Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia
Journal of Surgery
Volume 6, Issue 4, August 2018, Pages: 107-111
Received: Jul. 10, 2018; Accepted: Jul. 20, 2018; Published: Aug. 14, 2018
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Ahmed Abdel Fattah Elshoura, General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Hala Desouky Ibrahim, Emergency & Traumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Sahar Mohey Hazzaa, Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Ola Abdel Fattah Elshora, Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Gamal Ibrahim Moussa, General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt
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Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.
Acute Abdomen, Mesenteric Ischemia, α -glutathione S-transferase
To cite this article
Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa, Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia, Journal of Surgery. Vol. 6, No. 4, 2018, pp. 107-111. doi: 10.11648/j.js.20180604.16
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