Invasive Lobular Carcinoma within a Fibroadenoma: A Case Report and Review of the Literature
Journal of Surgery
Volume 7, Issue 2, April 2019, Pages: 35-37
Received: Feb. 18, 2019;
Accepted: Apr. 9, 2019;
Published: May 6, 2019
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Dimitrios Kokkonis, Department of Breast Surgery, West Middlesex University Hospital, London, United Kingdom
Mohamed Razick Sait, Department of Breast Surgery, West Middlesex University Hospital, London, United Kingdom
Anne Thorpe, Department of Breast Surgery, West Middlesex University Hospital, London, United Kingdom
Ralia Bunza, Department of Breast Surgery, West Middlesex University Hospital, London, United Kingdomi
Rajiv Vashisht, Department of Breast Surgery, West Middlesex University Hospital, London, United Kingdom
Musa Barkeji, Department of Breast Surgery, West Middlesex University Hospital, London, United Kingdom
Fibroadenoma (FAD) is the most common type of breast lesion especially in young female individuals. Although malignant transformation in FAD is rare, several reports have described a higher risk of subsequent breast carcinoma amongst patients who have FAD with specific histologic features. The case of a 30-year-old female exhibiting invasive lobular carcinoma arising within an excised fibroadenoma is being presented. The literature was reviewed with regards to the increased likelihood of developing breast cancer in patients with FADs. The incidence of cancer found in an excised FAD is extremely low, but there are specific proliferative changes on the histology after a core needle biopsy, that they should warrant excision biopsy.
Mohamed Razick Sait,
Invasive Lobular Carcinoma within a Fibroadenoma: A Case Report and Review of the Literature, Journal of Surgery.
Vol. 7, No. 2,
2019, pp. 35-37.
Dupont W, Page D, Pari F, Vnencak-Jones C, Plummer W, Rados M Schyler. Long-Term Risk of Breast Cancer in Women with Fibroadenoma. N Engl J Med 1994; 331(1):10-15.
Kuijper A, Mommers EC, van der Wall E, van Diest PJ. Histopathology of fibroadenoma of the breast. Am J Clin Pathol 2001; 115(5):736-742.
McDivitt RW, Stevens JA, Lee NC, Wingo PA, Rubin GL, Gersell D. The Cancer and Steroid Hormone Study Group. Histologic types of benign breast disease and the risk for breast cancer. Cancer 1992; 69(6):1408-1414.
Kabat GC, Jones JG, Olson N, et al. A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer. Cancer Causes Control 2010; 21(6):821-828.
El-Wakeel H, Umpleby HC. Systematic review of fibroadenoma as a risk factor for breast cancer. Breast 2003; 12(5):302-307.
Bin Hua, Jing-Yong Xu, Lei Jiang, Zheng Wang. Fibroadenoma with an unexpected lobular. carcinoma in situ: a case report and review of the literature. Oncology Letters 1 2015; 1397-1401.
Buzanowski-Konakry K, Harrison EG Jr and Payne WS: Lobular carcinoma arising in fibroadenomas of the breast. Cancer 1975; 35:450-456.
Martin PM, Kutten F, Serment H, Jarvis MP. Studies on clinical, hormonal and pathological correlations in breast fibroadenomas. J Steroid Biochem 1978; 9:1251-2.
World Health organization Histological typing of breast tumours. 2nd ed. Geneva: WHO 1981.
Hughes LE, Mansel RE, Webster DJT, Aberration of normal development and involution: a new perspective on pathogenesis and nomenclature of benign breast disorders. Lancet 1987; 11:1316-9.
Carty N J, Carter C, Rubin C, Ravichandran, Royal GT. Taylor I. Management of fibroadenoma of the breast. Ann R Coll Surg Engl 1995; 77:127-30.
Deschenes L, Jacob, Fabia J, Christen A: Beware of breast fibroadenomas in middle-aged wome. Can j Surg 1985; 28:372-374.
Iyengar KR, Peh SC, Yip CH and Vijayananthan A: Infiltrating duct carcinoma within a fibroadenoma. Indian J Cancer 2009; 46:244-246.
Abe H, Hanasawa K, Naitoh H, et al: Invasive ductal carcinoma within a fibroadenoma of the breast. Int J Clin Oncol 2004; 9: 334-338.
Pick PW and Iossifides IA: Occurrence of breast carcinoma within a fibroadenoma. A review. Arch Pathol Lab Med 1984; 108:590-594.
Fukuda M, Nagao K, Nishimuta R, Matsuda M, Baba K, Ueno Y, Morinaga H, Omachi H, Hamada T: Carcinoma arising in fibroadenoma of the breast- a case report and review of the literature. Jpn J Surg 1989; 19:593-596.
Aziza Nassar, Daniel W., Visscher, Amy C. Degnim, Messr. Ryan D. Frank, Messr. Robert A. Vierkant, Marlene Frost, Derek C. Radisky, Celine Vachon, Ruth A. Kraft, Lynn C. Hartmann, Karthik Ghosh. Complex Fibroadenoma and Breast Cancer Risk: Mayo Clinic Benign Breast Disease Cohort Study. Breast Cancer Res Treat 2015; 153(2): 397-405.
Neville G, Neill CO, Murphy R, Corrigan M, Redmond PH, Feeley L, Bennett MW, O'Connell F, Browne TJ. Is excision biopsy of fibroadenomas based solely on size criteria warranted? Breast J 2018 May; 25. doi: 10.1111/tbj.13069.
Yu Ting Wu, Shou-Tung Chen, Chi-Jung Chen, Yao-Lung Kuo, Ling-Ming Tseng, Dar-Ren Chen, Shou-Jen Kuo, Hung-Wen Lai. Breast cancer arising within fibroadenoma: collective analysis of case reports in the literature and hints on treatment policy. World Journal of Surgical Oncology 2014; 12:335-38.
Tiu CM, Chou YH, Chiou SY, Hsu CY, Chen SP, Chiang HR, Lai CR, Tseng LM, Wang HK, Chiou HJ: Development of a carcinoma in situ in a fibroadenoma: color Doppler sonographic demonstration. J Ultrasound Med 2006; 25:1335-1338.