Sex differences were reported in Irritable Bowel Syndrome. We aimed to demonstrate the effect of gonadal hormones on colonic contractile activity. In this study, we performed in vitro measurements of colonic contractile activity in longitudinal smooth muscle strips of female and male Albino rats. After administration of a gonadal hormone (estrogen (EST), progesterone (PROG) and testosterone (TEST)) or ethanol (ETH) solution as control, stimulation with acetylcholine (ACh) or inhibition with norepinephrine (NE) was performed. We found that increasing doses of EST resulted in a stepwise inhibition of SCCA in both sexes and inhibited the ACh effect in females. Similarly, high dose PROG inhibited SCCA in females. TEST inhibited SCCA in males but not Ach induced contractions. TEST reduced the inhibitory effect of NE in female rats. In conclusion, exposure of colonic smooth muscle strips to gonadal hormones led to sex-dependent changes in SCCA and modified the response of smooth muscle strips to both pro-contractile and anti-contractile neurotransmitters.
| Published in | American Journal of Internal Medicine (Volume 5, Issue 2) |
| DOI | 10.11648/j.ajim.20170502.13 |
| Page(s) | 26-36 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Colonic Smooth Muscle, Estrogen, Bowel Disorders, Gonadal Hormones, Irritable Bowel Syndrome, Motility
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APA Style
Mohamad Yosof Rezk. (2017). Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats. American Journal of Internal Medicine, 5(2), 26-36. https://doi.org/10.11648/j.ajim.20170502.13
ACS Style
Mohamad Yosof Rezk. Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats. Am. J. Intern. Med. 2017, 5(2), 26-36. doi: 10.11648/j.ajim.20170502.13
AMA Style
Mohamad Yosof Rezk. Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats. Am J Intern Med. 2017;5(2):26-36. doi: 10.11648/j.ajim.20170502.13
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Download@article{10.11648/j.ajim.20170502.13,
author = {Mohamad Yosof Rezk},
title = {Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats},
journal = {American Journal of Internal Medicine},
volume = {5},
number = {2},
pages = {26-36},
doi = {10.11648/j.ajim.20170502.13},
url = {https://doi.org/10.11648/j.ajim.20170502.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170502.13},
abstract = {Sex differences were reported in Irritable Bowel Syndrome. We aimed to demonstrate the effect of gonadal hormones on colonic contractile activity. In this study, we performed in vitro measurements of colonic contractile activity in longitudinal smooth muscle strips of female and male Albino rats. After administration of a gonadal hormone (estrogen (EST), progesterone (PROG) and testosterone (TEST)) or ethanol (ETH) solution as control, stimulation with acetylcholine (ACh) or inhibition with norepinephrine (NE) was performed. We found that increasing doses of EST resulted in a stepwise inhibition of SCCA in both sexes and inhibited the ACh effect in females. Similarly, high dose PROG inhibited SCCA in females. TEST inhibited SCCA in males but not Ach induced contractions. TEST reduced the inhibitory effect of NE in female rats. In conclusion, exposure of colonic smooth muscle strips to gonadal hormones led to sex-dependent changes in SCCA and modified the response of smooth muscle strips to both pro-contractile and anti-contractile neurotransmitters.},
year = {2017}
}
TY - JOUR T1 - Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats AU - Mohamad Yosof Rezk Y1 - 2017/04/17 PY - 2017 N1 - https://doi.org/10.11648/j.ajim.20170502.13 DO - 10.11648/j.ajim.20170502.13 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 26 EP - 36 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20170502.13 AB - Sex differences were reported in Irritable Bowel Syndrome. We aimed to demonstrate the effect of gonadal hormones on colonic contractile activity. In this study, we performed in vitro measurements of colonic contractile activity in longitudinal smooth muscle strips of female and male Albino rats. After administration of a gonadal hormone (estrogen (EST), progesterone (PROG) and testosterone (TEST)) or ethanol (ETH) solution as control, stimulation with acetylcholine (ACh) or inhibition with norepinephrine (NE) was performed. We found that increasing doses of EST resulted in a stepwise inhibition of SCCA in both sexes and inhibited the ACh effect in females. Similarly, high dose PROG inhibited SCCA in females. TEST inhibited SCCA in males but not Ach induced contractions. TEST reduced the inhibitory effect of NE in female rats. In conclusion, exposure of colonic smooth muscle strips to gonadal hormones led to sex-dependent changes in SCCA and modified the response of smooth muscle strips to both pro-contractile and anti-contractile neurotransmitters. VL - 5 IS - 2 ER -
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