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The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy
American Journal of Internal Medicine
Volume 8, Issue 5, September 2020, Pages: 197-203
Received: Jul. 7, 2020; Accepted: Jul. 22, 2020; Published: Aug. 13, 2020
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Victoria Serhiyenko, Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Marta Hotsko, Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Alexandr Serhiyenko, Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Oksana Snitynska, Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Ludmila Serhiyenko, Department of Medical Biology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Volodymyr Segin, Lviv Regional State Clinical Treatment and Diagnostic Endocrinology Center, Lviv, Ukraine
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Development of chronic complications in type 2 diabetes mellitus (T2DM), namely cardiac automonic neuropathy (CAN), had been implicated as an independent risk factor for cardiovascular mortality. This paper presents the results obtained during the study of possible alpha-lipoic acid (ALA) impact on the state of insulin resistance (IR), the content of some pro- and anti-inflammatory factors in patients with T2DM and definite stage of CAN. Our study involved 33 persons with diagnosed T2DM and definite CAN, which were allocated to one of two groups. The control group (15 patients) received standard hypoglycemic treatment, whereas the intervention group (18 patients) received ALA 600 mg in film-coated tablets/q.d. in addition to standard therapy. Treatment period was 3 months in duration. Levels of glycated hemoglobin A1c, glucose, immunoreactive insulin (IRI), leptin, interleukin (IL) IL-6 and IL-8, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) in the blood were measured. TNF-alpha/IL-10 ratio and Homeostasis model assessment IR (HOMA-IR) were calculated. The significant reduction in glucose, IRI, leptin concentration and HOMA-IR parameters; decrease in the pro-inflammatory link activity, namely hs-CRP, TNF-alpha, IL-6 and IL-8 levels, TNF-alpha/IL-10 ratio, with no changes in IL-10 content after 3 months of treatment was found. The results of our study demonstrated the decrease in the pro-inflammatory link activity after treatment and allow us to consider ALA as one of the promising drug for complex treatment of definite stage of CAN in patients with T2DM.
Diabetic Cardiac Autonomic Neuropathy, Alpha-Lipoic Acid, Inflammation, Type 2 Diabetes Mellitus
To cite this article
Victoria Serhiyenko, Marta Hotsko, Alexandr Serhiyenko, Oksana Snitynska, Ludmila Serhiyenko, Volodymyr Segin, The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy, American Journal of Internal Medicine. Vol. 8, No. 5, 2020, pp. 197-203. doi: 10.11648/j.ajim.20200805.11
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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