The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management
Science Journal of Public Health
Volume 6, Issue 4, July 2018, Pages: 116-119
Received: Sep. 16, 2018; Published: Sep. 18, 2018
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Authors
Zejun Zhou, Otolaryngology Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China
Fang Xu, Medical Examination Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China
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Abstract
Discus the management of Enhanced recovery after surgery,levels and clinical meaning of interleukin IL-18 and IL-6 in peripheral blood of patients with sleep apnea hypopnea syndrome (OSAHS). By ELISA to detect the levels of IL-18 and IL-6 in serum and peripheral blood mononuclear cells (PBMCs) supernatants of OSAHS patients and healthy controls and check the changes in serum IL-18 and IL-6 levels in OSAHS patients before and after Han uvulopalatopharyngoplasty (H-UPPP) treatment. The levels of IL-18 and IL-6 in serum and PBMCs supernatant of OSAHS patients were higher than those of the matched group (P <0.05). The levels of serum IL-18 and IL-6 increased with the severity of OSAHS, and the levels of IL-18 and IL-6 in serum and PBMCs supernatants were positively correlated (P <0.05). After 2 months of H-UPPP, the serum levels of IL-18, IL-6 and the index of respiratory disturbance were significantly lower than before the treatment (P <0. 05). The sleep quality and nocturnal hypoxia were significantly improved, and the lowest oxygen saturation was significantly higher than before the treatment (P <0.05). IL-18 and IL-6 may play an important role in the pathogenesis and prognosis of OSAHS.
Keywords
ERAS Management, Sleep Apnea, Hypoventilation Syndrome, IL-6, IL-18
To cite this article
Zejun Zhou, Fang Xu, The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management, Science Journal of Public Health. Vol. 6, No. 4, 2018, pp. 116-119. doi: 10.11648/j.sjph.20180604.14
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