Sero - Prevalence of <i>Helicobacter Pylori</i> in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia

Brhanu Teka; Solomon Gebre - Selassie; Tamrat Abebe

doi:doi:10.11648/j.sjph.20160405.14

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Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia

Brhanu Teka, Solomon Gebre - Selassie, Tamrat Abebe

Published in Science Journal of Public Health (Volume 4, Issue 5)

Received: 7 September 2015 Accepted: 21 September 2015 Published: 17 August 2016

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Abstract

Background. Helicobacter pylori (H. pylori) is recognized as a major human pathogen. Clinical symptoms associated with H. pylori infection have been reported in patients with human immunodeficiency virus (HIV). A high, normal, and a lower sero - prevalence of H. pylori infection in HIV positive patients than negative controls was found in different studies. The aim of this study was to assess the sero - prevalence of H. pylori infection in HIV positive patients and negative controls and determine the impact of CD4 cell count in patients with H. pylori in St. Paul’s General Specialized Hospital in Addis Ababa, Ethiopia. Methods. A comparative cross sectional study was conducted in HIV positive patients and controls with gastrointestinal symptoms using Serology test kit (ACON^® H. pylori, USA). All individuals who came to Voluntary Counselling and Testing and Anti - Retroviral Therapy to the Out Patient Department of the hospital were examined for complaints of dyspepsia and those with the complaint were tested for H. pylori. Results. Of the 106 HIV positive subjects, 68 (64.2%) were positive for anti - H. pylori IgG antibodies; and of the 106 HIV negative controls, 52 (49.1%) were positive for anti - H. pylori IgG antibodies (p=0.037). There was no significant difference of H. pylori seroprevalence between relatively higher and lower CD4 cell counts in the HIV positive cases (p>0.05). Conclusion. A significantly higher seroprevalence of H. pylori was demonstrated in the HIV positive subjects. There was no significant difference in the prevalence of H. pylori between different CD4+ cell counts in the HIV positive study group.

Published in	Science Journal of Public Health (Volume 4, Issue 5)
DOI	10.11648/j.sjph.20160405.14
Page(s)	387-393
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Helicobacter Pylori, Sero - Prevalence, HIV, CD4 Count, Dyspepsia

References

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[6]	Romanelli F., Smith KM. and Murphy B. S. (2007). Does HIV Infection Alter the Incidence or Pathology of Helicobacter pylori Infection? AIDS patient care and STDs. 21 (12): 908-19.
[7]	Marano BJ Jr., Smith F. and Bonauno C. A. (1993). Helicobacter pylori prevalence in acquired immunodeficiency syndrome. Am.J.Gastroenterology. 88: 687-690.
[8]	Mach T, Skwara P, Biesiada G, Cieśla A, Macura A. (2007). Morphological changes of the upper gastrointestinal tract mucosa and Helicobacter pylori infection in HIV-positive patients with severe immunodeficiency and symptoms of dyspepsia. Med Sci Monit. 13 (1): CR14-9).
[9]	Lichterfeld M., Lorenz C., Nischalke H D., Scheurlen Ch., Sauerbruch T., Rockstroh J K. (2002). Decreased Prevalence of Helicobacter pylori Infection in HIV Patients with AIDS defining Diseases. Z Gastroenterol. 40 (1): 11-14.
[10]	Panos GZ., Xirouchakis E., Tzias V., Charatsis G., Bliziotis IA., Doulgeroglou V., Margetis N., Falagas ME. (2007). Helicobacter pylori infection in symptomatic HIV-seropositive and seronegative patients: a case-control study. AIDS Res Hum Retroviruses. 23 (5): 709-12.
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[13]	Nielsen H., Andersen LP. (2009). Sero-diagnosis of Helicobacter pylori infection in patients with human immunodeficiency virus infection. APMIS. 103, 7-8: 689–692.
[14]	Francis N D., Logan R P H., Walker MM., Polson RJ., Boylston A W., Pinching A J., Harris J R W., Baron J H. (1990). Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-1 infection. J Clin Pathol. 43: 60-62.
[15]	Luo HB., Hu ZW., Guo JW., (2009). Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages. Journal of southern medical university. 29 (7): 1397-9.
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APA Style

Brhanu Teka, Solomon Gebre - Selassie, Tamrat Abebe. (2016). Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia. Science Journal of Public Health, 4(5), 387-393. https://doi.org/10.11648/j.sjph.20160405.14

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ACS Style

Brhanu Teka; Solomon Gebre - Selassie; Tamrat Abebe. Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia. Sci. J. Public Health 2016, 4(5), 387-393. doi: 10.11648/j.sjph.20160405.14

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AMA Style

Brhanu Teka, Solomon Gebre - Selassie, Tamrat Abebe. Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia. Sci J Public Health. 2016;4(5):387-393. doi: 10.11648/j.sjph.20160405.14

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@article{10.11648/j.sjph.20160405.14,
  author = {Brhanu Teka and Solomon Gebre - Selassie and Tamrat Abebe},
  title = {Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia},
  journal = {Science Journal of Public Health},
  volume = {4},
  number = {5},
  pages = {387-393},
  doi = {10.11648/j.sjph.20160405.14},
  url = {https://doi.org/10.11648/j.sjph.20160405.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20160405.14},
  abstract = {Background. Helicobacter pylori (H. pylori) is recognized as a major human pathogen. Clinical symptoms associated with H. pylori infection have been reported in patients with human immunodeficiency virus (HIV). A high, normal, and a lower sero - prevalence of H. pylori infection in HIV positive patients than negative controls was found in different studies. The aim of this study was to assess the sero - prevalence of H. pylori infection in HIV positive patients and negative controls and determine the impact of CD4 cell count in patients with H. pylori in St. Paul’s General Specialized Hospital in Addis Ababa, Ethiopia. Methods. A comparative cross sectional study was conducted in HIV positive patients and controls with gastrointestinal symptoms using Serology test kit (ACON® H. pylori, USA). All individuals who came to Voluntary Counselling and Testing and Anti - Retroviral Therapy to the Out Patient Department of the hospital were examined for complaints of dyspepsia and those with the complaint were tested for H. pylori. Results. Of the 106 HIV positive subjects, 68 (64.2%) were positive for anti - H. pylori IgG antibodies; and of the 106 HIV negative controls, 52 (49.1%) were positive for anti - H. pylori IgG antibodies (p=0.037). There was no significant difference of H. pylori seroprevalence between relatively higher and lower CD4 cell counts in the HIV positive cases (p>0.05). Conclusion. A significantly higher seroprevalence of H. pylori was demonstrated in the HIV positive subjects. There was no significant difference in the prevalence of H. pylori between different CD4+ cell counts in the HIV positive study group.},
 year = {2016}
}

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TY - JOUR
T1 - Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia
AU - Brhanu Teka
AU - Solomon Gebre - Selassie
AU - Tamrat Abebe
Y1 - 2016/08/17
PY - 2016
N1 - https://doi.org/10.11648/j.sjph.20160405.14
DO - 10.11648/j.sjph.20160405.14
T2 - Science Journal of Public Health
JF - Science Journal of Public Health
JO - Science Journal of Public Health
SP - 387
EP - 393
PB - Science Publishing Group
SN - 2328-7950
UR - https://doi.org/10.11648/j.sjph.20160405.14
AB - Background. Helicobacter pylori (H. pylori) is recognized as a major human pathogen. Clinical symptoms associated with H. pylori infection have been reported in patients with human immunodeficiency virus (HIV). A high, normal, and a lower sero - prevalence of H. pylori infection in HIV positive patients than negative controls was found in different studies. The aim of this study was to assess the sero - prevalence of H. pylori infection in HIV positive patients and negative controls and determine the impact of CD4 cell count in patients with H. pylori in St. Paul’s General Specialized Hospital in Addis Ababa, Ethiopia. Methods. A comparative cross sectional study was conducted in HIV positive patients and controls with gastrointestinal symptoms using Serology test kit (ACON® H. pylori, USA). All individuals who came to Voluntary Counselling and Testing and Anti - Retroviral Therapy to the Out Patient Department of the hospital were examined for complaints of dyspepsia and those with the complaint were tested for H. pylori. Results. Of the 106 HIV positive subjects, 68 (64.2%) were positive for anti - H. pylori IgG antibodies; and of the 106 HIV negative controls, 52 (49.1%) were positive for anti - H. pylori IgG antibodies (p=0.037). There was no significant difference of H. pylori seroprevalence between relatively higher and lower CD4 cell counts in the HIV positive cases (p>0.05). Conclusion. A significantly higher seroprevalence of H. pylori was demonstrated in the HIV positive subjects. There was no significant difference in the prevalence of H. pylori between different CD4+ cell counts in the HIV positive study group.
VL - 4
IS - 5
ER -

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Author Information

Brhanu Teka

Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
Solomon Gebre - Selassie

Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
Tamrat Abebe

Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia

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APA Style

Brhanu Teka, Solomon Gebre - Selassie, Tamrat Abebe. (2016). Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia. Science Journal of Public Health, 4(5), 387-393. https://doi.org/10.11648/j.sjph.20160405.14

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ACS Style

Brhanu Teka; Solomon Gebre - Selassie; Tamrat Abebe. Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia. Sci. J. Public Health 2016, 4(5), 387-393. doi: 10.11648/j.sjph.20160405.14

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AMA Style

Brhanu Teka, Solomon Gebre - Selassie, Tamrat Abebe. Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia. Sci J Public Health. 2016;4(5):387-393. doi: 10.11648/j.sjph.20160405.14

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@article{10.11648/j.sjph.20160405.14,
  author = {Brhanu Teka and Solomon Gebre - Selassie and Tamrat Abebe},
  title = {Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia},
  journal = {Science Journal of Public Health},
  volume = {4},
  number = {5},
  pages = {387-393},
  doi = {10.11648/j.sjph.20160405.14},
  url = {https://doi.org/10.11648/j.sjph.20160405.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20160405.14},
  abstract = {Background. Helicobacter pylori (H. pylori) is recognized as a major human pathogen. Clinical symptoms associated with H. pylori infection have been reported in patients with human immunodeficiency virus (HIV). A high, normal, and a lower sero - prevalence of H. pylori infection in HIV positive patients than negative controls was found in different studies. The aim of this study was to assess the sero - prevalence of H. pylori infection in HIV positive patients and negative controls and determine the impact of CD4 cell count in patients with H. pylori in St. Paul’s General Specialized Hospital in Addis Ababa, Ethiopia. Methods. A comparative cross sectional study was conducted in HIV positive patients and controls with gastrointestinal symptoms using Serology test kit (ACON® H. pylori, USA). All individuals who came to Voluntary Counselling and Testing and Anti - Retroviral Therapy to the Out Patient Department of the hospital were examined for complaints of dyspepsia and those with the complaint were tested for H. pylori. Results. Of the 106 HIV positive subjects, 68 (64.2%) were positive for anti - H. pylori IgG antibodies; and of the 106 HIV negative controls, 52 (49.1%) were positive for anti - H. pylori IgG antibodies (p=0.037). There was no significant difference of H. pylori seroprevalence between relatively higher and lower CD4 cell counts in the HIV positive cases (p>0.05). Conclusion. A significantly higher seroprevalence of H. pylori was demonstrated in the HIV positive subjects. There was no significant difference in the prevalence of H. pylori between different CD4+ cell counts in the HIV positive study group.},
 year = {2016}
}

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