The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy

Victoria Serhiyenko; Marta Hotsko; Alexandr Serhiyenko; Oksana Snitynska; Ludmila Serhiyenko; Volodymyr Segin

doi:doi:10.11648/j.ajim.20200805.11

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The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy

Victoria Serhiyenko, Marta Hotsko, Alexandr Serhiyenko, Oksana Snitynska, Ludmila Serhiyenko, Volodymyr Segin

Published in American Journal of Internal Medicine (Volume 8, Issue 5)

Received: 7 July 2020 Accepted: 22 July 2020 Published: 13 August 2020

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Abstract

Development of chronic complications in type 2 diabetes mellitus (T2DM), namely cardiac automonic neuropathy (CAN), had been implicated as an independent risk factor for cardiovascular mortality. This paper presents the results obtained during the study of possible alpha-lipoic acid (ALA) impact on the state of insulin resistance (IR), the content of some pro- and anti-inflammatory factors in patients with T2DM and definite stage of CAN. Our study involved 33 persons with diagnosed T2DM and definite CAN, which were allocated to one of two groups. The control group (15 patients) received standard hypoglycemic treatment, whereas the intervention group (18 patients) received ALA 600 mg in film-coated tablets/q.d. in addition to standard therapy. Treatment period was 3 months in duration. Levels of glycated hemoglobin A1c, glucose, immunoreactive insulin (IRI), leptin, interleukin (IL) IL-6 and IL-8, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) in the blood were measured. TNF-alpha/IL-10 ratio and Homeostasis model assessment IR (HOMA-IR) were calculated. The significant reduction in glucose, IRI, leptin concentration and HOMA-IR parameters; decrease in the pro-inflammatory link activity, namely hs-CRP, TNF-alpha, IL-6 and IL-8 levels, TNF-alpha/IL-10 ratio, with no changes in IL-10 content after 3 months of treatment was found. The results of our study demonstrated the decrease in the pro-inflammatory link activity after treatment and allow us to consider ALA as one of the promising drug for complex treatment of definite stage of CAN in patients with T2DM.

Published in	American Journal of Internal Medicine (Volume 8, Issue 5)
DOI	10.11648/j.ajim.20200805.11
Page(s)	197-203
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetic Cardiac Autonomic Neuropathy, Alpha-Lipoic Acid, Inflammation, Type 2 Diabetes Mellitus

References

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APA Style

Victoria Serhiyenko, Marta Hotsko, Alexandr Serhiyenko, Oksana Snitynska, Ludmila Serhiyenko, et al. (2020). The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy. American Journal of Internal Medicine, 8(5), 197-203. https://doi.org/10.11648/j.ajim.20200805.11

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ACS Style

Victoria Serhiyenko; Marta Hotsko; Alexandr Serhiyenko; Oksana Snitynska; Ludmila Serhiyenko, et al. The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy. Am. J. Intern. Med. 2020, 8(5), 197-203. doi: 10.11648/j.ajim.20200805.11

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AMA Style

Victoria Serhiyenko, Marta Hotsko, Alexandr Serhiyenko, Oksana Snitynska, Ludmila Serhiyenko, et al. The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy. Am J Intern Med. 2020;8(5):197-203. doi: 10.11648/j.ajim.20200805.11

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@article{10.11648/j.ajim.20200805.11,
  author = {Victoria Serhiyenko and Marta Hotsko and Alexandr Serhiyenko and Oksana Snitynska and Ludmila Serhiyenko and Volodymyr Segin},
  title = {The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {5},
  pages = {197-203},
  doi = {10.11648/j.ajim.20200805.11},
  url = {https://doi.org/10.11648/j.ajim.20200805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200805.11},
  abstract = {Development of chronic complications in type 2 diabetes mellitus (T2DM), namely cardiac automonic neuropathy (CAN), had been implicated as an independent risk factor for cardiovascular mortality. This paper presents the results obtained during the study of possible alpha-lipoic acid (ALA) impact on the state of insulin resistance (IR), the content of some pro- and anti-inflammatory factors in patients with T2DM and definite stage of CAN. Our study involved 33 persons with diagnosed T2DM and definite CAN, which were allocated to one of two groups. The control group (15 patients) received standard hypoglycemic treatment, whereas the intervention group (18 patients) received ALA 600 mg in film-coated tablets/q.d. in addition to standard therapy. Treatment period was 3 months in duration. Levels of glycated hemoglobin A1c, glucose, immunoreactive insulin (IRI), leptin, interleukin (IL) IL-6 and IL-8, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) in the blood were measured. TNF-alpha/IL-10 ratio and Homeostasis model assessment IR (HOMA-IR) were calculated. The significant reduction in glucose, IRI, leptin concentration and HOMA-IR parameters; decrease in the pro-inflammatory link activity, namely hs-CRP, TNF-alpha, IL-6 and IL-8 levels, TNF-alpha/IL-10 ratio, with no changes in IL-10 content after 3 months of treatment was found. The results of our study demonstrated the decrease in the pro-inflammatory link activity after treatment and allow us to consider ALA as one of the promising drug for complex treatment of definite stage of CAN in patients with T2DM.},
 year = {2020}
}

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TY  - JOUR
T1  - The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy
AU  - Victoria Serhiyenko
AU  - Marta Hotsko
AU  - Alexandr Serhiyenko
AU  - Oksana Snitynska
AU  - Ludmila Serhiyenko
AU  - Volodymyr Segin
Y1  - 2020/08/13
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200805.11
DO  - 10.11648/j.ajim.20200805.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 197
EP  - 203
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200805.11
AB  - Development of chronic complications in type 2 diabetes mellitus (T2DM), namely cardiac automonic neuropathy (CAN), had been implicated as an independent risk factor for cardiovascular mortality. This paper presents the results obtained during the study of possible alpha-lipoic acid (ALA) impact on the state of insulin resistance (IR), the content of some pro- and anti-inflammatory factors in patients with T2DM and definite stage of CAN. Our study involved 33 persons with diagnosed T2DM and definite CAN, which were allocated to one of two groups. The control group (15 patients) received standard hypoglycemic treatment, whereas the intervention group (18 patients) received ALA 600 mg in film-coated tablets/q.d. in addition to standard therapy. Treatment period was 3 months in duration. Levels of glycated hemoglobin A1c, glucose, immunoreactive insulin (IRI), leptin, interleukin (IL) IL-6 and IL-8, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) in the blood were measured. TNF-alpha/IL-10 ratio and Homeostasis model assessment IR (HOMA-IR) were calculated. The significant reduction in glucose, IRI, leptin concentration and HOMA-IR parameters; decrease in the pro-inflammatory link activity, namely hs-CRP, TNF-alpha, IL-6 and IL-8 levels, TNF-alpha/IL-10 ratio, with no changes in IL-10 content after 3 months of treatment was found. The results of our study demonstrated the decrease in the pro-inflammatory link activity after treatment and allow us to consider ALA as one of the promising drug for complex treatment of definite stage of CAN in patients with T2DM.
VL  - 8
IS  - 5
ER  -

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Author Information

Victoria Serhiyenko

Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Marta Hotsko

Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Alexandr Serhiyenko

Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Oksana Snitynska

Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Ludmila Serhiyenko

Department of Medical Biology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Volodymyr Segin

Lviv Regional State Clinical Treatment and Diagnostic Endocrinology Center, Lviv, Ukraine

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APA Style

Victoria Serhiyenko, Marta Hotsko, Alexandr Serhiyenko, Oksana Snitynska, Ludmila Serhiyenko, et al. (2020). The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy. American Journal of Internal Medicine, 8(5), 197-203. https://doi.org/10.11648/j.ajim.20200805.11

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ACS Style

Victoria Serhiyenko; Marta Hotsko; Alexandr Serhiyenko; Oksana Snitynska; Ludmila Serhiyenko, et al. The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy. Am. J. Intern. Med. 2020, 8(5), 197-203. doi: 10.11648/j.ajim.20200805.11

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AMA Style

Victoria Serhiyenko, Marta Hotsko, Alexandr Serhiyenko, Oksana Snitynska, Ludmila Serhiyenko, et al. The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy. Am J Intern Med. 2020;8(5):197-203. doi: 10.11648/j.ajim.20200805.11

Copy | Download

@article{10.11648/j.ajim.20200805.11,
  author = {Victoria Serhiyenko and Marta Hotsko and Alexandr Serhiyenko and Oksana Snitynska and Ludmila Serhiyenko and Volodymyr Segin},
  title = {The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {5},
  pages = {197-203},
  doi = {10.11648/j.ajim.20200805.11},
  url = {https://doi.org/10.11648/j.ajim.20200805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200805.11},
  abstract = {Development of chronic complications in type 2 diabetes mellitus (T2DM), namely cardiac automonic neuropathy (CAN), had been implicated as an independent risk factor for cardiovascular mortality. This paper presents the results obtained during the study of possible alpha-lipoic acid (ALA) impact on the state of insulin resistance (IR), the content of some pro- and anti-inflammatory factors in patients with T2DM and definite stage of CAN. Our study involved 33 persons with diagnosed T2DM and definite CAN, which were allocated to one of two groups. The control group (15 patients) received standard hypoglycemic treatment, whereas the intervention group (18 patients) received ALA 600 mg in film-coated tablets/q.d. in addition to standard therapy. Treatment period was 3 months in duration. Levels of glycated hemoglobin A1c, glucose, immunoreactive insulin (IRI), leptin, interleukin (IL) IL-6 and IL-8, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) in the blood were measured. TNF-alpha/IL-10 ratio and Homeostasis model assessment IR (HOMA-IR) were calculated. The significant reduction in glucose, IRI, leptin concentration and HOMA-IR parameters; decrease in the pro-inflammatory link activity, namely hs-CRP, TNF-alpha, IL-6 and IL-8 levels, TNF-alpha/IL-10 ratio, with no changes in IL-10 content after 3 months of treatment was found. The results of our study demonstrated the decrease in the pro-inflammatory link activity after treatment and allow us to consider ALA as one of the promising drug for complex treatment of definite stage of CAN in patients with T2DM.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy
AU  - Victoria Serhiyenko
AU  - Marta Hotsko
AU  - Alexandr Serhiyenko
AU  - Oksana Snitynska
AU  - Ludmila Serhiyenko
AU  - Volodymyr Segin
Y1  - 2020/08/13
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200805.11
DO  - 10.11648/j.ajim.20200805.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 197
EP  - 203
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200805.11
AB  - Development of chronic complications in type 2 diabetes mellitus (T2DM), namely cardiac automonic neuropathy (CAN), had been implicated as an independent risk factor for cardiovascular mortality. This paper presents the results obtained during the study of possible alpha-lipoic acid (ALA) impact on the state of insulin resistance (IR), the content of some pro- and anti-inflammatory factors in patients with T2DM and definite stage of CAN. Our study involved 33 persons with diagnosed T2DM and definite CAN, which were allocated to one of two groups. The control group (15 patients) received standard hypoglycemic treatment, whereas the intervention group (18 patients) received ALA 600 mg in film-coated tablets/q.d. in addition to standard therapy. Treatment period was 3 months in duration. Levels of glycated hemoglobin A1c, glucose, immunoreactive insulin (IRI), leptin, interleukin (IL) IL-6 and IL-8, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) in the blood were measured. TNF-alpha/IL-10 ratio and Homeostasis model assessment IR (HOMA-IR) were calculated. The significant reduction in glucose, IRI, leptin concentration and HOMA-IR parameters; decrease in the pro-inflammatory link activity, namely hs-CRP, TNF-alpha, IL-6 and IL-8 levels, TNF-alpha/IL-10 ratio, with no changes in IL-10 content after 3 months of treatment was found. The results of our study demonstrated the decrease in the pro-inflammatory link activity after treatment and allow us to consider ALA as one of the promising drug for complex treatment of definite stage of CAN in patients with T2DM.
VL  - 8
IS  - 5
ER  -

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