Journal of Surgery

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The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs

Received: 30 March 2015    Accepted: 14 April 2015    Published: 30 April 2015
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Abstract

Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.

DOI 10.11648/j.js.20150302.12
Published in Journal of Surgery (Volume 3, Issue 2, April 2015)
Page(s) 12-17
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cost Analysis, Rectal Anastomoses, Fibrin-Based Biological Adhesive

References
[1] Lago Oliver J, Arjona Medina I, Martín García-Almenta E, et al. “Use of fibrin based biological glues in the prevention of anastomotic leaks in the high risk digestive tract: preliminary results of the multicentre, prospective, randomised, controlled, and simple blind phase iv clinical trial”: 1Protissucol001. Cir Esp. 2012;90:647-655.
[2] Kaidar-Person O, Rosenthal RJ, Wexner SD, et al. “Compression anastomosis: history and clinical considerations.”Am J Surg 2008;195:818-826.
[3] Midura EF, Hanseman D, Davis BR, et al. “Risk factors and consequences of anastomotic leak after colectomy: a national analysis”. Dis Colon Rectum 2015;58(3):333-338
[4] Snijders HS, Bakker IS, Dekker JW, et al. “High 1-year complication rate after anterior resection for rectal cancer”. J Gastrointest Surg 2014;18(4):831-838
[5] European Medicines Agency. “Questions and answers on the review of the fibrin sealants Tisseel, Tissucol, Artiss and Beriplast P (and associated names) given by spray application”. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Fibrin_sealants_31/WC500136248.pdf
[6] Avalos-González J, Portilla-de Buen E, Leal-Cortés CA, et al. “Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant”. World J Gastroenterol 2010;16:2793–2800.
[7] Toro A, Mannino M, Reale G, et al. “TachoSil use in abdominal surgery: a review”. J Blood Med 2011;2:31–36.
[8] Vakalopoulos KA, Daams F, Wu Z, et al. “Tissue adhesives in gastrointestinal anastomosis: a systematic review”. J Surg Res 2013;180:290-300.
[9] Hiura Y, Takiguchi S, Yamamoto K, et al. “Use of fibrin glue sealant with polyglycolic acid sheets to prevent pancreatic fistula formation after laparoscopic-assisted gastrectomy”. Surg Today 2013;43:527-533.
[10] Soga K, Ochiai T, Sonoyama T, et al. “Risk factors for postoperative pancreatic fistula in distal pancreatectomy”. Hepatogastroenterology 2011;58:1372-1376.
[11] Ikegami T, Maeda T, Kayashima H, et al. “Soft coagulation, polyglycolic acid felt, and fibrin glue for prevention of pancreatic fistula after distal pancreatectomy”. Surg Today 2011;41:1224-1227.
[12] Mita K, Ito H, Fukumoto M, et al. “A fibrin glue sealing method for the prevention of pancreatic fistula following distal pancreatectomy”. Hepatogastroenterology 2011;58:604-608.
[13] Ussat S, Lodes U, Wex C, et al. “Successful closure of a postoperative esophagobronchial fistula following esophageal resection using fibrin glue”. Dtsch Med Wochenschr 2013;138:1406-1409.
[14] Dhua AK, Ratan SK, Aggarwal SK. “Chylothorax after Primary Repair of Esophageal Atresia with Tracheo-esophageal Fistula: Successful Management by Biological Fibrin Glue”. APSP J Case Rep 2012;3:16.
[15] Ramón Rábago L, Moral I, Delgado M, et al. “Tratamiento endoscópico de fístulas gastrointestinales con un pegamento biológico tisular”. [Endoscopic treatment of gastrointestinal fistulas with biological tissue glue.] Gastroenterol Hepatol 2006;29:390-396.
[16] TissucolDuo®. Summary of Products Characteristics. Available at: http://www.aemps.gob.es/cima/pdfs/es/ft/60427/FT_60427.pdf
[17] General Council of Official Pharmaceuticals Colleges. Medicinal Products database. Bot plus web. Available at: www.portalfarma.com
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[19] Ashraf SQ, Burns EM, Jani A, et al. “The economic impact of anastomotic leakage after anterior resections in English NHS hospitals: are we adequately remunerating them?”Colorectal Dis 2013;15:190-198.
[20] Kang CY, Halabi WJ, Chaudhry OO, et al. “Risk factors for anastomotic leakage after anterior resection for rectal cancer”. JAMA Surg 2013;148:65-71.
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Author Information
  • Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain

  • Surgery Department, Southeast University Hospital.Arganda del Rey, Madrid, Spain

  • Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain

  • Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain; Basic Health Sciences Department, University Rey Juan Carlos, Madrid, Spain

  • Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain

  • Pharmacoeconomics & Outcomes Research Iberia, Madrid, Spain

Cite This Article
  • APA Style

    Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Estéves, Marta Cuadrado Ayuso, Fernando Turégano Fuentes, et al. (2015). The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. Journal of Surgery, 3(2), 12-17. https://doi.org/10.11648/j.js.20150302.12

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    ACS Style

    Jesús Lago Oliver; Salvador Argudo Garijo; Mauricio Burneo Estéves; Marta Cuadrado Ayuso; Fernando Turégano Fuentes, et al. The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. J. Surg. 2015, 3(2), 12-17. doi: 10.11648/j.js.20150302.12

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    AMA Style

    Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Estéves, Marta Cuadrado Ayuso, Fernando Turégano Fuentes, et al. The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. J Surg. 2015;3(2):12-17. doi: 10.11648/j.js.20150302.12

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  • @article{10.11648/j.js.20150302.12,
      author = {Jesús Lago Oliver and Salvador Argudo Garijo and Mauricio Burneo Estéves and Marta Cuadrado Ayuso and Fernando Turégano Fuentes and Araceli Casado Gómez},
      title = {The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs},
      journal = {Journal of Surgery},
      volume = {3},
      number = {2},
      pages = {12-17},
      doi = {10.11648/j.js.20150302.12},
      url = {https://doi.org/10.11648/j.js.20150302.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.js.20150302.12},
      abstract = {Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs
    AU  - Jesús Lago Oliver
    AU  - Salvador Argudo Garijo
    AU  - Mauricio Burneo Estéves
    AU  - Marta Cuadrado Ayuso
    AU  - Fernando Turégano Fuentes
    AU  - Araceli Casado Gómez
    Y1  - 2015/04/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.js.20150302.12
    DO  - 10.11648/j.js.20150302.12
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 12
    EP  - 17
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20150302.12
    AB  - Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.
    VL  - 3
    IS  - 2
    ER  - 

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