American Journal of Internal Medicine

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The Expression and Prognostic Value of NOX4 in Gastric Cancer

Received: 01 August 2018    Accepted: 22 August 2018    Published: 12 October 2018
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Abstract

Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide which threaten the health of human. A lot of work has been done in tumor pathogenesis in recent years, while modest progress in diagnosis and treatment of gastric cancer have been made. Methods: Multiple databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to identify the expression pattern of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), the main source of reactive oxygen species, in gastric cancer. We also analyzed the correlation between the expression level of NOX4 and gastric cancer patients’ clinical features. The prognostic value of NOX4 was explored in TCGA and K-M Plotter. Last, we utilized TCGA and DAVID databases to uncover the underlying molecular mechanisms of NOX4 with TCGA and DAVID databases. Results: We found that NOX4 was upregulated in tumors compared with adjacent non-tumor tissues and overexpression was correlated with tumor invasion and TNM stage in gastric cancer. Furthermore, NOX4 level could be an independent prognostic marker for GC, unacted on the choice of therapy or HER2 expression. Besides, we investigated the potential mechanisms of NOX4 in gastric cancer. Conclusions: Our findings proved that NOX4 may be a new prognostic factor or therapeutic marker for gastric cancer.

DOI 10.11648/j.ajim.20180606.11
Published in American Journal of Internal Medicine (Volume 6, Issue 6, November 2018)
Page(s) 144-151
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

NOX4, Prognostic Values, Gastric Cancer

References
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Author Information
  • Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China

  • Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China

  • Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China

  • Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China

  • Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China

  • Xijing Hospital of Digestive Diseases, Xijing Hospital of the Fourth Military Medical University, Xi'an, China

  • Department of Oncology, Xijing Hospital of the Fourth Military Medical University, Xi'an, China

  • Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China

  • Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China

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  • APA Style

    Lu Qiao, Ning Xie, Yuru Bai, Bin Qin, Baicang Zou, et al. (2018). The Expression and Prognostic Value of NOX4 in Gastric Cancer. American Journal of Internal Medicine, 6(6), 144-151. https://doi.org/10.11648/j.ajim.20180606.11

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    ACS Style

    Lu Qiao; Ning Xie; Yuru Bai; Bin Qin; Baicang Zou, et al. The Expression and Prognostic Value of NOX4 in Gastric Cancer. Am. J. Intern. Med. 2018, 6(6), 144-151. doi: 10.11648/j.ajim.20180606.11

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    AMA Style

    Lu Qiao, Ning Xie, Yuru Bai, Bin Qin, Baicang Zou, et al. The Expression and Prognostic Value of NOX4 in Gastric Cancer. Am J Intern Med. 2018;6(6):144-151. doi: 10.11648/j.ajim.20180606.11

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  • @article{10.11648/j.ajim.20180606.11,
      author = {Lu Qiao and Ning Xie and Yuru Bai and Bin Qin and Baicang Zou and Yongquan Shi and Yan Chen and Na Liu and Jinhai Wang},
      title = {The Expression and Prognostic Value of NOX4 in Gastric Cancer},
      journal = {American Journal of Internal Medicine},
      volume = {6},
      number = {6},
      pages = {144-151},
      doi = {10.11648/j.ajim.20180606.11},
      url = {https://doi.org/10.11648/j.ajim.20180606.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.20180606.11},
      abstract = {Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide which threaten the health of human. A lot of work has been done in tumor pathogenesis in recent years, while modest progress in diagnosis and treatment of gastric cancer have been made. Methods: Multiple databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to identify the expression pattern of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), the main source of reactive oxygen species, in gastric cancer. We also analyzed the correlation between the expression level of NOX4 and gastric cancer patients’ clinical features. The prognostic value of NOX4 was explored in TCGA and K-M Plotter. Last, we utilized TCGA and DAVID databases to uncover the underlying molecular mechanisms of NOX4 with TCGA and DAVID databases. Results: We found that NOX4 was upregulated in tumors compared with adjacent non-tumor tissues and overexpression was correlated with tumor invasion and TNM stage in gastric cancer. Furthermore, NOX4 level could be an independent prognostic marker for GC, unacted on the choice of therapy or HER2 expression. Besides, we investigated the potential mechanisms of NOX4 in gastric cancer. Conclusions: Our findings proved that NOX4 may be a new prognostic factor or therapeutic marker for gastric cancer.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - The Expression and Prognostic Value of NOX4 in Gastric Cancer
    AU  - Lu Qiao
    AU  - Ning Xie
    AU  - Yuru Bai
    AU  - Bin Qin
    AU  - Baicang Zou
    AU  - Yongquan Shi
    AU  - Yan Chen
    AU  - Na Liu
    AU  - Jinhai Wang
    Y1  - 2018/10/12
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ajim.20180606.11
    DO  - 10.11648/j.ajim.20180606.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 144
    EP  - 151
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20180606.11
    AB  - Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide which threaten the health of human. A lot of work has been done in tumor pathogenesis in recent years, while modest progress in diagnosis and treatment of gastric cancer have been made. Methods: Multiple databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to identify the expression pattern of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), the main source of reactive oxygen species, in gastric cancer. We also analyzed the correlation between the expression level of NOX4 and gastric cancer patients’ clinical features. The prognostic value of NOX4 was explored in TCGA and K-M Plotter. Last, we utilized TCGA and DAVID databases to uncover the underlying molecular mechanisms of NOX4 with TCGA and DAVID databases. Results: We found that NOX4 was upregulated in tumors compared with adjacent non-tumor tissues and overexpression was correlated with tumor invasion and TNM stage in gastric cancer. Furthermore, NOX4 level could be an independent prognostic marker for GC, unacted on the choice of therapy or HER2 expression. Besides, we investigated the potential mechanisms of NOX4 in gastric cancer. Conclusions: Our findings proved that NOX4 may be a new prognostic factor or therapeutic marker for gastric cancer.
    VL  - 6
    IS  - 6
    ER  - 

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