Background: The etiology, treatment and prevention of Nonalcoholic fatty liver disease (NAFLD) after pancreatoduodenectomy (PD) remain largely unknown. We aimed to elucidate the risk factors for NAFLD after PD and investigate the nutritional effects of zinc medication. Methods: We retrospectively examined 109 patients who underwent PD between 2013 and 2017. We diagnosed the postoperative NAFLD using CT attenuation at six months later. We identified the risk factors for postoperative NAFLD among perioperative factors and analyzed the nutritional effect of zinc medication at six months after surgery. Results: We diagnosed 27 patients with NAFLD after PD. A univariate analysis showed that pancreas cancer (p = 0.029), operative time (p = 0.008), blood loss (p = 0.034), postoperative diarrhea (p < 0.001) and zinc medication (p < 0.001) were associated with postoperative NAFLD. A multivariate analysis demonstrated that zinc medication was the most important factor for the prevention of NAFLD after PD. All patients who received zinc also took pancreatic enzyme simultaneously and showed a significantly lower rate of body weight loss than in patients without zinc at six months after PD (p = 0.041). These patients showed a significantly higher total cholesterol level (p = 0.006) and higher serum zinc level (p<0.001). Furthermore, significantly fewer cases of postoperative NAFLD were noted among the patients who received zinc than among those who did not receive it (5.7% vs 33.8%: p = 0.001). Conclusion: These results suggest that zinc administration might improve the postoperative nutritional status and prevent NAFLD after PD.
| Published in | Journal of Surgery (Volume 7, Issue 5) |
| DOI | 10.11648/j.js.20190705.17 |
| Page(s) | 148-153 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Pancreatoduodenectomy, Nonalcoholic Fatty Liver Disease, Zinc
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APA Style
Atsushi Miyosh, Hiroki Koga, Satomi Nakamura, Hiroaki Nakamura, Kohei Yamada, et al. (2019). Effects of Zinc on Non-alcoholic Fatty Liver Disease After Pancreatoduodenectomy. Journal of Surgery, 7(5), 148-153. https://doi.org/10.11648/j.js.20190705.17
ACS Style
Atsushi Miyosh; Hiroki Koga; Satomi Nakamura; Hiroaki Nakamura; Kohei Yamada, et al. Effects of Zinc on Non-alcoholic Fatty Liver Disease After Pancreatoduodenectomy. J. Surg. 2019, 7(5), 148-153. doi: 10.11648/j.js.20190705.17
AMA Style
Atsushi Miyosh, Hiroki Koga, Satomi Nakamura, Hiroaki Nakamura, Kohei Yamada, et al. Effects of Zinc on Non-alcoholic Fatty Liver Disease After Pancreatoduodenectomy. J Surg. 2019;7(5):148-153. doi: 10.11648/j.js.20190705.17
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Download@article{10.11648/j.js.20190705.17,
author = {Atsushi Miyosh and Hiroki Koga and Satomi Nakamura and Hiroaki Nakamura and Kohei Yamada and Hiroshi Kubo and Masatsugu Hiraki and Osamu Ikeda and Toshiya Tanaka and Kenji Kitahara and Seiji Sato and Hirokazu Noshiro},
title = {Effects of Zinc on Non-alcoholic Fatty Liver Disease After Pancreatoduodenectomy},
journal = {Journal of Surgery},
volume = {7},
number = {5},
pages = {148-153},
doi = {10.11648/j.js.20190705.17},
url = {https://doi.org/10.11648/j.js.20190705.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20190705.17},
abstract = {Background: The etiology, treatment and prevention of Nonalcoholic fatty liver disease (NAFLD) after pancreatoduodenectomy (PD) remain largely unknown. We aimed to elucidate the risk factors for NAFLD after PD and investigate the nutritional effects of zinc medication. Methods: We retrospectively examined 109 patients who underwent PD between 2013 and 2017. We diagnosed the postoperative NAFLD using CT attenuation at six months later. We identified the risk factors for postoperative NAFLD among perioperative factors and analyzed the nutritional effect of zinc medication at six months after surgery. Results: We diagnosed 27 patients with NAFLD after PD. A univariate analysis showed that pancreas cancer (p = 0.029), operative time (p = 0.008), blood loss (p = 0.034), postoperative diarrhea (p < 0.001) and zinc medication (p < 0.001) were associated with postoperative NAFLD. A multivariate analysis demonstrated that zinc medication was the most important factor for the prevention of NAFLD after PD. All patients who received zinc also took pancreatic enzyme simultaneously and showed a significantly lower rate of body weight loss than in patients without zinc at six months after PD (p = 0.041). These patients showed a significantly higher total cholesterol level (p = 0.006) and higher serum zinc level (p<0.001). Furthermore, significantly fewer cases of postoperative NAFLD were noted among the patients who received zinc than among those who did not receive it (5.7% vs 33.8%: p = 0.001). Conclusion: These results suggest that zinc administration might improve the postoperative nutritional status and prevent NAFLD after PD.},
year = {2019}
}
TY - JOUR T1 - Effects of Zinc on Non-alcoholic Fatty Liver Disease After Pancreatoduodenectomy AU - Atsushi Miyosh AU - Hiroki Koga AU - Satomi Nakamura AU - Hiroaki Nakamura AU - Kohei Yamada AU - Hiroshi Kubo AU - Masatsugu Hiraki AU - Osamu Ikeda AU - Toshiya Tanaka AU - Kenji Kitahara AU - Seiji Sato AU - Hirokazu Noshiro Y1 - 2019/09/26 PY - 2019 N1 - https://doi.org/10.11648/j.js.20190705.17 DO - 10.11648/j.js.20190705.17 T2 - Journal of Surgery JF - Journal of Surgery JO - Journal of Surgery SP - 148 EP - 153 PB - Science Publishing Group SN - 2330-0930 UR - https://doi.org/10.11648/j.js.20190705.17 AB - Background: The etiology, treatment and prevention of Nonalcoholic fatty liver disease (NAFLD) after pancreatoduodenectomy (PD) remain largely unknown. We aimed to elucidate the risk factors for NAFLD after PD and investigate the nutritional effects of zinc medication. Methods: We retrospectively examined 109 patients who underwent PD between 2013 and 2017. We diagnosed the postoperative NAFLD using CT attenuation at six months later. We identified the risk factors for postoperative NAFLD among perioperative factors and analyzed the nutritional effect of zinc medication at six months after surgery. Results: We diagnosed 27 patients with NAFLD after PD. A univariate analysis showed that pancreas cancer (p = 0.029), operative time (p = 0.008), blood loss (p = 0.034), postoperative diarrhea (p < 0.001) and zinc medication (p < 0.001) were associated with postoperative NAFLD. A multivariate analysis demonstrated that zinc medication was the most important factor for the prevention of NAFLD after PD. All patients who received zinc also took pancreatic enzyme simultaneously and showed a significantly lower rate of body weight loss than in patients without zinc at six months after PD (p = 0.041). These patients showed a significantly higher total cholesterol level (p = 0.006) and higher serum zinc level (p<0.001). Furthermore, significantly fewer cases of postoperative NAFLD were noted among the patients who received zinc than among those who did not receive it (5.7% vs 33.8%: p = 0.001). Conclusion: These results suggest that zinc administration might improve the postoperative nutritional status and prevent NAFLD after PD. VL - 7 IS - 5 ER -
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