Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review

Isabella Opoku; Lin Qin Tang; Lidan Jiang; Dan Dan Wang; Xu Yueqiao; Ling Feng; Wang Ning

doi:doi:10.11648/j.js.20210904.19

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Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review

Isabella Opoku, Lin Qin Tang, Lidan Jiang, Dan Dan Wang, Xu Yueqiao, Ling Feng, Wang Ning

Published in Journal of Surgery (Volume 9, Issue 4)

Received: 16 May 2021 Accepted: 31 May 2021 Published: 2 August 2021

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Abstract

Background: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a serious and uncommon complication which can be developed months or years after a Kidney transplant. Immunosuppressive agents administered before and after transplantation to minimize the chances of allograft rejection has proved to be a double-edged sword that puts the host at risk of infectious, neoplastic and vascular diseases, including PCNS-PTLD. The immunosuppressive therapy leads to decreased innate malignant and viral immune surveillance and this has been shown to play a role in lymphoproliferative diseases after transplantation. In most cases, PCNS-PTLD is Epstein–Barr virus related. Case Description: A 60-year-old female with history of kidney transplant presented to the emergency room with history of low fever, dizziness nausea and vomiting for 1 month. MRI and CT scans showed a mass cerebellar lesion and a biopsy revealed Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD). Conclusion: This case highlights the need for a careful long-term follow up of patients with kidney transplant. PCNS-PTLD represents a continuing long-term risk after transplantation, although less common. This case report supports observational data that suggests that peripheral blood screening for EBV DNA does not seem helpful for identification of PCNS-PTLD. Suspicion of PCNS PTLD should be considered when patients with long-term history of kidney transplant present neurological complaints.

Published in	Journal of Surgery (Volume 9, Issue 4)
DOI	10.11648/j.js.20210904.19
Page(s)	193-198
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Central Nervous System, Primary B Cell Lymphoma, Transplantation, Kidney

References

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APA Style

Isabella Opoku, Lin Qin Tang, Lidan Jiang, Dan Dan Wang, Xu Yueqiao, et al. (2021). Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review. Journal of Surgery, 9(4), 193-198. https://doi.org/10.11648/j.js.20210904.19

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ACS Style

Isabella Opoku; Lin Qin Tang; Lidan Jiang; Dan Dan Wang; Xu Yueqiao, et al. Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review. J. Surg. 2021, 9(4), 193-198. doi: 10.11648/j.js.20210904.19

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AMA Style

Isabella Opoku, Lin Qin Tang, Lidan Jiang, Dan Dan Wang, Xu Yueqiao, et al. Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review. J Surg. 2021;9(4):193-198. doi: 10.11648/j.js.20210904.19

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@article{10.11648/j.js.20210904.19,
  author = {Isabella Opoku and Lin Qin Tang and Lidan Jiang and Dan Dan Wang and Xu Yueqiao and Ling Feng and Wang Ning},
  title = {Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review},
  journal = {Journal of Surgery},
  volume = {9},
  number = {4},
  pages = {193-198},
  doi = {10.11648/j.js.20210904.19},
  url = {https://doi.org/10.11648/j.js.20210904.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20210904.19},
  abstract = {Background: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a serious and uncommon complication which can be developed months or years after a Kidney transplant. Immunosuppressive agents administered before and after transplantation to minimize the chances of allograft rejection has proved to be a double-edged sword that puts the host at risk of infectious, neoplastic and vascular diseases, including PCNS-PTLD. The immunosuppressive therapy leads to decreased innate malignant and viral immune surveillance and this has been shown to play a role in lymphoproliferative diseases after transplantation. In most cases, PCNS-PTLD is Epstein–Barr virus related. Case Description: A 60-year-old female with history of kidney transplant presented to the emergency room with history of low fever, dizziness nausea and vomiting for 1 month. MRI and CT scans showed a mass cerebellar lesion and a biopsy revealed Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD). Conclusion: This case highlights the need for a careful long-term follow up of patients with kidney transplant. PCNS-PTLD represents a continuing long-term risk after transplantation, although less common. This case report supports observational data that suggests that peripheral blood screening for EBV DNA does not seem helpful for identification of PCNS-PTLD. Suspicion of PCNS PTLD should be considered when patients with long-term history of kidney transplant present neurological complaints.},
 year = {2021}
}

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TY  - JOUR
T1  - Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review
AU  - Isabella Opoku
AU  - Lin Qin Tang
AU  - Lidan Jiang
AU  - Dan Dan Wang
AU  - Xu Yueqiao
AU  - Ling Feng
AU  - Wang Ning
Y1  - 2021/08/02
PY  - 2021
N1  - https://doi.org/10.11648/j.js.20210904.19
DO  - 10.11648/j.js.20210904.19
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 193
EP  - 198
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20210904.19
AB  - Background: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a serious and uncommon complication which can be developed months or years after a Kidney transplant. Immunosuppressive agents administered before and after transplantation to minimize the chances of allograft rejection has proved to be a double-edged sword that puts the host at risk of infectious, neoplastic and vascular diseases, including PCNS-PTLD. The immunosuppressive therapy leads to decreased innate malignant and viral immune surveillance and this has been shown to play a role in lymphoproliferative diseases after transplantation. In most cases, PCNS-PTLD is Epstein–Barr virus related. Case Description: A 60-year-old female with history of kidney transplant presented to the emergency room with history of low fever, dizziness nausea and vomiting for 1 month. MRI and CT scans showed a mass cerebellar lesion and a biopsy revealed Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD). Conclusion: This case highlights the need for a careful long-term follow up of patients with kidney transplant. PCNS-PTLD represents a continuing long-term risk after transplantation, although less common. This case report supports observational data that suggests that peripheral blood screening for EBV DNA does not seem helpful for identification of PCNS-PTLD. Suspicion of PCNS PTLD should be considered when patients with long-term history of kidney transplant present neurological complaints.
VL  - 9
IS  - 4
ER  -

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Author Information

Isabella Opoku

Department of Neurosurgery, China International Neuroscience Institute (China-INI), Xuanwu Hospital- Capital Medical University, Beijing, China
Lin Qin Tang

Department of Neurosurgery, China International Neuroscience Institute (China-INI), Xuanwu Hospital- Capital Medical University, Beijing, China
Lidan Jiang

Department of Neurosurgery, China International Neuroscience Institute (China-INI), Xuanwu Hospital- Capital Medical University, Beijing, China
Dan Dan Wang

Department of Pathology, China International Neuroscience Institute (China-INI), Xuanwu Hospital - Capital Medical University, Beijing, China
Xu Yueqiao

Department of Neurosurgery, China International Neuroscience Institute (China-INI), Xuanwu Hospital- Capital Medical University, Beijing, China
Ling Feng

Department of Neurosurgery, China International Neuroscience Institute (China-INI), Xuanwu Hospital- Capital Medical University, Beijing, China
Wang Ning

Department of Neurosurgery, China International Neuroscience Institute (China-INI), Xuanwu Hospital- Capital Medical University, Beijing, China

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APA Style

Isabella Opoku, Lin Qin Tang, Lidan Jiang, Dan Dan Wang, Xu Yueqiao, et al. (2021). Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review. Journal of Surgery, 9(4), 193-198. https://doi.org/10.11648/j.js.20210904.19

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ACS Style

Isabella Opoku; Lin Qin Tang; Lidan Jiang; Dan Dan Wang; Xu Yueqiao, et al. Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review. J. Surg. 2021, 9(4), 193-198. doi: 10.11648/j.js.20210904.19

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AMA Style

Isabella Opoku, Lin Qin Tang, Lidan Jiang, Dan Dan Wang, Xu Yueqiao, et al. Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review. J Surg. 2021;9(4):193-198. doi: 10.11648/j.js.20210904.19

Copy | Download

@article{10.11648/j.js.20210904.19,
  author = {Isabella Opoku and Lin Qin Tang and Lidan Jiang and Dan Dan Wang and Xu Yueqiao and Ling Feng and Wang Ning},
  title = {Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review},
  journal = {Journal of Surgery},
  volume = {9},
  number = {4},
  pages = {193-198},
  doi = {10.11648/j.js.20210904.19},
  url = {https://doi.org/10.11648/j.js.20210904.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20210904.19},
  abstract = {Background: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a serious and uncommon complication which can be developed months or years after a Kidney transplant. Immunosuppressive agents administered before and after transplantation to minimize the chances of allograft rejection has proved to be a double-edged sword that puts the host at risk of infectious, neoplastic and vascular diseases, including PCNS-PTLD. The immunosuppressive therapy leads to decreased innate malignant and viral immune surveillance and this has been shown to play a role in lymphoproliferative diseases after transplantation. In most cases, PCNS-PTLD is Epstein–Barr virus related. Case Description: A 60-year-old female with history of kidney transplant presented to the emergency room with history of low fever, dizziness nausea and vomiting for 1 month. MRI and CT scans showed a mass cerebellar lesion and a biopsy revealed Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD). Conclusion: This case highlights the need for a careful long-term follow up of patients with kidney transplant. PCNS-PTLD represents a continuing long-term risk after transplantation, although less common. This case report supports observational data that suggests that peripheral blood screening for EBV DNA does not seem helpful for identification of PCNS-PTLD. Suspicion of PCNS PTLD should be considered when patients with long-term history of kidney transplant present neurological complaints.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Late Primary B Cell Cerebral Lymphoma After Kidney Transplant: A Case Report and Literature Review
AU  - Isabella Opoku
AU  - Lin Qin Tang
AU  - Lidan Jiang
AU  - Dan Dan Wang
AU  - Xu Yueqiao
AU  - Ling Feng
AU  - Wang Ning
Y1  - 2021/08/02
PY  - 2021
N1  - https://doi.org/10.11648/j.js.20210904.19
DO  - 10.11648/j.js.20210904.19
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 193
EP  - 198
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20210904.19
AB  - Background: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a serious and uncommon complication which can be developed months or years after a Kidney transplant. Immunosuppressive agents administered before and after transplantation to minimize the chances of allograft rejection has proved to be a double-edged sword that puts the host at risk of infectious, neoplastic and vascular diseases, including PCNS-PTLD. The immunosuppressive therapy leads to decreased innate malignant and viral immune surveillance and this has been shown to play a role in lymphoproliferative diseases after transplantation. In most cases, PCNS-PTLD is Epstein–Barr virus related. Case Description: A 60-year-old female with history of kidney transplant presented to the emergency room with history of low fever, dizziness nausea and vomiting for 1 month. MRI and CT scans showed a mass cerebellar lesion and a biopsy revealed Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD). Conclusion: This case highlights the need for a careful long-term follow up of patients with kidney transplant. PCNS-PTLD represents a continuing long-term risk after transplantation, although less common. This case report supports observational data that suggests that peripheral blood screening for EBV DNA does not seem helpful for identification of PCNS-PTLD. Suspicion of PCNS PTLD should be considered when patients with long-term history of kidney transplant present neurological complaints.
VL  - 9
IS  - 4
ER  -

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