Gangrenous Colitis in a Patient with Polypharmacy: A Case Study

Hassan Malik; Sivananthan Suntharalingam; Muhammad Majid Ali

doi:doi:10.11648/j.js.20160401.12

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Gangrenous Colitis in a Patient with Polypharmacy: A Case Study

Hassan Malik, Sivananthan Suntharalingam, Muhammad Majid Ali

Published in Journal of Surgery (Volume 4, Issue 1)

Received: 13 January 2016 Accepted: 25 January 2016 Published: 29 February 2016

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Abstract

A 20-year-old female, otherwise fit and well, was admitted to intensive care unit intubated with polypharmacy secondary to drug over dose. She developed a seizure episode and a rise in serum lactate within 24 hours of admission, followed by abdominal distension, with metabolic acidosis and a further elevation of serum lactate levels. CT abdomen revealed gangrenous colitis, which was confirmed on laparotomy. The patient underwent subtotal colectomy with end ileostomy, which was further complicated a week later by necrosis of the stoma due to knotting of the small bowel around the ileostomy loop. She underwent another laparotomy, for fixation of internal herniation of small bowel loops as well re-fashioning of the end ileostomy, and had an uneventful recovery. Final pathology of the colon showed ischaemic colitis with mural necrosis, peritonitis and viable resection margins.

Published in	Journal of Surgery (Volume 4, Issue 1)
DOI	10.11648/j.js.20160401.12
Page(s)	4-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Young Female, Gangrenous Colitis, Ishaemic Colitis(IC), Polypharmacy, CT, Laparotomy, Ileostomy

References

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[2]	Stamos, M. J. Intestinal ischemia and infarction. In: Mazier W. P., Levien D. H., Luchtefeld M. A., et al, eds. Surgery of the colon, rectum and anus. Philadelphia: WB Saunders; 1995: 685–718.
[3]	Boley SJ, Schwartz S, Lash J, Sternhill V. Reversible vascular occlusion of the colon. Surg Gynecol Obstet. 1963; 116: 53–60.
[4]	Greenwald DA, Brandt LJ. Colonic ischemia. J Clin Gastroenterol. 1998; 27: 122–128.
[5]	Marston A, Pheils MT, Thomas ML, Morson BC. Ischaemic colitis. Gut. 1966; 7(1): 1–15.
[6]	Longo WE, Ballantyne GH, Gusberg RJ. Ischemic colitis: patterns and prognosis. Dis Colon Rectum. 1992; 35(8): 726–730.
[7]	Stamos MJ. Intestinal ischemia and infarction. In: Mazier WP, Levien DH, Luchtefeld MA, Senagore AJ, editors. Surgery of the Colon, Rectum and Anus. Philadelphia: WB Saunders; 1995. pp. 685–718.
[8]	O. A. Preventza, K. Lazarides, M. D. Sawyer Ischemic colitis in young adults: a single-institution experience J Gastrointest Surg, 5 (2001), pp. 388–392
[9]	Koh KS, Danzinger RG. Massive intestinal infarction in young women: complication of use of oral contraceptives? Can Med Assoc J. 1977; 116: 513–515.
[10]	M. S. Cappell Colonic toxicity of administered drugs and chemicals Am J Gastroenterol, 99 (2004), pp. 1175–1190
[11]	Reinus JF, Brandt LJ, Boley SJ. Ischemic diseases of the bowel. Gastroenterol Clin North Am 1990; 19: 319-343
[12]	Habu Y, Tahashi K, Kiyota K, et al. Reevaluation of clinical features of ischemic colitis: analysis of 68 consecutive cases diagnosed by early colonoscopy. Scand J Gastroenterol 1996; 31: 881-886.

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APA Style

Hassan Malik, Sivananthan Suntharalingam, Muhammad Majid Ali. (2016). Gangrenous Colitis in a Patient with Polypharmacy: A Case Study. Journal of Surgery, 4(1), 4-7. https://doi.org/10.11648/j.js.20160401.12

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ACS Style

Hassan Malik; Sivananthan Suntharalingam; Muhammad Majid Ali. Gangrenous Colitis in a Patient with Polypharmacy: A Case Study. J. Surg. 2016, 4(1), 4-7. doi: 10.11648/j.js.20160401.12

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AMA Style

Hassan Malik, Sivananthan Suntharalingam, Muhammad Majid Ali. Gangrenous Colitis in a Patient with Polypharmacy: A Case Study. J Surg. 2016;4(1):4-7. doi: 10.11648/j.js.20160401.12

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@article{10.11648/j.js.20160401.12,
  author = {Hassan Malik and Sivananthan Suntharalingam and Muhammad Majid Ali},
  title = {Gangrenous Colitis in a Patient with Polypharmacy: A Case Study},
  journal = {Journal of Surgery},
  volume = {4},
  number = {1},
  pages = {4-7},
  doi = {10.11648/j.js.20160401.12},
  url = {https://doi.org/10.11648/j.js.20160401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20160401.12},
  abstract = {A 20-year-old female, otherwise fit and well, was admitted to intensive care unit intubated with polypharmacy secondary to drug over dose. She developed a seizure episode and a rise in serum lactate within 24 hours of admission, followed by abdominal distension, with metabolic acidosis and a further elevation of serum lactate levels. CT abdomen revealed gangrenous colitis, which was confirmed on laparotomy. The patient underwent subtotal colectomy with end ileostomy, which was further complicated a week later by necrosis of the stoma due to knotting of the small bowel around the ileostomy loop. She underwent another laparotomy, for fixation of internal herniation of small bowel loops as well re-fashioning of the end ileostomy, and had an uneventful recovery. Final pathology of the colon showed ischaemic colitis with mural necrosis, peritonitis and viable resection margins.},
 year = {2016}
}

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TY  - JOUR
T1  - Gangrenous Colitis in a Patient with Polypharmacy: A Case Study
AU  - Hassan Malik
AU  - Sivananthan Suntharalingam
AU  - Muhammad Majid Ali
Y1  - 2016/02/29
PY  - 2016
N1  - https://doi.org/10.11648/j.js.20160401.12
DO  - 10.11648/j.js.20160401.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 4
EP  - 7
PB  - Science Publishing Group
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AB  - A 20-year-old female, otherwise fit and well, was admitted to intensive care unit intubated with polypharmacy secondary to drug over dose. She developed a seizure episode and a rise in serum lactate within 24 hours of admission, followed by abdominal distension, with metabolic acidosis and a further elevation of serum lactate levels. CT abdomen revealed gangrenous colitis, which was confirmed on laparotomy. The patient underwent subtotal colectomy with end ileostomy, which was further complicated a week later by necrosis of the stoma due to knotting of the small bowel around the ileostomy loop. She underwent another laparotomy, for fixation of internal herniation of small bowel loops as well re-fashioning of the end ileostomy, and had an uneventful recovery. Final pathology of the colon showed ischaemic colitis with mural necrosis, peritonitis and viable resection margins.
VL  - 4
IS  - 1
ER  -

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Author Information

Hassan Malik

Hervey Bay Hospital, Queensland, Australia
Sivananthan Suntharalingam

Hervey Bay Hospital, Queensland, Australia
Muhammad Majid Ali

Hervey Bay Hospital, Queensland, Australia

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APA Style

Hassan Malik, Sivananthan Suntharalingam, Muhammad Majid Ali. (2016). Gangrenous Colitis in a Patient with Polypharmacy: A Case Study. Journal of Surgery, 4(1), 4-7. https://doi.org/10.11648/j.js.20160401.12

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ACS Style

Hassan Malik; Sivananthan Suntharalingam; Muhammad Majid Ali. Gangrenous Colitis in a Patient with Polypharmacy: A Case Study. J. Surg. 2016, 4(1), 4-7. doi: 10.11648/j.js.20160401.12

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AMA Style

Hassan Malik, Sivananthan Suntharalingam, Muhammad Majid Ali. Gangrenous Colitis in a Patient with Polypharmacy: A Case Study. J Surg. 2016;4(1):4-7. doi: 10.11648/j.js.20160401.12

Copy | Download

@article{10.11648/j.js.20160401.12,
  author = {Hassan Malik and Sivananthan Suntharalingam and Muhammad Majid Ali},
  title = {Gangrenous Colitis in a Patient with Polypharmacy: A Case Study},
  journal = {Journal of Surgery},
  volume = {4},
  number = {1},
  pages = {4-7},
  doi = {10.11648/j.js.20160401.12},
  url = {https://doi.org/10.11648/j.js.20160401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20160401.12},
  abstract = {A 20-year-old female, otherwise fit and well, was admitted to intensive care unit intubated with polypharmacy secondary to drug over dose. She developed a seizure episode and a rise in serum lactate within 24 hours of admission, followed by abdominal distension, with metabolic acidosis and a further elevation of serum lactate levels. CT abdomen revealed gangrenous colitis, which was confirmed on laparotomy. The patient underwent subtotal colectomy with end ileostomy, which was further complicated a week later by necrosis of the stoma due to knotting of the small bowel around the ileostomy loop. She underwent another laparotomy, for fixation of internal herniation of small bowel loops as well re-fashioning of the end ileostomy, and had an uneventful recovery. Final pathology of the colon showed ischaemic colitis with mural necrosis, peritonitis and viable resection margins.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Gangrenous Colitis in a Patient with Polypharmacy: A Case Study
AU  - Hassan Malik
AU  - Sivananthan Suntharalingam
AU  - Muhammad Majid Ali
Y1  - 2016/02/29
PY  - 2016
N1  - https://doi.org/10.11648/j.js.20160401.12
DO  - 10.11648/j.js.20160401.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 4
EP  - 7
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20160401.12
AB  - A 20-year-old female, otherwise fit and well, was admitted to intensive care unit intubated with polypharmacy secondary to drug over dose. She developed a seizure episode and a rise in serum lactate within 24 hours of admission, followed by abdominal distension, with metabolic acidosis and a further elevation of serum lactate levels. CT abdomen revealed gangrenous colitis, which was confirmed on laparotomy. The patient underwent subtotal colectomy with end ileostomy, which was further complicated a week later by necrosis of the stoma due to knotting of the small bowel around the ileostomy loop. She underwent another laparotomy, for fixation of internal herniation of small bowel loops as well re-fashioning of the end ileostomy, and had an uneventful recovery. Final pathology of the colon showed ischaemic colitis with mural necrosis, peritonitis and viable resection margins.
VL  - 4
IS  - 1
ER  -

Copy | Download