Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies
Science Journal of Public Health
Volume 4, Issue 2, March 2016, Pages: 81-87
Received: Feb. 3, 2016; Accepted: Feb. 17, 2016; Published: Mar. 1, 2016
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De-Sen Xiang, Department of General Surgery, Qianjiang Central Hospital of Chongqing Municipality, Chongqing, China
Jing Zhang, Department of General Surgery, Qianjiang Central Hospital of Chongqing Municipality, Chongqing, China
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The relationship between statin use and the risk of hepatocellular carcinoma (HCC) remains controversial. Therefore, we conducted a meta-analysis to clarify this issue. Data on the relationship between statin use and the risk of HCC were collected through an electronic search of PubMed database. Summary odds ratios (ORs) with 95% confidential intervals were calculated using a random-effects model. Six studies were selected for the final meta-analysis, involving 3778 cases and 482452 patients. Our meta-analysis showed that statin use was significantly associated with a decreased risk of HCC (OR, 0.60, 95% confidence interval, 0.48–0.76). In conclusion, the meta-analysis suggests that statin use is associated with a reduced risk of HCC. However, our findings should be interpreted with caution due to limited studies.
Statin, Hepatocellular Carcinoma, Meta-Analysis
To cite this article
De-Sen Xiang, Jing Zhang, Association Between Statin Use and Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies, Science Journal of Public Health. Vol. 4, No. 2, 2016, pp. 81-87. doi: 10.11648/j.sjph.20160402.11
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