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Use of Isoniazid Preventive Therapy on HIV/AIDS Patient in a Tertiary Health Facility South Eastern Nigeria

Received: 2 February 2015    Accepted: 19 February 2015    Published: 12 March 2015
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Abstract

Introduction: The Human Immuno-deficiency virus / Acquired immune-deficiency syndrome (HIV/AIDs) is a very serious disease and pandemic. There have been series of interventions to combat the disease and these include, Prevention of mother to child transmission, HIV counseling and testing, treatment of HIV/AIDs with antiretroviral drugs and the three I’s which include Intensive case search, Infection control and Isoniazid preventive therapy (IPT). There appears to be paucity of information on the IPT in our environment and it is therefore necessary to find out how the IPT has been implemented in this part of the world. Objective: To determine the number of Cases of HIV placed on IPT. Methodology: This is a cross sectional study in which the HIV patients who were placed on the IPT were identified and followed up. The situational analysis was carried out to identify those already placed on IPT. The next stage was training of the doctors on IPT and informing them on the importance of IPT in the management of HIV patients. Data tools were provided. A focal person was selected to fill these data tools to be able to get accurate number of HIV patients on IPT. Data was analyzed with Microsoft Excel and Epi. Info. Results: The total number of new cases of HIV seen from July to September 2013 was 218, of which (30% N=65) was started on IPT. Of the 65 that started the IPT only (63%, N=41) continued the second month. The number of suspected TB were (2.3% N=5). The number of cases of TB- Co infection (0.4% N=1). Conclusion: The IPT is being utilized in this health facility for prevention of TB in HIV/AIDs although at a low rate, however the creation of more awareness among Doctors and Patients and proper documentation, will further improve the uptake of IPT.

Published in Science Journal of Public Health (Volume 3, Issue 2)
DOI 10.11648/j.sjph.20150302.26
Page(s) 265-268
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HIV, AIDs, Isoniazid Preventive Therapy

References
[1] WHO. Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings. Department of HIV/AIDS. Stop TB Department World Health Organization, Geneva, Switzerland
[2] Isoniazid preventive therapy (IPT) for people living with HIV. Consensus statement of the Core Group of the TB/HIV Working Group of the Stop TB Partnership
[3] Mark FC. INH Preventive Therapy (IPT) In HIV-Infected South African Children .Southern African Journal of HIV Medicine, Vol 12, No 2 (2011)
[4] World Health Organisation. Policy for Collaborative TB/HIV Activities
[5] Federal Ministry of Health .Department of Public Health. Guidelines ForClinical Management of TB/HIV related conditions In Nigeria 2nd edition,
[6] Golub JE. et al The impact of antiretroviral therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro, Brazil. AIDS 2007; 21: 1441-8 doi: 10.1097/QAD.0b013e328216f441 pmid: 17589190
[7] WHO. Policy statement on preventive therapy against tuberculosis in people living with HIV. Geneva: World Health Organization; 1998 (WHO/TB/98.255).
[8] Consensus statement of the core group of TB/HIV Working Group of STOP TB partnership. Geneva:StopTBpartnership. Availablfrom:http://www.stoptb.org/wg/tb_hiv/assets/documents/IPT%20Consensus%20Statement%20TB%20HIV%20Core%20Group.pdf
[9] Anand AD et al. Implementation of co-trimoxazole prophylaxis and isoniazid preventive therapy for people living with HIV. Bulletin of the World Health Organization 2010; 88:253-259. doi: 10.2471/BLT.09.066522
[10] Standards for Public Health; International Standards for Tuberculosis care: 2nd edition 2009
[11] Dye C, Watt CJ, Bleed DM, Hosseini SM, Raviglione MC. Evolution of tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally. Stop TB Department, World Health Organization, Geneva, Switzerland. dyec@who.int
[12] Comstock GW, Baum C, Snider DE Jr. Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies. US National Library of Medicine National Institutes of Health; PubMed
[13] Dye C, Watt CJ, Bleed DM, Hosseini SM, Raviglione MC. Evolution of tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally. Stop TB Department, World Health Organization, Geneva, Switzerland. dyec@who.int
[14] Namuwengea PM, J.K. Mukonzo JK, Kiwanuka N, Wanyenze R Byaruhanga R, Bissell K, et al. Loss to follow up from isoniazid preventive therapy among adults attending HIV voluntary counseling and testing sites in Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene journal home page: http/ /www.elsevier.com/locate/trstmh
[15] Marais BJ, Susan VZ, Schaaf HS, Aardt MV, Gie RP, and Beyers N. Adherence to isoniazid preventive chemotherapy: a prospective community based study.©2006 BMJ Publishing Group & Royal College of Paediatrics and Child Health Published online 2006 May 31. doi: 10.1136/adc.2006.097220
[16] WHO. Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial. Bulletin of the World Health Organisation
[17] Kathleen RP, Frangiscos S, Reuben MD, Wendy AC, Meg CD, Lynn F. et al. Improved Adherence and Less Toxicity With Rifampin vs Isoniazid for Treatment of Latent Tuberculosis.A Retrospective Study. Arch Intern Med. 2006; 166:1863-1870
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  • APA Style

    Nwokeukwu Huldah Ijeoma, Okorie Onuka, Emma-Ukaegbu Uloaku, Ukegbu Andrew, Nwogu Kelechukwu, et al. (2015). Use of Isoniazid Preventive Therapy on HIV/AIDS Patient in a Tertiary Health Facility South Eastern Nigeria. Science Journal of Public Health, 3(2), 265-268. https://doi.org/10.11648/j.sjph.20150302.26

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    ACS Style

    Nwokeukwu Huldah Ijeoma; Okorie Onuka; Emma-Ukaegbu Uloaku; Ukegbu Andrew; Nwogu Kelechukwu, et al. Use of Isoniazid Preventive Therapy on HIV/AIDS Patient in a Tertiary Health Facility South Eastern Nigeria. Sci. J. Public Health 2015, 3(2), 265-268. doi: 10.11648/j.sjph.20150302.26

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    AMA Style

    Nwokeukwu Huldah Ijeoma, Okorie Onuka, Emma-Ukaegbu Uloaku, Ukegbu Andrew, Nwogu Kelechukwu, et al. Use of Isoniazid Preventive Therapy on HIV/AIDS Patient in a Tertiary Health Facility South Eastern Nigeria. Sci J Public Health. 2015;3(2):265-268. doi: 10.11648/j.sjph.20150302.26

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  • @article{10.11648/j.sjph.20150302.26,
      author = {Nwokeukwu Huldah Ijeoma and Okorie Onuka and Emma-Ukaegbu Uloaku and Ukegbu Andrew and Nwogu Kelechukwu and Ajuogu Eno and Osunkwo Damaris and Asinobi Adanze},
      title = {Use of Isoniazid Preventive Therapy on HIV/AIDS Patient in a Tertiary Health Facility South Eastern Nigeria},
      journal = {Science Journal of Public Health},
      volume = {3},
      number = {2},
      pages = {265-268},
      doi = {10.11648/j.sjph.20150302.26},
      url = {https://doi.org/10.11648/j.sjph.20150302.26},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20150302.26},
      abstract = {Introduction: The Human Immuno-deficiency virus / Acquired immune-deficiency syndrome (HIV/AIDs) is a very serious disease and pandemic. There have been series of interventions to combat the disease and these include, Prevention of mother to child transmission, HIV counseling and testing, treatment of HIV/AIDs with antiretroviral drugs and the three I’s which include Intensive case search, Infection control and Isoniazid preventive therapy (IPT). There appears to be paucity of information on the IPT in our environment and it is therefore necessary to find out how the IPT has been implemented in this part of the world.  Objective: To determine the number of Cases of HIV placed on IPT. Methodology: This is a cross sectional study in which the HIV patients who were placed on the IPT were identified and followed up. The situational analysis was carried out to identify those already placed on IPT. The next stage was training of the doctors on IPT and informing them on the importance of IPT in the management of HIV patients. Data tools were provided. A focal person was selected to fill these data tools to be able to get accurate number of HIV patients on IPT. Data was analyzed with Microsoft Excel and Epi. Info. Results: The total number of new cases of HIV seen from July to September 2013 was 218, of which (30% N=65) was started on IPT. Of the 65 that started the IPT only (63%, N=41) continued the second month. The number of suspected TB were (2.3% N=5). The number of cases of TB- Co infection (0.4% N=1). Conclusion: The IPT is being utilized in this health facility for prevention of TB in HIV/AIDs although at a low rate, however the creation of more awareness among Doctors and Patients and proper documentation, will further improve the uptake of IPT.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Use of Isoniazid Preventive Therapy on HIV/AIDS Patient in a Tertiary Health Facility South Eastern Nigeria
    AU  - Nwokeukwu Huldah Ijeoma
    AU  - Okorie Onuka
    AU  - Emma-Ukaegbu Uloaku
    AU  - Ukegbu Andrew
    AU  - Nwogu Kelechukwu
    AU  - Ajuogu Eno
    AU  - Osunkwo Damaris
    AU  - Asinobi Adanze
    Y1  - 2015/03/12
    PY  - 2015
    N1  - https://doi.org/10.11648/j.sjph.20150302.26
    DO  - 10.11648/j.sjph.20150302.26
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 265
    EP  - 268
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20150302.26
    AB  - Introduction: The Human Immuno-deficiency virus / Acquired immune-deficiency syndrome (HIV/AIDs) is a very serious disease and pandemic. There have been series of interventions to combat the disease and these include, Prevention of mother to child transmission, HIV counseling and testing, treatment of HIV/AIDs with antiretroviral drugs and the three I’s which include Intensive case search, Infection control and Isoniazid preventive therapy (IPT). There appears to be paucity of information on the IPT in our environment and it is therefore necessary to find out how the IPT has been implemented in this part of the world.  Objective: To determine the number of Cases of HIV placed on IPT. Methodology: This is a cross sectional study in which the HIV patients who were placed on the IPT were identified and followed up. The situational analysis was carried out to identify those already placed on IPT. The next stage was training of the doctors on IPT and informing them on the importance of IPT in the management of HIV patients. Data tools were provided. A focal person was selected to fill these data tools to be able to get accurate number of HIV patients on IPT. Data was analyzed with Microsoft Excel and Epi. Info. Results: The total number of new cases of HIV seen from July to September 2013 was 218, of which (30% N=65) was started on IPT. Of the 65 that started the IPT only (63%, N=41) continued the second month. The number of suspected TB were (2.3% N=5). The number of cases of TB- Co infection (0.4% N=1). Conclusion: The IPT is being utilized in this health facility for prevention of TB in HIV/AIDs although at a low rate, however the creation of more awareness among Doctors and Patients and proper documentation, will further improve the uptake of IPT.
    VL  - 3
    IS  - 2
    ER  - 

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Author Information
  • Department of Community Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria

  • State Ministry of Health, Abia State, Nigeria

  • Department of Community Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria

  • Department of Community Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria

  • Department of Community Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria

  • Department of Community Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria

  • Department of Internal Medicine, National Hospital Abuja, Federal Capital Territory, Abuja

  • Department of Paediatrics, University College Hospital, Ibadan, Oyo State Nigeria

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