Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism
Science Journal of Public Health
Volume 7, Issue 5, September 2019, Pages: 159-162
Received: Jul. 22, 2019;
Published: Sep. 27, 2019
Views 83 Downloads 15
Li Hongyan, Department of Medical Technology, Cangzhou Medical College, Cangzhou, China; Cangzhou Thyroid Disease Engineering Research Center, Cangzhou, China
Zhang Chunhui, Department of Blood Transfusion of Hejian People's Hospital, Cangzhou, China
Wang Hongsheng, Thyroid Diagnosis and Treatment Center of Cangzhou Traditional Chinese Medicine-Western Hospital, Cangzhou, China
Xu Qian, Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Objective: This paper is to explore the relationship between IL-2, IL-6, IL-8 and the development of hyperthyroidism and subclinical hyperthyroidism. Methods The serum levels of IL-2, IL-6 and IL-8 were determined in 251 cases of hyperthyroidism, 242 cases of subclinical hyperthyroidism and 130 cases of normal control. Results The level of IL-2 in hyperthyroidism group was significantly lower than that in the control group (P<0.01), and the levels of IL-6 and IL-8 were significantly higher than those in the control group (P<0.01); The level of IL-2 in subclinical hyperthyroidism group was lower than that in the control group (P<0.05), and the levels of IL-6 and IL-8 were higher than those in the control group (P<0.05). The level of IL-2 in hyperthyroidism group was lower than that in subclinical hyperthyroidism group, and the level of IL-6 and IL-8 were higher than those in subclinical hyperthyroidism group. The two groups of IL-2 were negatively correlated with serum FT3, FT 4, TT3, and TT4, and IL-6 and IL-8 were positively correlated with serum FT3, FT 4, TT3, and TT4. Conclusions IL-2, IL-6, and IL-8 all participated in the development process of hyperthyroidism and subclinical hypothyroidism, which contributed to the early discovery of subclinical hyperthyroidism.
Significance of Serum IL-2, IL-6 and IL-8 Detection in Patients with Hyperthyroidism and Subclinical Hyperthyroidism, Science Journal of Public Health.
Vol. 7, No. 5,
2019, pp. 159-162.
Hou Zhenjiang, Zhang Jingyu, Bian Yunzhuo, et al. Changes of serum lipid level, its ratio and cystatin C level in patients with hyperthyroidism and subclinical hyperthyroidism [J]. Shandong Medical Journal, 2017, 57 (39): 91-93.
Yu Tao. Dose effect of compound hyperthyroidism tablet in treatment of subclinical hyperthyroidism [J]. China Medicine and Pharmacy, 2017, 7 (2): 34-36.
Lu Zaiying, Zhong nanshan. Internal Medicine [M]. Beijing 7th Edition: People's Health Publishing House, 2012: 714.
Collet TH, Gussekloo J, Bauer DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality [J]. Arch Intern Med, 2012, 172 (10): 799-809.
Xu Xiaojin, Geng Jin, Hu Ting-ting, et al. Effect of subclinical hyperthyroidism on adverse cardiovascular events in patients with type 2 diabetes mellitus [J]. Shandong Medical Journal, 2017, 57 (14): 68-71.
Pang Aiping. The characteristics of patients with Graves disease complicated with hyperthyroidism heart disease and the clinical significance of related biochemical indicators [D]. Guangxi Medical University, 2018.
Wu Yajun, Huang Yong-de. Peptic ulcer with Hp infection and its relationship with serum IL-6, IL-8 and IL-2 [J]. Clinical Journal of Medical Officers, 2017, 45 (01): 38-41.
Li-Chao, Guo Qi. Changes of Serum IL-1β, IL-2, IL-6, IL-8 and TNF-α Levels in patients with epilepsy and clinical significance [J]. Journal of Preventive Medicine of Chinese People's Liberation Army, 2018, 36 (03): 375-377+385.
Ma Xiaolan, Wu Xuecheng, Zhang Shiyi. Observation of serum TNF, IL-6 and IL-8 levels in patients with hyperthyroidism and hypothyroidism [J]. Journal of Radioimmunology, 2002, 15 (3): 166.
Guo Jianlian, Liu Huina, Lu Long-kun, et al. The relationship between the levels of serum IL-2, IL-6, IL-8, TNF-α and bloodstream infection in critically ill patients [J]. Current Immunology, 2018, 38 (02): 120-123.
Zhang Yunming, Song Mingqiang. Changes of IL-2, IL-6, TNF concentration after 131I therapy in patients with hyperthyroidism from Graves’ disease [J]. Guide of China Medicine, 2013, 11 (2): 8-9.
Gao Haibo, Zhang Yawei, Hu Jiankang, et al. Effect of IL-2 and IL-6 levels on prognosis of 131 iodine treatment in Graves' patients [J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2016, (6): 716-718.
Wang Xiaoying, Gaolin, Liao Xin. et al. Relevance study between serum levels of Visfatin, IL-6 and TNF-alpha and thyroid function in patients with Graves' disease [J]. Guizhou Medical Journal, 2018, 42 (02: 162-163).
Shen J, Li Z, Li W, et a1. Thl, Th2, and Thl7 cytokine in—volvement in thyroid associated ophthalmopathy [J]. DisMarkers, 2015, 10 (7): 638-643.
Wei-Feng, Jiao Yanxiang, Guang Yan Qin, et al. Influence of different thyroid functional statuses on human serum IL-8, TNF Levels [J]. Journal of Radioimmunology, 2003 (04): 193-195.
Zhao Jiwei, Yang Lijuan, Sun Xuefeng. Advances in the study of the relationship between thyroid tumors and cytokines IL-4, IL-10, IFN-gamma and IL-17 [J]. Journal of Hebei North University (Natural Science Edition), 2015, 31 (3): 102-105.
Wang Junfang, Zhang Wei, Li Jing-li, et al. Effect of selenium on serum levels of TPOAb and TGAb in patients with Graves' disease [J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2013, 11 (04): 502-503.