Science Journal of Public Health
Volume 3, Issue 5-1, September 2015, Pages: 20-24
Received: May 24, 2015;
Accepted: Jun. 26, 2015;
Published: Sep. 8, 2015
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Ahamefule Augustus Kelechi, Department of Biotechnology, Federal University of Technology, Owerri, Nigeria
Ezeji Ethelbert Uchechukwu, Department of Biotechnology, Federal University of Technology, Owerri, Nigeria
Most infectious diseases are known to be caused by microorganisms. The discovery of antimicrobial agents has saved the human race from a lot of sufferings due to the burden of these infectious diseases. Over the years, microorganisms have developed resistance to known antibiotics. Antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Factors responsible for antimicrobial resistance include changing microbial characteristics, selective pressures of antimicrobial use, as well as societal and technological changes that enhance the development and transmission of drug-resistant organisms. Microbial resistance to antibiotics can either be intrinsic or acquired. Different mechanisms of microbial resistance to known antibiotics have been proposed. These include antibiotic inactivation, ribosome protection, biofilm formation, target modification, reduced permeability to antimicrobial agents and increasing efflux of antibiotics from microbial cells. It is believed that the understanding of these mechanisms is important in the discovery of better ways to keep existing agents useful and also in the design of better antimicrobial agents that are not affected by the currently known, predicted, or unknown mechanisms of resistance.
Ahamefule Augustus Kelechi,
Ezeji Ethelbert Uchechukwu,
Mechanisms of Microbial Resistance to Known Antibiotics, Science Journal of Public Health. Special Issue: Who Is Afraid of the Microbes.
Vol. 3, No. 5-1,
2015, pp. 20-24.
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