Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country

Eric Walter Pefura-Yone; Adamou Dodo Balkissou; Amadou Djenabou; Virginie Poka-Mayap; Christopher Kuaban

doi:doi:10.11648/j.ajim.20190705.14

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Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country

Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Amadou Djenabou, Virginie Poka-Mayap, Christopher Kuaban

Published in American Journal of Internal Medicine (Volume 7, Issue 5)

Received: 8 September 2019 Accepted: 26 September 2019 Published: 11 October 2019

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Abstract

Sleep disorders in patients with atopic dermatitis (AD) are common and can have a negative impact on the quality of life of the affected subjects. Very little data are available on the association between AD and excessive daytime sleepiness (EDS) in adults. The objective of this study was to compare the prevalence of EDS in subjects with AD and those without AD, and to investigate the determinants of EDS in adults with AD. In this cross-sectional population-based study conducted from 2015 to 2018 in Cameroon, adult subjects aged at least 19 years were included by multi-level stratified random sampling. AD was defined as the presence of a chronic itchy dermatitis evolving intermittently over a period of at least 6 months and electively affecting certain areas (fronts of the elbows, back of the knees, front of the ankles, under the buttocks, around the neck, around the eyes or ears) during the last 12 months preceding the survey. EDS was defined by an Epworth score≥10. Logistic regression was used to investigate the independent association between EDS and AD. A difference was considered significant if p<0.05. A total of 8362 subjects (55.2% women) with median age (25th-75th percentiles) of 39 (27-54) years were included. There were 217 subjects (2.6%) with AD and 1022 subjects (12.2%) with EDS. The prevalence of EDS was higher in subjects with AD than in those without AD (22.1% vs. 12%, p<0.001). In multivariate analysis integrating potential confounders (area of recruitment, age, education level, body mass index, association with other allergic diseases), AD remained independently associated with EDS with an adjusted odds ratio (95% CI) of 2.18 (1.54-3.08). No independent associated factors to EDS were found in subjects with AD. There is an independent association between EDS and AD, and nearly one quarter of patients with AD has EDS in this setting. It is necessary to consider the systematic evaluation of EDS in subjects with AD to optimize their management.

Published in	American Journal of Internal Medicine (Volume 7, Issue 5)
DOI	10.11648/j.ajim.20190705.14
Page(s)	127-131
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Atopic Eczema, Dermatitis, Daytime Sleepiness, Sleep Disorders, Africa

References

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APA Style

Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Amadou Djenabou, Virginie Poka-Mayap, Christopher Kuaban. (2019). Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country. American Journal of Internal Medicine, 7(5), 127-131. https://doi.org/10.11648/j.ajim.20190705.14

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ACS Style

Eric Walter Pefura-Yone; Adamou Dodo Balkissou; Amadou Djenabou; Virginie Poka-Mayap; Christopher Kuaban. Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country. Am. J. Intern. Med. 2019, 7(5), 127-131. doi: 10.11648/j.ajim.20190705.14

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AMA Style

Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Amadou Djenabou, Virginie Poka-Mayap, Christopher Kuaban. Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country. Am J Intern Med. 2019;7(5):127-131. doi: 10.11648/j.ajim.20190705.14

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@article{10.11648/j.ajim.20190705.14,
  author = {Eric Walter Pefura-Yone and Adamou Dodo Balkissou and Amadou Djenabou and Virginie Poka-Mayap and Christopher Kuaban},
  title = {Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country},
  journal = {American Journal of Internal Medicine},
  volume = {7},
  number = {5},
  pages = {127-131},
  doi = {10.11648/j.ajim.20190705.14},
  url = {https://doi.org/10.11648/j.ajim.20190705.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20190705.14},
  abstract = {Sleep disorders in patients with atopic dermatitis (AD) are common and can have a negative impact on the quality of life of the affected subjects. Very little data are available on the association between AD and excessive daytime sleepiness (EDS) in adults. The objective of this study was to compare the prevalence of EDS in subjects with AD and those without AD, and to investigate the determinants of EDS in adults with AD. In this cross-sectional population-based study conducted from 2015 to 2018 in Cameroon, adult subjects aged at least 19 years were included by multi-level stratified random sampling. AD was defined as the presence of a chronic itchy dermatitis evolving intermittently over a period of at least 6 months and electively affecting certain areas (fronts of the elbows, back of the knees, front of the ankles, under the buttocks, around the neck, around the eyes or ears) during the last 12 months preceding the survey. EDS was defined by an Epworth score≥10. Logistic regression was used to investigate the independent association between EDS and AD. A difference was considered significant if p<0.05. A total of 8362 subjects (55.2% women) with median age (25th-75th percentiles) of 39 (27-54) years were included. There were 217 subjects (2.6%) with AD and 1022 subjects (12.2%) with EDS. The prevalence of EDS was higher in subjects with AD than in those without AD (22.1% vs. 12%, p<0.001). In multivariate analysis integrating potential confounders (area of recruitment, age, education level, body mass index, association with other allergic diseases), AD remained independently associated with EDS with an adjusted odds ratio (95% CI) of 2.18 (1.54-3.08). No independent associated factors to EDS were found in subjects with AD. There is an independent association between EDS and AD, and nearly one quarter of patients with AD has EDS in this setting. It is necessary to consider the systematic evaluation of EDS in subjects with AD to optimize their management.},
 year = {2019}
}

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TY - JOUR
T1 - Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country
AU - Eric Walter Pefura-Yone
AU - Adamou Dodo Balkissou
AU - Amadou Djenabou
AU - Virginie Poka-Mayap
AU - Christopher Kuaban
Y1 - 2019/10/11
PY - 2019
N1 - https://doi.org/10.11648/j.ajim.20190705.14
DO - 10.11648/j.ajim.20190705.14
T2 - American Journal of Internal Medicine
JF - American Journal of Internal Medicine
JO - American Journal of Internal Medicine
SP - 127
EP - 131
PB - Science Publishing Group
SN - 2330-4324
UR - https://doi.org/10.11648/j.ajim.20190705.14
AB - Sleep disorders in patients with atopic dermatitis (AD) are common and can have a negative impact on the quality of life of the affected subjects. Very little data are available on the association between AD and excessive daytime sleepiness (EDS) in adults. The objective of this study was to compare the prevalence of EDS in subjects with AD and those without AD, and to investigate the determinants of EDS in adults with AD. In this cross-sectional population-based study conducted from 2015 to 2018 in Cameroon, adult subjects aged at least 19 years were included by multi-level stratified random sampling. AD was defined as the presence of a chronic itchy dermatitis evolving intermittently over a period of at least 6 months and electively affecting certain areas (fronts of the elbows, back of the knees, front of the ankles, under the buttocks, around the neck, around the eyes or ears) during the last 12 months preceding the survey. EDS was defined by an Epworth score≥10. Logistic regression was used to investigate the independent association between EDS and AD. A difference was considered significant if p<0.05. A total of 8362 subjects (55.2% women) with median age (25th-75th percentiles) of 39 (27-54) years were included. There were 217 subjects (2.6%) with AD and 1022 subjects (12.2%) with EDS. The prevalence of EDS was higher in subjects with AD than in those without AD (22.1% vs. 12%, p<0.001). In multivariate analysis integrating potential confounders (area of recruitment, age, education level, body mass index, association with other allergic diseases), AD remained independently associated with EDS with an adjusted odds ratio (95% CI) of 2.18 (1.54-3.08). No independent associated factors to EDS were found in subjects with AD. There is an independent association between EDS and AD, and nearly one quarter of patients with AD has EDS in this setting. It is necessary to consider the systematic evaluation of EDS in subjects with AD to optimize their management.
VL - 7
IS - 5
ER -

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Author Information

Eric Walter Pefura-Yone

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon; Pneumology A Service, Yaounde Jamot Hospital, Yaounde, Cameroon
Adamou Dodo Balkissou

Faculty of Medicine and Biomedical Sciences of Garoua, University of Ngaoundéré, Garoua, Cameroon
Amadou Djenabou

Approved Treatment Center for HIV, Yaounde Jamot Hospital, Yaounde, Cameroon
Virginie Poka-Mayap

Approved Treatment Center for HIV, Yaounde Jamot Hospital, Yaounde, Cameroon
Christopher Kuaban

Faculty of Health Sciences, University of Bamenda, Bambili, Cameroon

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APA Style

Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Amadou Djenabou, Virginie Poka-Mayap, Christopher Kuaban. (2019). Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country. American Journal of Internal Medicine, 7(5), 127-131. https://doi.org/10.11648/j.ajim.20190705.14

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ACS Style

Eric Walter Pefura-Yone; Adamou Dodo Balkissou; Amadou Djenabou; Virginie Poka-Mayap; Christopher Kuaban. Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country. Am. J. Intern. Med. 2019, 7(5), 127-131. doi: 10.11648/j.ajim.20190705.14

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AMA Style

Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Amadou Djenabou, Virginie Poka-Mayap, Christopher Kuaban. Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country. Am J Intern Med. 2019;7(5):127-131. doi: 10.11648/j.ajim.20190705.14

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@article{10.11648/j.ajim.20190705.14,
  author = {Eric Walter Pefura-Yone and Adamou Dodo Balkissou and Amadou Djenabou and Virginie Poka-Mayap and Christopher Kuaban},
  title = {Atopic Dermatitis and Excessive Daytime Sleepiness: Analysis of Data from 8362 Adult Subjects in a Sub-Saharan Africa Country},
  journal = {American Journal of Internal Medicine},
  volume = {7},
  number = {5},
  pages = {127-131},
  doi = {10.11648/j.ajim.20190705.14},
  url = {https://doi.org/10.11648/j.ajim.20190705.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20190705.14},
  abstract = {Sleep disorders in patients with atopic dermatitis (AD) are common and can have a negative impact on the quality of life of the affected subjects. Very little data are available on the association between AD and excessive daytime sleepiness (EDS) in adults. The objective of this study was to compare the prevalence of EDS in subjects with AD and those without AD, and to investigate the determinants of EDS in adults with AD. In this cross-sectional population-based study conducted from 2015 to 2018 in Cameroon, adult subjects aged at least 19 years were included by multi-level stratified random sampling. AD was defined as the presence of a chronic itchy dermatitis evolving intermittently over a period of at least 6 months and electively affecting certain areas (fronts of the elbows, back of the knees, front of the ankles, under the buttocks, around the neck, around the eyes or ears) during the last 12 months preceding the survey. EDS was defined by an Epworth score≥10. Logistic regression was used to investigate the independent association between EDS and AD. A difference was considered significant if p<0.05. A total of 8362 subjects (55.2% women) with median age (25th-75th percentiles) of 39 (27-54) years were included. There were 217 subjects (2.6%) with AD and 1022 subjects (12.2%) with EDS. The prevalence of EDS was higher in subjects with AD than in those without AD (22.1% vs. 12%, p<0.001). In multivariate analysis integrating potential confounders (area of recruitment, age, education level, body mass index, association with other allergic diseases), AD remained independently associated with EDS with an adjusted odds ratio (95% CI) of 2.18 (1.54-3.08). No independent associated factors to EDS were found in subjects with AD. There is an independent association between EDS and AD, and nearly one quarter of patients with AD has EDS in this setting. It is necessary to consider the systematic evaluation of EDS in subjects with AD to optimize their management.},
 year = {2019}
}

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