American Journal of Internal Medicine

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Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia

Received: 16 June 2013    Accepted:     Published: 10 July 2013
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Abstract

Inflammatory process is not limited only local effects but could affect other organs and tissues. In this study, we investigated the influence of experimental tibial osteomyelitis on skin cells in dynamics. Although the skin located at the distance from the infection nidus it supposed to manifest intensive proliferation, reparation and apoptosis under adverse factors. Immunohistochemical assay of apoptotic regulators and proliferation-related proteins was carried out in fibroblasts of stratum reticulare in Wistar rats. Proliferating fibroblasts pool decrease confirmed by Ki67 expression decrease was revealed, overexpression of p53 and Bax was accompanied by Bcl-2 expression decrease. Findings suggest depressed regeneratory potential of fibroblasts, high probability of apoptosis in the skin cells at the persisting osteomyelitis that should be considered in dermatological practice.

DOI 10.11648/j.ajim.20130102.11
Published in American Journal of Internal Medicine (Volume 1, Issue 2, July 2013)
Page(s) 10-13
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Osteomyelitis, Tibia, Р53, Bax, Bcl-2, Ki-67, Fibroblasts, Stratum Reticulare, Apoptosis, Staphylococcus Аureus

References
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Author Information
  • Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia

  • Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia

  • Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia

  • Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia

  • Central Research Laboratory, Novosibirsk State Medical University, Novosibirsk, Russia

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  • APA Style

    Igor Zhurakovsky, Sergey Arkhypov, Marya Pustovetova, Igor Marinkin, Tatyana Kunts. (2013). Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia. American Journal of Internal Medicine, 1(2), 10-13. https://doi.org/10.11648/j.ajim.20130102.11

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    ACS Style

    Igor Zhurakovsky; Sergey Arkhypov; Marya Pustovetova; Igor Marinkin; Tatyana Kunts. Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia. Am. J. Intern. Med. 2013, 1(2), 10-13. doi: 10.11648/j.ajim.20130102.11

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    AMA Style

    Igor Zhurakovsky, Sergey Arkhypov, Marya Pustovetova, Igor Marinkin, Tatyana Kunts. Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia. Am J Intern Med. 2013;1(2):10-13. doi: 10.11648/j.ajim.20130102.11

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  • @article{10.11648/j.ajim.20130102.11,
      author = {Igor Zhurakovsky and Sergey Arkhypov and Marya Pustovetova and Igor Marinkin and Tatyana Kunts},
      title = {Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia},
      journal = {American Journal of Internal Medicine},
      volume = {1},
      number = {2},
      pages = {10-13},
      doi = {10.11648/j.ajim.20130102.11},
      url = {https://doi.org/10.11648/j.ajim.20130102.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.20130102.11},
      abstract = {Inflammatory process is not limited only local effects but could affect other organs and tissues. In this study, we investigated the influence of experimental tibial osteomyelitis on skin cells in dynamics.  Although the skin located at the distance from the infection nidus it supposed to manifest intensive proliferation, reparation and apoptosis under adverse factors. Immunohistochemical assay of apoptotic regulators and proliferation-related proteins was carried out in fibroblasts of stratum reticulare in Wistar rats. Proliferating fibroblasts pool decrease confirmed by Ki67 expression decrease was revealed, overexpression of p53 and Bax was accompanied by Bcl-2 expression decrease. Findings suggest depressed regeneratory potential of fibroblasts, high probability of apoptosis in the skin cells at the persisting osteomyelitis that should be considered in dermatological practice.},
     year = {2013}
    }
    

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    T1  - Functional Status of Skin Fibroblasts at Chronic Staphylococcus Aureus Osteomyelitis of the Tibia
    AU  - Igor Zhurakovsky
    AU  - Sergey Arkhypov
    AU  - Marya Pustovetova
    AU  - Igor Marinkin
    AU  - Tatyana Kunts
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    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
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    UR  - https://doi.org/10.11648/j.ajim.20130102.11
    AB  - Inflammatory process is not limited only local effects but could affect other organs and tissues. In this study, we investigated the influence of experimental tibial osteomyelitis on skin cells in dynamics.  Although the skin located at the distance from the infection nidus it supposed to manifest intensive proliferation, reparation and apoptosis under adverse factors. Immunohistochemical assay of apoptotic regulators and proliferation-related proteins was carried out in fibroblasts of stratum reticulare in Wistar rats. Proliferating fibroblasts pool decrease confirmed by Ki67 expression decrease was revealed, overexpression of p53 and Bax was accompanied by Bcl-2 expression decrease. Findings suggest depressed regeneratory potential of fibroblasts, high probability of apoptosis in the skin cells at the persisting osteomyelitis that should be considered in dermatological practice.
    VL  - 1
    IS  - 2
    ER  - 

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