American Journal of Internal Medicine

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Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy

Received: 24 October 2015    Accepted: 26 October 2015    Published: 30 November 2015
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Abstract

Background: Diabetic nephropathy has become the leading cause of end-stage renal failure in Europe, the United States and Japan (25-44%). Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. The aim of the present work is to estimate serum chemerin level and to correlate its level in the patients with the stage of the diabetic nephropathy disease. Patients and Methods: The present study included 60 subjects who were divided into 4 groups Group I: included 15 diabetic patients with norm albuminuria Group II: included 15 diabetic patients with microalbuminuria Group III: included 15 diabetic patients with macroalbuminuria Group IV: included 15 normal subjects as a control group. All patients and controls were subjected to estimation of body mass index. Blood urea, serum creatinine and estimated GFR, Urinary albumin to urinary creatinine ratio, complete lipid profile (LDL, HDL, TG) and Serum chemerin level by ELIZA. Results: Serum chemerin level was higher in diabetic than non-diabetic persons and was higher in patients with macroalbuminuria than those with normo and microalbuminuria and its level is correlated with markers of impaired renal function. Conclusion: chemerin could have a role in progression of diabetic nephropathy or its level could be elevated due to impaired renal excretion which should be further investigated.

DOI 10.11648/j.ajim.s.2016040201.13
Published in American Journal of Internal Medicine (Volume 4, Issue 2-1, March 2016)

This article belongs to the Special Issue Different Medical Research From Middle East

Page(s) 13-17
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetic Nephropathy, Chemerin, Albuminuria

References
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[5] Ballard DJ, Humphery LL, Melton LJ III. Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. Diabetes 1988; 37: 405-12.
[6] Ernst MC, Sinal CJ. Chemerin at the cross roads of inflammation and obesity. Trends Endocrinol Metab 2010; 21: 660– 7.
[7] Sell H, Divoux A, Poitou C, Basdevant A, Bouillot JL, Bedossa P, et al. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J Clin Endocrinol Metab 2010; 95: 2892– 6.
[8] Lehrke M, Becker A, Greif M, Stark R, Laubender R, Ziegler F et al. Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis. Eur J Endocrinol 2009; 161: 339–44.
[9] Sell H, Laurencikiene J, Taube A. Chemerin is a novel adipoctye derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 2009; 58: 2731– 40.
[10] Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, et al. “Chemerin is a novel adipokine associated with obesity and metabolic syndrome”. Endocrinol 2007; 148: 4687–94.
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[18] Saraheimo M, Forsblom C, Thorn L, Wade´n J, Rosenga°rd- Ba¨rlund M, Heikkila¨ O, et al. Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes. Diabetes Care 2008; 31: 1165–9.
[19] Murata M, Saito T, Otani T, Sasaki M, Ikoma A, Toyoshima H, et al. An increase in serum retinol-binding protein 4 in the type 2 diabetic subjects with nephropathy. Endocr J 2009; 56: 287–94.
[20] Pfau D, Bachmann A, Lo¨ ssner U, Kratzsch J, Blu¨ her M, Stumvoll M, et al. Serum levels of the adipokine chemerin in relation to renal function. Diabetes Care 2010; 33: 171–3.
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Author Information
  • Departments of Internal Medicine, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

  • Departments of Internal Medicine, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

  • Clinical Pathology Department, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

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    Iman E. El-Gohary, Azza Abedl-Karim, Doaa I. Hashad. (2015). Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy. American Journal of Internal Medicine, 4(2-1), 13-17. https://doi.org/10.11648/j.ajim.s.2016040201.13

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    ACS Style

    Iman E. El-Gohary; Azza Abedl-Karim; Doaa I. Hashad. Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy. Am. J. Intern. Med. 2015, 4(2-1), 13-17. doi: 10.11648/j.ajim.s.2016040201.13

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    AMA Style

    Iman E. El-Gohary, Azza Abedl-Karim, Doaa I. Hashad. Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy. Am J Intern Med. 2015;4(2-1):13-17. doi: 10.11648/j.ajim.s.2016040201.13

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  • @article{10.11648/j.ajim.s.2016040201.13,
      author = {Iman E. El-Gohary and Azza Abedl-Karim and Doaa I. Hashad},
      title = {Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy},
      journal = {American Journal of Internal Medicine},
      volume = {4},
      number = {2-1},
      pages = {13-17},
      doi = {10.11648/j.ajim.s.2016040201.13},
      url = {https://doi.org/10.11648/j.ajim.s.2016040201.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.s.2016040201.13},
      abstract = {Background: Diabetic nephropathy has become the leading cause of end-stage renal failure in Europe, the United States and Japan (25-44%). Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. The aim of the present work is to estimate serum chemerin level and to correlate its level in the patients with the stage of the diabetic nephropathy disease. Patients and Methods: The present study included 60 subjects who were divided into 4 groups Group I: included 15 diabetic patients with norm albuminuria Group II: included 15 diabetic patients with microalbuminuria Group III: included 15 diabetic patients with macroalbuminuria Group IV: included 15 normal subjects as a control group. All patients and controls were subjected to estimation of body mass index. Blood urea, serum creatinine and estimated GFR, Urinary albumin to urinary creatinine ratio, complete lipid profile (LDL, HDL, TG) and Serum chemerin level by ELIZA. Results: Serum chemerin level was higher in diabetic than non-diabetic persons and was higher in patients with macroalbuminuria than those with normo and microalbuminuria and its level is correlated with markers of impaired renal function. Conclusion: chemerin could have a role in progression of diabetic nephropathy or its level could be elevated due to impaired renal excretion which should be further investigated.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy
    AU  - Iman E. El-Gohary
    AU  - Azza Abedl-Karim
    AU  - Doaa I. Hashad
    Y1  - 2015/11/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajim.s.2016040201.13
    DO  - 10.11648/j.ajim.s.2016040201.13
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 13
    EP  - 17
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.s.2016040201.13
    AB  - Background: Diabetic nephropathy has become the leading cause of end-stage renal failure in Europe, the United States and Japan (25-44%). Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. The aim of the present work is to estimate serum chemerin level and to correlate its level in the patients with the stage of the diabetic nephropathy disease. Patients and Methods: The present study included 60 subjects who were divided into 4 groups Group I: included 15 diabetic patients with norm albuminuria Group II: included 15 diabetic patients with microalbuminuria Group III: included 15 diabetic patients with macroalbuminuria Group IV: included 15 normal subjects as a control group. All patients and controls were subjected to estimation of body mass index. Blood urea, serum creatinine and estimated GFR, Urinary albumin to urinary creatinine ratio, complete lipid profile (LDL, HDL, TG) and Serum chemerin level by ELIZA. Results: Serum chemerin level was higher in diabetic than non-diabetic persons and was higher in patients with macroalbuminuria than those with normo and microalbuminuria and its level is correlated with markers of impaired renal function. Conclusion: chemerin could have a role in progression of diabetic nephropathy or its level could be elevated due to impaired renal excretion which should be further investigated.
    VL  - 4
    IS  - 2-1
    ER  - 

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