Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia
American Journal of Internal Medicine
Volume 1, Issue 2, July 2013, Pages: 10-13
Received: Jun. 16, 2013;
Published: Jul. 10, 2013
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Igor Zhurakovsky, Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia
Sergey Arkhypov, Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia
Marya Pustovetova, Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia
Igor Marinkin, Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia
Tatyana Kunts, Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia
Inflammatory process is not limited only local effects but could affect other organs and tissues. In this study, we investigated the influence of experimental tibial osteomyelitis on skin cells in dynamics. Although the skin located at the distance from the infection nidus it supposed to manifest intensive proliferation, reparation and apoptosis under adverse factors. Immunohistochemical assay of apoptotic regulators and proliferation-related proteins was carried out in fibroblasts of stratum reticulare in Wistar rats. Proliferating fibroblasts pool decrease confirmed by Ki67 expression decrease was revealed, overexpression of p53 and Bax was accompanied by Bcl-2 expression decrease. Findings suggest depressed regeneratory potential of fibroblasts, high probability of apoptosis in the skin cells at the persisting osteomyelitis that should be considered in dermatological practice.
Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia, American Journal of Internal Medicine.
Vol. 1, No. 2,
2013, pp. 10-13.
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