American Journal of Internal Medicine

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Determination of Netrin-1 Levels in Patients that Applied to Emergency Department with Stroke and Its Effects on Survival for 6 Months

Received: 18 November 2014    Accepted: 19 December 2014    Published: 27 December 2014
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Abstract

Introduction: We aimed to observe whether there are differences in patients presenting to the emergency department that has stroke, determination of serum levels of netrin-1, and its impact on patient survival and determine the effect on survival and stroke patients according to the type of netrin-1 levels. Methods: The study was held in the Konya Education and Research Hospital, Emergency Department between 1st of August, 2012 and 30th of November, 2012. Patients divided into sub groups after determination of hemorrhagic and ischemic stroke. Control group was created with the patients that did not have stroke. In both groups, Netrin-1 levels were studied. Findings: Totally 131 stroke 51 control patiens were enrolled the study. %13 of the patients were with hemorrhagic where as the other %87 was ischemic stroke. In the stroke group Netrin-1 was lower than the control group (p=0,003 and p<0,001). In order to distinguish between control and case groups, related with Netrin-1 ROC curve was statistically significant 0,739 (%95 Confidence Interval: 0,664-0,814). Best cutoff point for Netrin-1 is determined as 728.4. The sensitivity of Netrin-1 at this point is %71,0; selectivity is %68,6; positive predictive value is %85,3; negative predictive value is %47,9; and finally accuracy rate was found as %70,3. Although in the hemorrhagic stroke Netrin-1 is lower than ischemic stroke, the difference between groups was not statistically significant (p=0,297). There was not statistically significant difference in terms with among the patients the median survival and die patients related with Netrin-1. Discussion: Netrin-1 precursor protein is important for neural and vascular development. Netrin-1 regulates cell migration and axon in the brain in utero. On the other hand, in the SSS damage, injured in sections the migration of adult neural stem cells is located. In determining the prognosis of stroke and mortality in the literature, many markers are used. Result: Our study is the first study on this subject in stroke patients have low levels of netrin-1. According to the type of stroke did not detect a difference in netrin-1 levels. Netrin-1 levels were not associated with mortality.

DOI 10.11648/j.ajim.20140206.19
Published in American Journal of Internal Medicine (Volume 2, Issue 6, November 2014)
Page(s) 150-155
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Stroke, Netrin-1, Survival

References
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Author Information
  • Konya Training and Research Hospital, Emergency Department, Konya, Turkey

  • Konya Training and Research Hospital, Emergency Department, Konya, Turkey

  • Konya Training and Research Hospital, Emergency Department, Konya, Turkey

  • Konya Training and Research Hospital, Emergency Department, Konya, Turkey

  • Konya Training and Research Hospital, Emergency Department, Konya, Turkey

  • Konya Training and Research Hospital, Biochemistry Department, Konya, Turkey

  • Konya Training and Research Hospital, Neurology Department, Konya, Turkey

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  • APA Style

    Korhan Ivelik, Ramazan Koylu, Akinci Emine, Basar Cander, Zerrin Defne Dundar, et al. (2014). Determination of Netrin-1 Levels in Patients that Applied to Emergency Department with Stroke and Its Effects on Survival for 6 Months. American Journal of Internal Medicine, 2(6), 150-155. https://doi.org/10.11648/j.ajim.20140206.19

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    Korhan Ivelik; Ramazan Koylu; Akinci Emine; Basar Cander; Zerrin Defne Dundar, et al. Determination of Netrin-1 Levels in Patients that Applied to Emergency Department with Stroke and Its Effects on Survival for 6 Months. Am. J. Intern. Med. 2014, 2(6), 150-155. doi: 10.11648/j.ajim.20140206.19

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    AMA Style

    Korhan Ivelik, Ramazan Koylu, Akinci Emine, Basar Cander, Zerrin Defne Dundar, et al. Determination of Netrin-1 Levels in Patients that Applied to Emergency Department with Stroke and Its Effects on Survival for 6 Months. Am J Intern Med. 2014;2(6):150-155. doi: 10.11648/j.ajim.20140206.19

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  • @article{10.11648/j.ajim.20140206.19,
      author = {Korhan Ivelik and Ramazan Koylu and Akinci Emine and Basar Cander and Zerrin Defne Dundar and Oznur Koylu and Haluk Gumus},
      title = {Determination of Netrin-1 Levels in Patients that Applied to Emergency Department with Stroke and Its Effects on Survival for 6 Months},
      journal = {American Journal of Internal Medicine},
      volume = {2},
      number = {6},
      pages = {150-155},
      doi = {10.11648/j.ajim.20140206.19},
      url = {https://doi.org/10.11648/j.ajim.20140206.19},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.20140206.19},
      abstract = {Introduction: We aimed to observe whether there are differences in patients presenting to the emergency department that has stroke, determination of serum levels of netrin-1, and its impact on patient survival and determine the effect on survival and stroke patients according to the type of netrin-1 levels. Methods: The study was held in the Konya Education and Research Hospital, Emergency Department between 1st of August, 2012 and 30th of November, 2012. Patients divided into sub groups after determination of hemorrhagic and ischemic stroke. Control group was created with the patients that did not have stroke. In both groups, Netrin-1 levels were  studied. Findings: Totally 131 stroke 51 control patiens were enrolled the study. %13 of the patients were with hemorrhagic where as the other %87 was ischemic stroke. In the stroke group Netrin-1 was lower than the control group (p=0,003 and p<0,001). In order to distinguish between control and case groups, related with Netrin-1 ROC curve was statistically significant 0,739 (%95 Confidence Interval: 0,664-0,814). Best cutoff point for Netrin-1 is determined as 728.4. The sensitivity of Netrin-1 at this point is %71,0; selectivity is %68,6; positive predictive value is %85,3; negative predictive value is %47,9; and finally accuracy rate was found as %70,3. Although in the hemorrhagic stroke Netrin-1 is lower than ischemic stroke, the difference between groups was not statistically significant (p=0,297). There was not statistically significant difference in terms with among the patients the median survival and die patients related with Netrin-1. Discussion: Netrin-1 precursor protein is important for neural and vascular development. Netrin-1 regulates cell migration and axon in the brain in utero. On the other hand, in the SSS damage, injured in sections the migration of adult neural stem cells is located. In determining the prognosis of stroke and mortality in the literature, many markers are used. Result: Our study is the first study on this subject in stroke patients have low levels of netrin-1. According to the type of stroke did not detect a difference in netrin-1 levels. Netrin-1 levels were not associated with mortality.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Determination of Netrin-1 Levels in Patients that Applied to Emergency Department with Stroke and Its Effects on Survival for 6 Months
    AU  - Korhan Ivelik
    AU  - Ramazan Koylu
    AU  - Akinci Emine
    AU  - Basar Cander
    AU  - Zerrin Defne Dundar
    AU  - Oznur Koylu
    AU  - Haluk Gumus
    Y1  - 2014/12/27
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajim.20140206.19
    DO  - 10.11648/j.ajim.20140206.19
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 150
    EP  - 155
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20140206.19
    AB  - Introduction: We aimed to observe whether there are differences in patients presenting to the emergency department that has stroke, determination of serum levels of netrin-1, and its impact on patient survival and determine the effect on survival and stroke patients according to the type of netrin-1 levels. Methods: The study was held in the Konya Education and Research Hospital, Emergency Department between 1st of August, 2012 and 30th of November, 2012. Patients divided into sub groups after determination of hemorrhagic and ischemic stroke. Control group was created with the patients that did not have stroke. In both groups, Netrin-1 levels were  studied. Findings: Totally 131 stroke 51 control patiens were enrolled the study. %13 of the patients were with hemorrhagic where as the other %87 was ischemic stroke. In the stroke group Netrin-1 was lower than the control group (p=0,003 and p<0,001). In order to distinguish between control and case groups, related with Netrin-1 ROC curve was statistically significant 0,739 (%95 Confidence Interval: 0,664-0,814). Best cutoff point for Netrin-1 is determined as 728.4. The sensitivity of Netrin-1 at this point is %71,0; selectivity is %68,6; positive predictive value is %85,3; negative predictive value is %47,9; and finally accuracy rate was found as %70,3. Although in the hemorrhagic stroke Netrin-1 is lower than ischemic stroke, the difference between groups was not statistically significant (p=0,297). There was not statistically significant difference in terms with among the patients the median survival and die patients related with Netrin-1. Discussion: Netrin-1 precursor protein is important for neural and vascular development. Netrin-1 regulates cell migration and axon in the brain in utero. On the other hand, in the SSS damage, injured in sections the migration of adult neural stem cells is located. In determining the prognosis of stroke and mortality in the literature, many markers are used. Result: Our study is the first study on this subject in stroke patients have low levels of netrin-1. According to the type of stroke did not detect a difference in netrin-1 levels. Netrin-1 levels were not associated with mortality.
    VL  - 2
    IS  - 6
    ER  - 

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