Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study
Science Journal of Public Health
Volume 6, Issue 3, May 2018, Pages: 75-81
Received: May 10, 2018; Published: May 10, 2018
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Lidao Bao, Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Gaowa Sharen, Department of Ultrasound, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Sha Li, Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Xianhua Ren, Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Ruilian Ma, Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
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This study retrospectively analyzed antimicrobial prescription and concomitant economic outcomes in 28 Chinese state-owned hospitals before and after the intervention introduced by the Action Plan. The outcomes of national intervention were evaluated by analyzing statistics collected before and after the Action Plan which came into effect as of July 1, 2011. The fourth quarters of 2010 and 2011 were set as the baseline and intervention periods, respectively. The percentage of patients receiving antimicrobial prescription, the intensity of antimicrobials prescribed, economic indexes related to antimicrobial prescribing, and antimicrobial prophylaxis in clean surgical procedures were investigated, respectively. First, during the intervention period, the percentage of patients receiving antimicrobial treatment dropped to 15.6% and 49.1% in outpatient and inpatient settings, respectively. The intensity of antimicrobial prescribed decreased to 50.29 DDD (defined daily dose) in outpatient setting. The defined daily doses (DDDs) per thousand patients per day decreased to 12914.33 DDDs in outpatient settings. The results were statistically significant as compared to those in the baseline period (P<0.001). Second, the expenses on antimicrobials significantly decreased (P<0.001). Finally, the percentage of patients receiving antimicrobial prophylaxis for clean surgical procedures decreased to 48.94% (P<0.001), while the infection rates did not differ significantly (P=0.581). This multi-center study suggests that the Action Plan launched by China’s government proved effective in state-owned medical institutions in promoting rational antimicrobial prescription.
Antimicrobial Use, Multi-center Study, Action Plan
To cite this article
Lidao Bao, Gaowa Sharen, Sha Li, Xianhua Ren, Ruilian Ma, Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study, Science Journal of Public Health. Vol. 6, No. 3, 2018, pp. 75-81. doi: 10.11648/j.sjph.20180603.12
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