Journal of Surgery

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Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia

Received: 10 July 2018    Accepted: 20 July 2018    Published: 14 August 2018
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Abstract

Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.

DOI 10.11648/j.js.20180604.16
Published in Journal of Surgery (Volume 6, Issue 4, August 2018)
Page(s) 107-111
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Acute Abdomen, Mesenteric Ischemia, α -glutathione S-transferase

References
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[4] Van den Heijkant TC, Aerts BA, Teijink JA, et al. Challenges in diagnosing mesenteric ischemia. World J Gastroenterol. 2013; 19:1338–41.
[5] Yusuf Tanrıkulu, Ceren Şen Tanrıkulu, Mehmet Zafer et al. Diagnostic utility of the neutrophil-lymphocyte ratio in patients with acute mesenteric ischemia: A retrospective cohort study. Ulus Travma Acil Cerrahi Derg. 2016; 22(4):344–9.
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Author Information
  • General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Emergency & Traumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt

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  • APA Style

    Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. (2018). Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. Journal of Surgery, 6(4), 107-111. https://doi.org/10.11648/j.js.20180604.16

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    ACS Style

    Ahmed Abdel Fattah Elshoura; Hala Desouky Ibrahim; Sahar Mohey Hazzaa; Ola Abdel Fattah Elshora; Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J. Surg. 2018, 6(4), 107-111. doi: 10.11648/j.js.20180604.16

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    AMA Style

    Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J Surg. 2018;6(4):107-111. doi: 10.11648/j.js.20180604.16

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  • @article{10.11648/j.js.20180604.16,
      author = {Ahmed Abdel Fattah Elshoura and Hala Desouky Ibrahim and Sahar Mohey Hazzaa and Ola Abdel Fattah Elshora and Gamal Ibrahim Moussa},
      title = {Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia},
      journal = {Journal of Surgery},
      volume = {6},
      number = {4},
      pages = {107-111},
      doi = {10.11648/j.js.20180604.16},
      url = {https://doi.org/10.11648/j.js.20180604.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.js.20180604.16},
      abstract = {Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia
    AU  - Ahmed Abdel Fattah Elshoura
    AU  - Hala Desouky Ibrahim
    AU  - Sahar Mohey Hazzaa
    AU  - Ola Abdel Fattah Elshora
    AU  - Gamal Ibrahim Moussa
    Y1  - 2018/08/14
    PY  - 2018
    N1  - https://doi.org/10.11648/j.js.20180604.16
    DO  - 10.11648/j.js.20180604.16
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 107
    EP  - 111
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20180604.16
    AB  - Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.
    VL  - 6
    IS  - 4
    ER  - 

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