Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration
Journal of Surgery
Volume 4, Issue 2, April 2016, Pages: 49-59
Received: May 22, 2016; Published: May 23, 2016
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Author
Komal Sharma, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Abstract
Advancements in neurosurgical research have been central to understanding the underlying process of neural growth and regeneration (neurogenesis) and its application in the treatment and management of neurological pathologies. Recent work has shown the adult brain and central nervous system (CNS) to contain neuronal progenitors, precursor molecules as well as stem cells which play key roles in the new generation of neurones, astrocytes and oligodendrocytes. Whilst also challenging the previous dogma that no new neurones are born into the adult mammalian CNS and brain; this paper draws upon and presents an up-to-date picture of currently used “in vitro” and “in vivo” models for the study of novel techniques concerning the integration of neurones into existing neural circuitry. Breakthrough studies in Axonal Regeneration; The Application of Growth Factors; Stem cell grafting and proliferation; Synthetic materials technology; are just a few examples of key areas which have gained extensive interest, to ensure the successful clinical application of neurogenesis in various neurological pathologies. Challenges in the field are also addressed, where a future outlook to improve these novel techniques and potential areas of expandable research is also indicated.
Keywords
Biosynthetic Materials, Neural Growth, Neural Regeneration, Neurogenesis, Neurosurgery, Neurosurgical Research, Surgery, Surgical Research
To cite this article
Komal Sharma, Neurosurgical Research – Cutting Edge: Recent Advancements and Shortcomings in Neural Growth and Regeneration, Journal of Surgery. Vol. 4, No. 2, 2016, pp. 49-59. doi: 10.11648/j.js.20160402.20
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