Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver

Aliae AR Mohamed-Hussein; Mohamed-Eltaher AA Ibrahim

doi:doi:10.11648/j.sjph.s.2016040201.11

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Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver

Aliae AR Mohamed-Hussein, Mohamed-Eltaher AA Ibrahim

Published in Science Journal of Public Health (Volume 4, Issue 2-1)

Received: 4 July 2015 Accepted: 6 July 2015 Published: 8 September 2015

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Abstract

Obstructive sleep apnea syndrome (OSAS) may cause aggressive deterioration in the course of liver cirrhosis and may have an impact on the development of hepatic cell failure in patients with concomitant diseases. Patients and Methods: 34 patients with OSAS and compensated cirrhosis as well as 30 compensated cirrhotic patients were followed for 1 year to demonstrate the effect of hypoxia and body mass index (BMI) on their prognosis. Polysomnography, abdominal sonography, liver function tests and portal venous pressure were assessed on inclusion. Parameters of hepatic de-compensation (HD) as ascites, hepatic encephalopathy and bleeding esophageal varices (variceal hemorrhage) were recorded. Results: BMI was significantly higher in patients with concomitant OSAS and cirrhosis (p<0.01), and manifestations of hepatic de-compensation occurred in 32.3% of those cases compared to 10% in patients with cirrhosis alone (p<0.01) in one year. Positive correlations were recorded between BMI, desaturation index, sleep duration SpO2<90% and predictors of HD. Multivariate analysis showed that BMI, AHI, sleep duration SpO2< 90%, desaturation index were independent predictors of de-compensation, together with high portal venous pressure and lower serum albumin. Conclusion: Obesity and intermittent hypoxemia in OSAS may have deleterious effect on the natural history of compensated cirrhosis independent of portal venous pressure and liver function. Treatment of OSAS and weight reduction may decrease considerable burden on cirrhosis.

Published in	Science Journal of Public Health (Volume 4, Issue 2-1) This article belongs to the Special Issue Obstructive Sleep Apnea: A Systemic Disease
DOI	10.11648/j.sjph.s.2016040201.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

OSAS, Liver Cirrhosis, Ascites, Hepatic Encephalopathy, Variceal Hemorrhage, Obesity.

References

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APA Style

Aliae AR Mohamed-Hussein, Mohamed-Eltaher AA Ibrahim. (2015). Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver. Science Journal of Public Health, 4(2-1), 1-5. https://doi.org/10.11648/j.sjph.s.2016040201.11

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ACS Style

Aliae AR Mohamed-Hussein; Mohamed-Eltaher AA Ibrahim. Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver. Sci. J. Public Health 2015, 4(2-1), 1-5. doi: 10.11648/j.sjph.s.2016040201.11

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AMA Style

Aliae AR Mohamed-Hussein, Mohamed-Eltaher AA Ibrahim. Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver. Sci J Public Health. 2015;4(2-1):1-5. doi: 10.11648/j.sjph.s.2016040201.11

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@article{10.11648/j.sjph.s.2016040201.11,
  author = {Aliae AR Mohamed-Hussein and Mohamed-Eltaher AA Ibrahim},
  title = {Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver},
  journal = {Science Journal of Public Health},
  volume = {4},
  number = {2-1},
  pages = {1-5},
  doi = {10.11648/j.sjph.s.2016040201.11},
  url = {https://doi.org/10.11648/j.sjph.s.2016040201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.s.2016040201.11},
  abstract = {Obstructive sleep apnea syndrome (OSAS) may cause aggressive deterioration in the course of liver cirrhosis and may have an impact on the development of hepatic cell failure in patients with concomitant diseases. Patients and Methods: 34 patients with OSAS and compensated cirrhosis as well as 30 compensated cirrhotic patients were followed for 1 year to demonstrate the effect of hypoxia and body mass index (BMI) on their prognosis. Polysomnography, abdominal sonography, liver function tests and portal venous pressure were assessed on inclusion. Parameters of hepatic de-compensation (HD) as ascites, hepatic encephalopathy and bleeding esophageal varices (variceal hemorrhage) were recorded. Results: BMI was significantly higher in patients with concomitant OSAS and cirrhosis (p<0.01), and manifestations of hepatic de-compensation occurred in 32.3% of those cases compared to 10% in patients with cirrhosis alone (p<0.01) in one year. Positive correlations were recorded between BMI, desaturation index, sleep duration SpO2<90% and predictors of HD. Multivariate analysis showed that BMI, AHI, sleep duration SpO2< 90%, desaturation index were independent predictors of de-compensation, together with high portal venous pressure and lower serum albumin. Conclusion: Obesity and intermittent hypoxemia in OSAS may have deleterious effect on the natural history of compensated cirrhosis independent of portal venous pressure and liver function. Treatment of OSAS and weight reduction may decrease considerable burden on cirrhosis.},
 year = {2015}
}

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TY  - JOUR
T1  - Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver
AU  - Aliae AR Mohamed-Hussein
AU  - Mohamed-Eltaher AA Ibrahim
Y1  - 2015/09/08
PY  - 2015
N1  - https://doi.org/10.11648/j.sjph.s.2016040201.11
DO  - 10.11648/j.sjph.s.2016040201.11
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.s.2016040201.11
AB  - Obstructive sleep apnea syndrome (OSAS) may cause aggressive deterioration in the course of liver cirrhosis and may have an impact on the development of hepatic cell failure in patients with concomitant diseases. Patients and Methods: 34 patients with OSAS and compensated cirrhosis as well as 30 compensated cirrhotic patients were followed for 1 year to demonstrate the effect of hypoxia and body mass index (BMI) on their prognosis. Polysomnography, abdominal sonography, liver function tests and portal venous pressure were assessed on inclusion. Parameters of hepatic de-compensation (HD) as ascites, hepatic encephalopathy and bleeding esophageal varices (variceal hemorrhage) were recorded. Results: BMI was significantly higher in patients with concomitant OSAS and cirrhosis (p<0.01), and manifestations of hepatic de-compensation occurred in 32.3% of those cases compared to 10% in patients with cirrhosis alone (p<0.01) in one year. Positive correlations were recorded between BMI, desaturation index, sleep duration SpO2<90% and predictors of HD. Multivariate analysis showed that BMI, AHI, sleep duration SpO2< 90%, desaturation index were independent predictors of de-compensation, together with high portal venous pressure and lower serum albumin. Conclusion: Obesity and intermittent hypoxemia in OSAS may have deleterious effect on the natural history of compensated cirrhosis independent of portal venous pressure and liver function. Treatment of OSAS and weight reduction may decrease considerable burden on cirrhosis.
VL  - 4
IS  - 2-1
ER  -

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Author Information

Aliae AR Mohamed-Hussein

Chest Department, Assiut University Hospitals, Assiut, Egypt
Mohamed-Eltaher AA Ibrahim

Gastroenterology and Hepatology Department, Assiut University Hospitals, Assiut, Egypt

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APA Style

Aliae AR Mohamed-Hussein, Mohamed-Eltaher AA Ibrahim. (2015). Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver. Science Journal of Public Health, 4(2-1), 1-5. https://doi.org/10.11648/j.sjph.s.2016040201.11

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ACS Style

Aliae AR Mohamed-Hussein; Mohamed-Eltaher AA Ibrahim. Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver. Sci. J. Public Health 2015, 4(2-1), 1-5. doi: 10.11648/j.sjph.s.2016040201.11

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AMA Style

Aliae AR Mohamed-Hussein, Mohamed-Eltaher AA Ibrahim. Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver. Sci J Public Health. 2015;4(2-1):1-5. doi: 10.11648/j.sjph.s.2016040201.11

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@article{10.11648/j.sjph.s.2016040201.11,
  author = {Aliae AR Mohamed-Hussein and Mohamed-Eltaher AA Ibrahim},
  title = {Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver},
  journal = {Science Journal of Public Health},
  volume = {4},
  number = {2-1},
  pages = {1-5},
  doi = {10.11648/j.sjph.s.2016040201.11},
  url = {https://doi.org/10.11648/j.sjph.s.2016040201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.s.2016040201.11},
  abstract = {Obstructive sleep apnea syndrome (OSAS) may cause aggressive deterioration in the course of liver cirrhosis and may have an impact on the development of hepatic cell failure in patients with concomitant diseases. Patients and Methods: 34 patients with OSAS and compensated cirrhosis as well as 30 compensated cirrhotic patients were followed for 1 year to demonstrate the effect of hypoxia and body mass index (BMI) on their prognosis. Polysomnography, abdominal sonography, liver function tests and portal venous pressure were assessed on inclusion. Parameters of hepatic de-compensation (HD) as ascites, hepatic encephalopathy and bleeding esophageal varices (variceal hemorrhage) were recorded. Results: BMI was significantly higher in patients with concomitant OSAS and cirrhosis (p<0.01), and manifestations of hepatic de-compensation occurred in 32.3% of those cases compared to 10% in patients with cirrhosis alone (p<0.01) in one year. Positive correlations were recorded between BMI, desaturation index, sleep duration SpO2<90% and predictors of HD. Multivariate analysis showed that BMI, AHI, sleep duration SpO2< 90%, desaturation index were independent predictors of de-compensation, together with high portal venous pressure and lower serum albumin. Conclusion: Obesity and intermittent hypoxemia in OSAS may have deleterious effect on the natural history of compensated cirrhosis independent of portal venous pressure and liver function. Treatment of OSAS and weight reduction may decrease considerable burden on cirrhosis.},
 year = {2015}
}

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TY  - JOUR
T1  - Obstructive Sleep Apnoea: Another Burden on Cirrhotic Liver
AU  - Aliae AR Mohamed-Hussein
AU  - Mohamed-Eltaher AA Ibrahim
Y1  - 2015/09/08
PY  - 2015
N1  - https://doi.org/10.11648/j.sjph.s.2016040201.11
DO  - 10.11648/j.sjph.s.2016040201.11
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.s.2016040201.11
AB  - Obstructive sleep apnea syndrome (OSAS) may cause aggressive deterioration in the course of liver cirrhosis and may have an impact on the development of hepatic cell failure in patients with concomitant diseases. Patients and Methods: 34 patients with OSAS and compensated cirrhosis as well as 30 compensated cirrhotic patients were followed for 1 year to demonstrate the effect of hypoxia and body mass index (BMI) on their prognosis. Polysomnography, abdominal sonography, liver function tests and portal venous pressure were assessed on inclusion. Parameters of hepatic de-compensation (HD) as ascites, hepatic encephalopathy and bleeding esophageal varices (variceal hemorrhage) were recorded. Results: BMI was significantly higher in patients with concomitant OSAS and cirrhosis (p<0.01), and manifestations of hepatic de-compensation occurred in 32.3% of those cases compared to 10% in patients with cirrhosis alone (p<0.01) in one year. Positive correlations were recorded between BMI, desaturation index, sleep duration SpO2<90% and predictors of HD. Multivariate analysis showed that BMI, AHI, sleep duration SpO2< 90%, desaturation index were independent predictors of de-compensation, together with high portal venous pressure and lower serum albumin. Conclusion: Obesity and intermittent hypoxemia in OSAS may have deleterious effect on the natural history of compensated cirrhosis independent of portal venous pressure and liver function. Treatment of OSAS and weight reduction may decrease considerable burden on cirrhosis.
VL  - 4
IS  - 2-1
ER  -

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