American Journal of Internal Medicine

| Peer-Reviewed |

Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes

Received: 31 May 2015    Accepted: 09 June 2015    Published: 25 June 2015
Views:       Downloads:

Share This Article

Abstract

Background: Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours (2-hr) after breakfast (ABF) plasma glucose, are often used to monitor and manage glycemia in stable diabetic patients. Data regarding the relationship and relative contribution of FPG and 2-hr ABF plasma glucose to HbA1c level in Type 2 diabetes mellitus (T2DM) are insufficient. Objective: To examine the correlation of FPG, and 2-hr ABF with HbA1c in known patients having T2DM; and to find out which one of FPG and ABF is the dominant contributor to overall glycemia in monitoring diabetes. Study Design and Methods: The study was carried on 664 known T2DM patients under treatment and routine follow-up at a tertiary care hospital in Bangladesh. FPG & 2-hr ABF plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography based hemoglobin assay system. The Pearson correlation coefficient was used to investigate the relationship of FPG and ABF with HbA1c and their significance. Results: Both FPG and ABF levels were correlated with HbA1c but higher correlation was seen between FPG and HbA1c. The correlation coefficients between FPG and HbA1c and between ABF and HbA1c were 0.722 and 0.664 respectively. Both the correlations were found statistically significant (p<0.001). Conclusion: In patients with T2DM, FPG and ABF both were significantly correlated with HbA1c; and in our study we found that overall correlation of HbA1c with FPG was higher than ABF plasma glucose level.

DOI 10.11648/j.ajim.20150304.13
Published in American Journal of Internal Medicine (Volume 3, Issue 4, July 2015)
Page(s) 160-164
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Glycosylated Hemoglobin, Fasting Plasma Glucose, 2 Hours After Breakfast, Diabetes Mellitus

References
[1] Whiting DR, Guariguata L, Weil C, Shaw J. IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011 (Dec);94(3):311-21.
[2] Service FJ, O’Brien PC. The relation of glycaemia to the risk of development and progression of retinopathy in the Diabetic Control and Complications Trial. Diabetologia 2001;44(10):1215-20.
[3] Sorkin JD, Muller DC, Fleg JL, Andres R. The relation of fasting and 2-h postchallenge plasma glucose to mortality: data from the Baltimore Longitudinal Study of Aging with a critical review of the literature. Diabetes Care 2005;28:2626-32.
[4] Cavalot F, Pagliarino A, Valle M, Martino LD, Bonomo K, Massucco P, et al. Postprandial blood glucose predicts cardiovascular events and all-cause mortality in type 2 diabetes in a 14-year follow-up: lessons from the San Luigi Gonzaga Diabetes Study. Diabetes Care 2011;34:2237-43.
[5] Albers JW, Herman WH, Pop-Busui R, Feldman EL, Martin CL, Cleary PA, et al. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) study. Diabetes Care 2010;33:1090–96.
[6] Stratton IM, Adler AI, Neil HAW, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405–12.
[7] Handelsman Y, Mechanick JI, Blonde L, Grunberger G, Bloomgarden ZT, Bray GA,, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan. Endocr Pract 2011;17(Suppl 2):1-53
[8] Diabetes Control and Complications Trial Research Group, ‘The effect of intensive treatment of diabetes on development and progression of long term complications in insulin dependent diabetes mellitus’, N Engl J Med 1993;329:977-86.
[9] UK Prospective Diabetes Study Group, Intensive blood glucose with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998;352:837-53.
[10] Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS et al. National Academy of Clinical Biochemistry. Position statement executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care 2011;34:1419–23.
[11] Bonora E, Calcaterra F, Lombardi S, Bonfante N, Formentini G, Bonadonna RC, et al. Plasma glucose levels throughout the day and HbA1C interrelationships control in type 2 diabetes: implications for treatment and monitoring of metabolic control. Diabetes Care 2001 Dec;24(12):2023-29.
[12] Saiedullah M, Begum S, Shermin S, Rahman MR, Khan MAH. Relationship of glycosylated hemoglobin with fasting and postprandial plasma glucose in nondiabetic, pre-diabetic and newly diagnosed diabetic subjects. Bangladesh Med J 2011;40:37-38.
[13] Hossain T, Latif ZA, Sarkar AA. Relationship of HbA1c with Fasting and Plasma Glucose 2 Hours after Oral Glucose Load in Non Diabetic and Newly Diagnosed Pre Diabetic and Diabetic Patients. Birdem Med J 2012;2(2):81-83.
[14] Gupta S, Puppalwar PV, Chalak A. Correlation of fasting and post meal plasma glucose level to increased HbA1c levels in type-2 diabetes mellitus. Int J Adv Med 2014;1:127-31.
[15] Carroll M, Izard A, Riboni K, Burge M, Schade D: Fasting hyperglycemia predicts the magnitude of postprandial hyperglycemia. Diabetes Care 2002;25:1247–48.
[16] Masram SW, Bimanpalli MV. Assessment of contribution of fasting and post meal plasma glucose to increased HbA1C in diabetes mellitus-comparative study. Int J Biol Med Res 2012;3(3):2020-24.
[17] Azim W, Mushtaq GM, Azim S, Farooq W. Assessment of fasting and two-hour post-prandial glucose as an economical test for monitoring of glycemic control, compared to glycated haemoglobin. Med Channel 2011;17(2):5-7.
[18] Shahram H, Ghazaleh N. Relation of fasting and postprandial plasma glucose with hemoglobinA1c in diabetics. Int J Diabetes Dev Ctries 2010 Jan-Mar;30(1):8–10.
[19] Rosediani M, Azidah AK, Mafauzy M. Correlation between fasting plasma glucose, post prandial glucose and glycated haemoglobin and fructosamine. Med J Malaysia 2006 Mar;61(1):67-71.
[20] Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA1c. Diabetes Care 2003;26:881–85.
[21] Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002;48(3):436-72.
[22] American Diabetes Association: Postprandial blood glucose (Consensus Statement). Diabetes Care 2001;24:775-78.
Author Information
  • Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, No. 3, Jalan Greentown, Ipoh, Perak, Malaysia

  • Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, No. 3, Jalan Greentown, Ipoh, Perak, Malaysia

  • Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh

  • Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh

  • Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh

  • Department of Internal Medicine (Cardiology), Gastro Liver Hospital & Research Institute Ltd, Dhaka, Bangladesh

  • Department of Biochemistry, Shahid Syed Nazrul Islam Medical College, Kishoreganj, Bangladesh

Cite This Article
  • APA Style

    Sheikh Salahuddin Ahmed, Tarafdar Runa Laila, Fazle Nur, Mamun Ul Islam Khan, Umme Sadia Mili, et al. (2015). Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes. American Journal of Internal Medicine, 3(4), 160-164. https://doi.org/10.11648/j.ajim.20150304.13

    Copy | Download

    ACS Style

    Sheikh Salahuddin Ahmed; Tarafdar Runa Laila; Fazle Nur; Mamun Ul Islam Khan; Umme Sadia Mili, et al. Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes. Am. J. Intern. Med. 2015, 3(4), 160-164. doi: 10.11648/j.ajim.20150304.13

    Copy | Download

    AMA Style

    Sheikh Salahuddin Ahmed, Tarafdar Runa Laila, Fazle Nur, Mamun Ul Islam Khan, Umme Sadia Mili, et al. Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes. Am J Intern Med. 2015;3(4):160-164. doi: 10.11648/j.ajim.20150304.13

    Copy | Download

  • @article{10.11648/j.ajim.20150304.13,
      author = {Sheikh Salahuddin Ahmed and Tarafdar Runa Laila and Fazle Nur and Mamun Ul Islam Khan and Umme Sadia Mili and Md. Abdul Mahid Khan and Mohammad Rafiqul Hoque},
      title = {Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes},
      journal = {American Journal of Internal Medicine},
      volume = {3},
      number = {4},
      pages = {160-164},
      doi = {10.11648/j.ajim.20150304.13},
      url = {https://doi.org/10.11648/j.ajim.20150304.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.20150304.13},
      abstract = {Background: Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours (2-hr) after breakfast (ABF) plasma glucose, are often used to monitor and manage glycemia in stable diabetic patients. Data regarding the relationship and relative contribution of FPG and 2-hr ABF plasma glucose to HbA1c level in Type 2 diabetes mellitus (T2DM) are insufficient. Objective: To examine the correlation of FPG, and 2-hr ABF with HbA1c in known patients having T2DM; and to find out which one of FPG and ABF is the dominant contributor to overall glycemia in monitoring diabetes. Study Design and Methods: The study was carried on 664 known T2DM patients under treatment and routine follow-up at a tertiary care hospital in Bangladesh. FPG & 2-hr ABF plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography based hemoglobin assay system. The Pearson correlation coefficient was used to investigate the relationship of FPG and ABF with HbA1c and their significance. Results: Both FPG and ABF levels were correlated with HbA1c but higher correlation was seen between FPG and HbA1c. The correlation coefficients between FPG and HbA1c and between ABF and HbA1c were 0.722 and 0.664 respectively. Both the correlations were found statistically significant (p<0.001). Conclusion: In patients with T2DM, FPG and ABF both were significantly correlated with HbA1c; and in our study we found that overall correlation of HbA1c with FPG was higher than ABF plasma glucose level.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes
    AU  - Sheikh Salahuddin Ahmed
    AU  - Tarafdar Runa Laila
    AU  - Fazle Nur
    AU  - Mamun Ul Islam Khan
    AU  - Umme Sadia Mili
    AU  - Md. Abdul Mahid Khan
    AU  - Mohammad Rafiqul Hoque
    Y1  - 2015/06/25
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajim.20150304.13
    DO  - 10.11648/j.ajim.20150304.13
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 160
    EP  - 164
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20150304.13
    AB  - Background: Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours (2-hr) after breakfast (ABF) plasma glucose, are often used to monitor and manage glycemia in stable diabetic patients. Data regarding the relationship and relative contribution of FPG and 2-hr ABF plasma glucose to HbA1c level in Type 2 diabetes mellitus (T2DM) are insufficient. Objective: To examine the correlation of FPG, and 2-hr ABF with HbA1c in known patients having T2DM; and to find out which one of FPG and ABF is the dominant contributor to overall glycemia in monitoring diabetes. Study Design and Methods: The study was carried on 664 known T2DM patients under treatment and routine follow-up at a tertiary care hospital in Bangladesh. FPG & 2-hr ABF plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography based hemoglobin assay system. The Pearson correlation coefficient was used to investigate the relationship of FPG and ABF with HbA1c and their significance. Results: Both FPG and ABF levels were correlated with HbA1c but higher correlation was seen between FPG and HbA1c. The correlation coefficients between FPG and HbA1c and between ABF and HbA1c were 0.722 and 0.664 respectively. Both the correlations were found statistically significant (p<0.001). Conclusion: In patients with T2DM, FPG and ABF both were significantly correlated with HbA1c; and in our study we found that overall correlation of HbA1c with FPG was higher than ABF plasma glucose level.
    VL  - 3
    IS  - 4
    ER  - 

    Copy | Download

  • Sections