Pulmonary histiocytic sarcoma is a rare, but highly malignant disease. Its low incidence imposes significant difficulties on physicians confronted with affected patients. The reported patient is a 24-year old male with histiocytic sarcoma of the lung. Left lower lobectomy was performed. Histologically, tumor cells had no features of carcinoma. Several entities were raised as differentials: large B or T cell lymphomas, metastatic melanoma, sarcoma, undifferentiated carcinoma, NK cell lymphoma. Immunohistochemically, melanoma, carcinoma, undifferentiated epithelioid sarcoma and also different types of lymphoma were excluded. Therefore, tumors of the histiocytic and dendritic cell lineage had to be considered. Tumors of the dendritic cell lineage were also immunohistochemically excluded, leaving histiocytic sarcoma by exclusion. The patient was followed for six years and six months, with no signs of recurrence of the tumor. Histiocytic sarcomas are tumors of uncertain behavior, with some progressing quickly, and others having a much slower course. As these tumors are rare, there is not much information, although a low number of mitosis might point to a less aggressive course. In the present patient with an unifocal disease, surgical excision was sufficient, without adjuvant radiotherapy and chemotherapy.
| Published in | American Journal of Internal Medicine (Volume 5, Issue 5) |
| DOI | 10.11648/j.ajim.20170505.16 |
| Page(s) | 91-94 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Neoplasms, Histiocytic Sarcoma, Lung, Immunohistochemistry, Surgical Treatment
| [1] | Takahashi E, Nakamura S. Histiocytic sarcoma: an updated literature review based on the 2008 WHO classification. J Clin Exp Hematop 2013; 53 (1): 1-8. |
| [2] | Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol 2004; 28 (9): 1133-44. |
| [3] | Chen CJ, Williams EA, Mc Aneney TE, Williams BJ, Mandell JW, Shaffrey ME. Histiocytic sarcoma of the cavernous sinus: case report and literature review. Brain Tumor Pathol 2015; 32 (1): 66-71. |
| [4] | Sun W, Nordberg ML, Fowler MR. Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. Am J Surg Pathol 2003 Feb; 27 (2): 258-65. |
| [5] | Jang YH, Park CJ, Huh JR, Jang S, Chi HS. A case of histiocytic sarcoma diagnosed by bone marrow biopsy in a patient suffering from fever for 8 months. Korean J Lab Med 2009; 29 (4): 282-5. |
| [6] | Stacher E, Beham-Schmid C, Terpe HJ, Simiantonaki N, Popper HH. Pulmonary histiocytic sarcoma mimicking pulmonary Langerhans cell histiocytosis in a young adult presenting with spontaneous pneumothorax: a potential diagnostic pitfall. Virchows Arch 2009; 455: 187-90. |
| [7] | Tomita S, Ogura G, Inomoto C, et al. Histiocytic sarcoma originating in the lung in a 16-year-old male. J Clin Exp Hematop 2015; 55 (1): 45-9. |
| [8] | Aichaouia C, Daboussi S, Haddaoui A, et al. Unusual lung localization of histiocytic sarcoma. Rev Pneumol Clin 2012; 68 (5): 318-22. |
| [9] | Buonocore S, Valente AL, Nightingale D, Bogart J, Souid AK. Histiocytic sarcoma in a 3-year-old male: a case report. Pediatrics 2005; 116 (2): e322-5. |
| [10] | Schlick K, Aigelsreiter A, Pichler M, et al. Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases. Onkologie 2012; 35 (7-8): 447-50. |
| [11] | Shukla N, Kobos R, Renaud T, et al. Successful treatment of refractory metastatic histiocytic sarcoma with alemtuzumab. Cancer 2012; 118 (15): 3719-24. |
APA Style
Veljko Flego, Helmut Popper, Darian Volaric, Ljiljana Bulat-Kardum. (2017). Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review. American Journal of Internal Medicine, 5(5), 91-94. https://doi.org/10.11648/j.ajim.20170505.16
ACS Style
Veljko Flego; Helmut Popper; Darian Volaric; Ljiljana Bulat-Kardum. Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review. Am. J. Intern. Med. 2017, 5(5), 91-94. doi: 10.11648/j.ajim.20170505.16
AMA Style
Veljko Flego, Helmut Popper, Darian Volaric, Ljiljana Bulat-Kardum. Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review. Am J Intern Med. 2017;5(5):91-94. doi: 10.11648/j.ajim.20170505.16
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajim.20170505.16,
author = {Veljko Flego and Helmut Popper and Darian Volaric and Ljiljana Bulat-Kardum},
title = {Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review},
journal = {American Journal of Internal Medicine},
volume = {5},
number = {5},
pages = {91-94},
doi = {10.11648/j.ajim.20170505.16},
url = {https://doi.org/10.11648/j.ajim.20170505.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170505.16},
abstract = {Pulmonary histiocytic sarcoma is a rare, but highly malignant disease. Its low incidence imposes significant difficulties on physicians confronted with affected patients. The reported patient is a 24-year old male with histiocytic sarcoma of the lung. Left lower lobectomy was performed. Histologically, tumor cells had no features of carcinoma. Several entities were raised as differentials: large B or T cell lymphomas, metastatic melanoma, sarcoma, undifferentiated carcinoma, NK cell lymphoma. Immunohistochemically, melanoma, carcinoma, undifferentiated epithelioid sarcoma and also different types of lymphoma were excluded. Therefore, tumors of the histiocytic and dendritic cell lineage had to be considered. Tumors of the dendritic cell lineage were also immunohistochemically excluded, leaving histiocytic sarcoma by exclusion. The patient was followed for six years and six months, with no signs of recurrence of the tumor. Histiocytic sarcomas are tumors of uncertain behavior, with some progressing quickly, and others having a much slower course. As these tumors are rare, there is not much information, although a low number of mitosis might point to a less aggressive course. In the present patient with an unifocal disease, surgical excision was sufficient, without adjuvant radiotherapy and chemotherapy.},
year = {2017}
}
TY - JOUR T1 - Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review AU - Veljko Flego AU - Helmut Popper AU - Darian Volaric AU - Ljiljana Bulat-Kardum Y1 - 2017/10/24 PY - 2017 N1 - https://doi.org/10.11648/j.ajim.20170505.16 DO - 10.11648/j.ajim.20170505.16 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 91 EP - 94 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20170505.16 AB - Pulmonary histiocytic sarcoma is a rare, but highly malignant disease. Its low incidence imposes significant difficulties on physicians confronted with affected patients. The reported patient is a 24-year old male with histiocytic sarcoma of the lung. Left lower lobectomy was performed. Histologically, tumor cells had no features of carcinoma. Several entities were raised as differentials: large B or T cell lymphomas, metastatic melanoma, sarcoma, undifferentiated carcinoma, NK cell lymphoma. Immunohistochemically, melanoma, carcinoma, undifferentiated epithelioid sarcoma and also different types of lymphoma were excluded. Therefore, tumors of the histiocytic and dendritic cell lineage had to be considered. Tumors of the dendritic cell lineage were also immunohistochemically excluded, leaving histiocytic sarcoma by exclusion. The patient was followed for six years and six months, with no signs of recurrence of the tumor. Histiocytic sarcomas are tumors of uncertain behavior, with some progressing quickly, and others having a much slower course. As these tumors are rare, there is not much information, although a low number of mitosis might point to a less aggressive course. In the present patient with an unifocal disease, surgical excision was sufficient, without adjuvant radiotherapy and chemotherapy. VL - 5 IS - 5 ER -
Information
Email: