Significance of G Test [(1-3)-β-D-Glucan Assay] in the Diagnosis and Guidance of Clinical Medication of Invasive Fungal Infection
American Journal of Internal Medicine
Volume 7, Issue 2, March 2019, Pages: 46-50
Received: Apr. 13, 2019;
Accepted: May 21, 2019;
Published: Jun. 11, 2019
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Lianfang Xue, Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Suishan Qiu, Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Guangchao Yu, Department of Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou, China
Qin-Ai Zhu, Department of Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou, China
Shasha Li, Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Hui Liu, Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Yuping Wang, Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Fengtian Ouyang, College of Pharmacy, Jinan University, Guangzhou, China
Wenyu Gong, Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, China
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Objective: G test [(1-3) -β-D-glucan assay] was a novel texting method for invasive fungal infection (IFI). The study evaluated the diagnostic value of G test for IFI by comparing G test with fungal culture method，and analyze the guiding significance of G test and fungal culture in clinical medication. Methods: 373 inpatients with suspected IFI in the first affiliated hospital of Jinan university from January to December 2017 were retrospectively analyzed. G test and fungal culture results were collected, and their positive rate, sensitivity, specificity, positive and negative predictive values were calculated. The value and rationality of G test for clinical diagnosis of IFI was evaluated by taking the relief and cure of infection symptoms of patients as clinical effective criteria. Results: Among 373 suspected IFI patients, the positive rate of G experiment was 39.95%, higher than that of fungus culture (28.95%, P<0.001). The positive rate of combined G test and fungal culture was 43.70%. To evaluate the consistency of G test with fungal culture method, κ value was 0.596 (P<0.001). When positive fungal culture was used as the criterion for the diagnosis of IFI, the sensitivity, specificity, positive predictive value and negative predictive value of G test for the diagnosis of IFI were 87.04%, 79.25%, 63.09% and 93.75%, respectively. All 373 patients with IFI received antifungal therapy, and the effective rate of the both methods positive group was 72.34%, higher than 42.86% in the only fungal culture positive group (P=0.033) and 30.48% in the both methods negative group (P<0.001). The effective rate of the only G test positive group was 58.18%, higher than that of the both methods negative group (30.48%, P<0.001). There was no significant difference in the therapeutic efficiency between the only G test positive group and the only fungal culture positive group (P=0.303). Conclusion: G test was an effective diagnostic method of IFI, and combined with fungal culture could improve its positive rate and have a higher guiding value for clinical medication.
Invasive Fungal Infection, G Test, (1-3)-β-D-Glucan, Diagnostic Value, Fungal Culture
To cite this article
Significance of G Test [(1-3)-β-D-Glucan Assay] in the Diagnosis and Guidance of Clinical Medication of Invasive Fungal Infection, American Journal of Internal Medicine.
Vol. 7, No. 2,
2019, pp. 46-50.
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
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