Motarreb AL, Al-Kebsi M, Al-Adhi B, Broadley KJ. Khat chewing and acute myocardial infarction. Heart. 2002; 87: 279–280.
Wilder P, Mathys K, Brenneisen R, Kalix P, Fisch HU. Pharmacodynamics and pharmacokinetics of khat: a controlled study. Clin Pharmacol Ther. 1994; 59:556- 562.