Insulin resistance plays an essential role in the pathogenesis of diabetes associated with HCV. High levels of inflammatory cytokines have been found in HCV-infected patients. The aim of the study was to investigate the association of HCV infection with impaired glucose metabolism and to highlight the role of inflammatory cytokines as an initial mechanism involved in insulin resistance development in HCV infection. It included 3 groups of patients: Group I: 50 HCV patients with DM. Group II: 50 HCV patients without DM and Group III: 25 patients with DM alone as control subjects. Insulin resistance was evaluated using the (HOMA - IR) index. We measured the levels of fasting insulin, CRP and two of the inflammatory cytokines of the innate immunity (TNF-α and IL-6 by ELISA). It was found that insulin resistance, CRP and IL6 in group (I) were significantly higher when compared to group (II) and (III) with P-value < 0.001. CRP in group (II) was significantly higher when compared to group (III) with P-value < 0.05. Serum level of (TNF-α) in group (I) was significantly higher when compared to group (II) with P-value < 0.05 and group (III) with P-value < 0.001 as well as in group (II) it was significantly higher when compared to group (III) with P-value < 0.001. CRP, IL-6 and TNF-α had statistically significant positive direct correlation to insulin resistance. In conclusion there was a strong relationship between inflammatory cytokines and the occurrence of insulin resistance in chronic HCV patients with type 2 diabetes mellitus.
| Published in | American Journal of Internal Medicine (Volume 4, Issue 5) |
| DOI | 10.11648/j.ajim.20160405.11 |
| Page(s) | 79-84 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Diabetes, Inflammatory Cytokines, Insulin Resistance and Chronic HCV Infection
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APA Style
Nouman Mohammed Elgarem, Mohammad Ahmad Elghobary, Rasha Hamed El Sherif, Maha Assem Hussien, Yousra Hamed Mourad. (2016). Role of Inflammatory Cytokines in Insulin Resistance Among Chronic Hepatitis C Patients. American Journal of Internal Medicine, 4(5), 79-84. https://doi.org/10.11648/j.ajim.20160405.11
ACS Style
Nouman Mohammed Elgarem; Mohammad Ahmad Elghobary; Rasha Hamed El Sherif; Maha Assem Hussien; Yousra Hamed Mourad. Role of Inflammatory Cytokines in Insulin Resistance Among Chronic Hepatitis C Patients. Am. J. Intern. Med. 2016, 4(5), 79-84. doi: 10.11648/j.ajim.20160405.11
AMA Style
Nouman Mohammed Elgarem, Mohammad Ahmad Elghobary, Rasha Hamed El Sherif, Maha Assem Hussien, Yousra Hamed Mourad. Role of Inflammatory Cytokines in Insulin Resistance Among Chronic Hepatitis C Patients. Am J Intern Med. 2016;4(5):79-84. doi: 10.11648/j.ajim.20160405.11
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Download@article{10.11648/j.ajim.20160405.11,
author = {Nouman Mohammed Elgarem and Mohammad Ahmad Elghobary and Rasha Hamed El Sherif and Maha Assem Hussien and Yousra Hamed Mourad},
title = {Role of Inflammatory Cytokines in Insulin Resistance Among Chronic Hepatitis C Patients},
journal = {American Journal of Internal Medicine},
volume = {4},
number = {5},
pages = {79-84},
doi = {10.11648/j.ajim.20160405.11},
url = {https://doi.org/10.11648/j.ajim.20160405.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20160405.11},
abstract = {Insulin resistance plays an essential role in the pathogenesis of diabetes associated with HCV. High levels of inflammatory cytokines have been found in HCV-infected patients. The aim of the study was to investigate the association of HCV infection with impaired glucose metabolism and to highlight the role of inflammatory cytokines as an initial mechanism involved in insulin resistance development in HCV infection. It included 3 groups of patients: Group I: 50 HCV patients with DM. Group II: 50 HCV patients without DM and Group III: 25 patients with DM alone as control subjects. Insulin resistance was evaluated using the (HOMA - IR) index. We measured the levels of fasting insulin, CRP and two of the inflammatory cytokines of the innate immunity (TNF-α and IL-6 by ELISA). It was found that insulin resistance, CRP and IL6 in group (I) were significantly higher when compared to group (II) and (III) with P-value < 0.001. CRP in group (II) was significantly higher when compared to group (III) with P-value < 0.05. Serum level of (TNF-α) in group (I) was significantly higher when compared to group (II) with P-value < 0.05 and group (III) with P-value < 0.001 as well as in group (II) it was significantly higher when compared to group (III) with P-value < 0.001. CRP, IL-6 and TNF-α had statistically significant positive direct correlation to insulin resistance. In conclusion there was a strong relationship between inflammatory cytokines and the occurrence of insulin resistance in chronic HCV patients with type 2 diabetes mellitus.},
year = {2016}
}
TY - JOUR T1 - Role of Inflammatory Cytokines in Insulin Resistance Among Chronic Hepatitis C Patients AU - Nouman Mohammed Elgarem AU - Mohammad Ahmad Elghobary AU - Rasha Hamed El Sherif AU - Maha Assem Hussien AU - Yousra Hamed Mourad Y1 - 2016/08/31 PY - 2016 N1 - https://doi.org/10.11648/j.ajim.20160405.11 DO - 10.11648/j.ajim.20160405.11 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 79 EP - 84 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20160405.11 AB - Insulin resistance plays an essential role in the pathogenesis of diabetes associated with HCV. High levels of inflammatory cytokines have been found in HCV-infected patients. The aim of the study was to investigate the association of HCV infection with impaired glucose metabolism and to highlight the role of inflammatory cytokines as an initial mechanism involved in insulin resistance development in HCV infection. It included 3 groups of patients: Group I: 50 HCV patients with DM. Group II: 50 HCV patients without DM and Group III: 25 patients with DM alone as control subjects. Insulin resistance was evaluated using the (HOMA - IR) index. We measured the levels of fasting insulin, CRP and two of the inflammatory cytokines of the innate immunity (TNF-α and IL-6 by ELISA). It was found that insulin resistance, CRP and IL6 in group (I) were significantly higher when compared to group (II) and (III) with P-value < 0.001. CRP in group (II) was significantly higher when compared to group (III) with P-value < 0.05. Serum level of (TNF-α) in group (I) was significantly higher when compared to group (II) with P-value < 0.05 and group (III) with P-value < 0.001 as well as in group (II) it was significantly higher when compared to group (III) with P-value < 0.001. CRP, IL-6 and TNF-α had statistically significant positive direct correlation to insulin resistance. In conclusion there was a strong relationship between inflammatory cytokines and the occurrence of insulin resistance in chronic HCV patients with type 2 diabetes mellitus. VL - 4 IS - 5 ER -
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