Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review
American Journal of Internal Medicine
Volume 7, Issue 6, November 2019, Pages: 141-146
Received: Aug. 12, 2019;
Accepted: Sep. 6, 2019;
Published: Oct. 24, 2019
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Mónica García-Fernández, Faculty of Medicine, Miguel Hernández University, Elche, Spain
María Dolores Jover-Ríos, Department of Internal Medicine, Hospital La Vega Baja of Orihuela, Alicante, Spain
Pedro Esteve-Atiénzar, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain
Juan Méndez-Mora, Department of English, Marist Brothers High School, Alicante, Spain
Alex Méndez-Jover, Department of English, Marist Brothers High School, Alicante, Spain
Sonia Cascant-Pérez, Primary Medicine, Hospital Francesc Borgia of Gandía, Valencia, Spain
Francisco Caparrós-Hernández, Department of English, Marist Brothers High School, Alicante, Spain
Carmen Seguí-Pérez, Department of English, Marist Brothers High School, Alicante, Spain
Marc Seguí-Pérez, Department of English, Marist Brothers High School, Alicante, Spain
Lidia Ramírez-Utrero, Primary Medicine, University Hospital of San Juan, Alicante, Spain
Carles García-Cervera, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain
Juan Manuel Núñez-Cruz, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain
David Bonet-Tur, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain
Sara Bañón-Escandell, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain
Pablo Roig-Rico, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain; Department of Clinical Medicine, Miguel Hernández University, Elche, Spain
Jorge Peris-García, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain; Department of Clinical Medicine, Miguel Hernández University, Elche, Spain
Asunción Pérez-Fullana, Department of English, Marist Brothers High School, Alicante, Spain
José Miguel Seguí-Ripoll, Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain; Department of Clinical Medicine, Miguel Hernández University, Elche, Spain
In response to the case of a patient with mesenteric panniculitis (MP) and proliferative disease, we reviewed the literature on their possible association and associations with other neoplasms. MP is a non-specific chronic inflammation of the mesenteric fat, with low prevalence and unknown etiology; patients may be asymptomatic or present predominantly gastrointestinal complaints. The disease can be either primary or secondary to other pathologies, including neoplastic ones. Diagnosis is made via computed tomography (CT) and confirmed by biopsy. Currently, there is no established treatment for MP. The literature contains series of variable sample sizes, case reports, reviews of other published studies, and some series after a 5-year follow-up. Papers tend to be relatively consistent when it comes to prevalence data and clinical manifestations. However, there is still controversy regarding the role that secondary MP could play in a paraneoplastic picture. From the diagnostic point of view, the incorporation and use of positron emission tomography (PET), together with CT, has been helpful for the approach and the diagnostic focus in this field. Nevertheless, its usage and the discrimination cut point between inflammatory pathology and tumor pathology (maximum standard uptake value: SUVmax) are not clearly defined in neoplastic cases.
María Dolores Jover-Ríos,
Juan Manuel Núñez-Cruz,
José Miguel Seguí-Ripoll,
Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review, American Journal of Internal Medicine.
Vol. 7, No. 6,
2019, pp. 141-146.
Ayala Gutiérrez MM, Ramón Garrido E. Paniculitis Mesentérica. Revisión. Med Clin (Barc). 2016; 146 (11): 497–505.
Jura V. Sclerosing and retractile mesenteritis. Policlinica. 1924; 31: 575–581.
Ogden WW, 2nd, Bradburn DM, Rives JD. Mesenteric Panniculitis: Review of 27 Cases. Ann Surg. 1965; 161: 864-875.
Scheer F et al. Mesenteric Panniculitis (MP) in CT – A Predictor of Malignancy? Fortschr Röntgenstr. 2016; 188: 926-932.
Mejías Manzano MA et al. Mesenteritis esclerosante relacionada con IgG4, una entidad rara causante de dolor abdominal. Rev Esp Enferm Dig. 2018; 110 (3): 201-203.
Patlas M et al. Cross-Sectional Imaging of Nontraumatic Peritoneal and Mesenteric Emergencies. Canadian Association of Radiologists Journal 2013; 64: 148-153.
Klasen J. et al. Treatment options for spontaneous and postoperative sclerosing mesenteritis. World Journal of Gastrointest Surgery. 2016; 8 (11): 761-765.
He H. et al. Sclerosing Mesenteritis: Multidisciplinary Collaboration Is Essential for Diagnosis and Treatment. Gastroenterol Res. 2017; 10 (1): 50-55.
Gögebakan Ö, Osterhoff MA, Albrecht T. Mesenteric Panniculitis (MP): A Frequent Coincidental CT Finding of Debatable Clinical Significance. Fortschr Röntgenstr 2018; 190: 1044-1052.
Kipfer RE, Moertel CG, Dahlin DC. Mesenteric lipodystrophy. Annals of internal medicine 1974; 80: 582-588.
Daskalogiannaki M, Voloudaki A, Prassopoulos P. et al. CT evaluation of mesenteric panniculitis: prevalence and associated diseases. American journal of roentgenology 2000; 174: 427-431.
Canyigit M, Koksal A, Akgoz A. et al. Multidetector-row computed tomography findings of sclerosing mesenteritis with associated diseases and its prevalence. Japanese journal of radiology 2011; 29: 495-502.
Wilkes A, Griffin N, Dixon L. et al. Mesenteric panniculitis: a paraneoplastic phenomenon? Diseases of the colon and rectum 2012; 55: 806-809.
Cross AJ, McCormick JJ, Griffin N. et al. Malignancy and mesenteric panniculitis. Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland 2016; 18 (4): 372-377.
Halligan S, Plumb A, Taylor S. Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy. Eur Radiol 2016; 26 (12): 4531–4537.
Gogebakan O, Albrecht T, Osterhoff MA. et al. Is mesenteric panniculitis truely a paraneoplastic phenomenon? A matched pair analysis. European journal of radiology 2013; 82: 1853-1859.
Van Putte-Katier N, van Bommel EF, Elgersma OE. et al. Mesenteric panniculitis: prevalence, clinicoradiological presentation and 5-year follow-up. The British journal of radiology 2014; 87 (1044): 20140451.
Protin-Catteau L, Thiefin G, Barbe C. et al. Mesenteric panniculitis: review of consecutive abdominal MDCT examinations with a matched-pair analysis. Acta radiologica 2016; 57: 1438-1444.
Khasminsky V, Ram E, Atar E. et al. Is there an association between mesenteric panniculitis and lymphoma? A case control analysis. Clin Radiol 2017; 72 (10): 844-849.
Coulier B. Mesenteric panniculitis. Part 2: prevalence and natural course: MDCT prospective study. JBR-BTR: organe de la Societe royale belge de radiologie 2011; 94: 241-246.
Orcajo Rincón, J., Rotger Regi, A., Mari Hualde, A., Reguera Berenguer, L., Hernandez Moreno, L. y Alonso Farto, J. A prospective study to determine the real value of mesenteric 18F-FDG uptake in cancer patients. inflammatory or tumoral mesenteric paniculitis? Rev Esp Med Nucl Imagen Mol. 2014; 33 (6): 352-357.
Zissin R, Metser U, Hain D, Even-Sapir E. Mesenteric panniculitis in oncologic patients: PET-CT findings. Br J Radiol. 2006; 79: 37-43.
Ehrenpreis E, Rao AS, Aki R, Brown H, Pae T, Boiskin I. Normal positron emission tomography-computerized tomogram in a patient with apparent mesenteric panniculitis: biopsy is still the answer. Case Rep Gastroenterol. 2009; 3: 131-7.
M. Mella-Laborde, F. Ivorra-Muñoz, S. García-García, J. M. Seguí-Ripoll, A. Compañ-Rosique. Paniculitis mesentérica como manifestación inicial de un linfoma de células B. Acta Gastroenterol Latinoam 2015: 45 (2) 001-002.