Effect of Honey versus Icodextrin on Adhesion Reformation after Adhesiolysis: an Experimental Study in Rats
Journal of Surgery
Volume 4, Issue 1-1, January 2016, Pages: 5-10
Received: Aug. 6, 2015; Accepted: Aug. 7, 2015; Published: Sep. 8, 2015
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Aly Saber, Port-Fouad General Hospital, Port-Fouad, Egypt
Mohammed H. Shekidef, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Ismailia, Suez Canal University
Aya Aly Saber, Port-Fouad General Hospital, Port-Fouad, Egypt
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Introduction: Although the process of de novo adhesion formation after operation has been fairly well established, adhesion reformation in a previously affected zone is still poorly understood. Honey was proved effective as an anti-adhesive agent in experimental animals. The aim of the present experimental study is to investigate the effect of HONEY on adhesion reformation prevention when compared with ICODEXTRIN in rats. Materials & Methods: 75 healthy male Sprague–Dawley rats having average weight250–300 g were divided into three groups for study: [25 rats for each], Honey, Icodextrin and control groups. Laparotomy was done carefully for not to disturb any adhesion could be attached to the previous laparotomy incision. Any adhesion band was dissected and divided gently and smoothly with sharp maneuver using fine surgical scissors. In case of groups A and B, three ml of Honey and Icodextrin were instillated, using sterile syringes; into the abdominal cavity before completing laparotomy wound closure to prevent escape of the material outside the peritoneal cavity. Results: Total adhesion score among the three groups showed statistically significant difference using the ANOVA test but when comparing group A and B,the difference is considered to be not statistically significant. Conclusion: Both icodextrin and honey has beneficial effect on reduction of the extent and severity of intraperitoneal adhesion reformation in our rat model for colonic anastomoses. Honey surpasses icodextrin regarding the total adhesion score and the score per animal.
Adhesion Reformation, Honey, Icodextrin, Rats
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Aly Saber, Mohammed H. Shekidef, Aya Aly Saber, Effect of Honey versus Icodextrin on Adhesion Reformation after Adhesiolysis: an Experimental Study in Rats, Journal of Surgery. Special Issue: Abdominal Surgery: Toward the Best. Vol. 4, No. 1-1, 2016, pp. 5-10. doi: 10.11648/j.js.s.2016040101.12
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