Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window
Science Journal of Public Health
Volume 8, Issue 2, March 2020, Pages: 56-62
Received: Apr. 14, 2020; Published: May 29, 2020
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Authors
Wan Yingjun, Outpatient Department, Binzhou People's Hospital, Binzhou City, P. R. China
Ma Fengmei, Department of Infectious Diseases, Binzhou People's Hospital, Binzhou City, P. R. China
Zhao Changzhen, Department of Gynecology, Binzhou People's Hospital, Binzhou City, P. R. China
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Abstract
Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhibiting ovulation following PCOS ovulation induction treatment, 26 women exhibiting no ovulation following PCOS ovulation induction treatment, 38 women exhibiting oviduct obstruction, 32 women exhibiting hydrosalpinx. An immunohistochemical method was used to detect the expression of integrin and EGF in sterile women of the five groups of research objects during endometrial implantation window and a statistical analysis was conducted for all detection results. Results The expression level of the integrin in PCOS group is significantly lower than that in the control group and the difference is significant (P<0.05); the expression level of the integrin in PCOS anovulation group is significantly lower than that in PCOS ovulation group and there is statistical significance (P<0.05); the difference between the oviduct obstruction group and the control group is not significant (P>0.05); the expression level of the integrin in the hydrosalpinx group is lower than that in the oviduct obstruction group and the difference is significant (P<0.05). EGF is expressed in endometria of various groups of women and its expression is located in cytoplasm of epithelial cells of the endometrial gland. Conclusion Integrin and epidermal growth factor are expressed in endometria of various groups of women in the implantation phase indicating that they may be important regulatory factors for endometrial receptivity and embryonic implantation.
Keywords
Integrin, Epidermal Growth Factor, Sterile Women, Endometrium, Implantation Window Phase
To cite this article
Wan Yingjun, Ma Fengmei, Zhao Changzhen, Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window, Science Journal of Public Health. Vol. 8, No. 2, 2020, pp. 56-62. doi: 10.11648/j.sjph.20200802.15
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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