Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease
Science Journal of Public Health
Volume 5, Issue 6, November 2017, Pages: 469-473
Received: Dec. 5, 2017; Published: Dec. 6, 2017
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Authors
Yuzhi Liu, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhenjiang Hou, Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Jingyu Zhang, Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Jianzhang Hou, Department of Surgery, Cangzhou People's Hospital, Cangzhou Medical College, Cangzhou, China
Hongsheng Wang, Diabetes Department of Endocrinology, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
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Abstract
In recent years, with the improvement of detection technology and medical level, the incidence of hypothyroidism, subclinical hypothyroidism and coronary heart disease was increasing year by year and patients were often associated with significant reduction of high-density lipoprotein cholesterol, increase of total cholesterol and Homocysteine and so on. But it was not clear whether there was a similar change occurs in patients with hypothyroidism complicated with coronary heart disease. The authors chose hospital patients, who were divided into a group of hypothyroidism complicated with coronary heart disease (merging group), a group of hypothyroidism, subclinical hypothyroidism and control group, with 60 cases in each group, to measure the blood lipid and Homocysteine, calculate blood lipid ratio and make analysis. As a result, the authors found that patients with hypothyroidism and merging group serum high-density lipoprotein cholesterol decreased. The levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, total cholesterol / high-density lipoprotein cholesterol, triglyceride / high-density lipoprotein cholesterol, low-density lipoprotein cholesterol / high-density lipoprotein cholesterol, lipid profile, non-high-density lipoprotein cholesterol and Homocysteine were significantly higher than the control group. And the group of patients with hypothyroidism complicated with coronary heart disease was higher than the hypothyroidism group. It came to the conclusion that dynamic monitoring of blood lipid and its ratio and the change of Homocysteine were important for clinical value in transforming subclinical hypothyroidism into hypothyroidism and predicting patients with hypothyroidism complicated with coronary heart disease.
Keywords
Hypothyroidism, Subclinical Hypothyroidism, Hypothyroidism Complicated with Coronary Heart Disease, Blood Lipid Ratio, Homocysteine
To cite this article
Yuzhi Liu, Zhenjiang Hou, Jingyu Zhang, Jianzhang Hou, Hongsheng Wang, Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease, Science Journal of Public Health. Vol. 5, No. 6, 2017, pp. 469-473. doi: 10.11648/j.sjph.20170506.20
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