Journal of Surgery

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Sarcomatoid Renal Cell Carcinoma Arisen after the Renal Allograft from Donation after Citizen Death: A Case Report and Literature Review

Received: 28 August 2016    Accepted: 12 September 2016    Published: 08 October 2016
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Abstract

The aim of this study was to discuss the causes and preventions of sacromatoid renal cell carcinoma (SRCC) after renal allograft from donation after citizens death (DCD). It was reported on a 45-year-old male patient had undergone renal transplantation in other hospital because of chronic renal insufficiency uraemia in August of 2014. Two months later, lesions found in the renal parenchyma in the right iliac fossa via the color doppler ultrasound. The area of renal transplantation was bulged with tenderness. The renal dysfunction and microscopic haematuria were found. The review color doppler ultrasound and CT showed that the allograft kidney is enlarged rapidly. On 22nd December 2014, a surgical exploration was performed. An irregular and hard mass within the parenchyma of engrafted kidney was found, which was considered as malignant. The nephrectomy of the renal allograft was performed in the operation. First postoperative day, his condition was deteriorating rapidly. Finally, the patient died of cardiac functional failure. The tumor was pathologically diagnosed as sacromatoid renal cell carcinoma (SRCC). SRCC found in the donor allograft kidney is highly malignant and poorly prognosis. The repeated imaging investigations are necessary to exclude the hidden trouble of tumors, such as SRCC. Postoperative immunosuppressive regimens should be modified and the screening program of renal tumor for the early control and prevention should be strengthen.

DOI 10.11648/j.js.20160405.16
Published in Journal of Surgery (Volume 4, Issue 5, October 2016)
Page(s) 122-125
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Organ Donation, Renal Allograft, Sarcomatoid Renal Cell Carcinoma

References
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[2] Hwang JK, Moon IS, Kim JI. Malignancies after kidney transplantation: a 40-year single-center experience in Korea. Transpl Int 2011; 24: 716-21.
[3] Wang Chao, Li Tao, Zhang Jian, Liu Fen, Xie Zelin, Tang Yawang, et al. Trend analysis of malignant tumor after renal transplantation in China. Organ Transplantation 2015; 3: 169-73.
[4] Pedotti P, Cardillo M, Rossini G, Arcuri V, Boschiero L, Caldara R, et al. Incidence of cancer after kidney transplant: results from the North Italy transplant program. Transplantation 2003; 76: 1448-51.
[5] Tillou X, Guleryuz K, Doerfler A, Bensadoun H, Chambade D, Codas R, et al. Nephron sparing surgery for De Novo kidney graft tumor: results from a multicenter national study. American Journal of Transplantation 2014; 14: 2120-5.
[6] Cornelis F, Buy X, André M, Oyen R, Bouffard-Vercelli J, Blandino A, et al. De novo renal tumors arising in kidney transplants: midterm outcome after percutaneous thermal ablation. Radiology 2011; 260: 900-7.
[7] Schulz TF. Cancer and viral infections in immunocompromised individuals. International journal of cancer 2009; 125: 1755-63.
[8] Nalesnik MA, Ison MG. Organ transplantation from deceased donors with cancer: is it safe? Open Access Surgery 2011; 4: 11-20.
[9] Wein AJ, Kavoussi LR,Novick AC,Partin AW, Peters CA. Renal Tumors.In: Guo Yinglu, Zhou Liqun, editor. Campbell-Walsh Urology, 9th ed. Peking: Peking University Medical Press; 2009.p.1651-773.
[10] Kauffman H M, Cherikh W S, McBride M A, et al. Deceased donors with a past history of malignancy: an organ procurement and transplantation network/united network for organ sharing update. Transplantation, 2007, 84 (2): 272-274.
[11] Penn I. Primary kidney tumors before and after renal transplantation.T ransplantation, 1995, 59 (4): 480-485.
[12] De Peralta-Venturina M, Moch H, Amin M, Tamboli P, Hailemariam S, Mihatsch M, et al. Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. The American journal of surgical pathology 2001; 25: 275-84.
[13] Ro JY, Ayala AG, Sella A, Samuels ML, Swanson DA. Sarcomatoid renal cell carcinoma: clinicopathologic. A study of 42 cases. Cancer 1987; 59: 516-26.
[14] Akhtar M, Tulbah A, Kardar A H, Ali MA. Sarcomatoid renal cell carcinoma: the chromophobe connection. The American journal of surgical pathology 1997; 21: 1188-95.
[15] Xu Hongmin, Li Weihua, Li Hongfen. The expression of cytokeratin and vimentin immunohistochemistry in renal cell carcinoma. Medical Journal of Chinese People's Liberation Army 1988; 3:177-9.
[16] Luo Ming, Qiu Jian-xin. Mammalian target of rapamycin inhibitors in the treatment of malignancy after organ transplantation. World clinical drugs 2009:02:65-71.
Author Information
  • Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou, China

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    Wu Yonglu, Chen Jie, Yuan Boxiang, Su Zexuan, Ding Hongwen, et al. (2016). Sarcomatoid Renal Cell Carcinoma Arisen after the Renal Allograft from Donation after Citizen Death: A Case Report and Literature Review. Journal of Surgery, 4(5), 122-125. https://doi.org/10.11648/j.js.20160405.16

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    ACS Style

    Wu Yonglu; Chen Jie; Yuan Boxiang; Su Zexuan; Ding Hongwen, et al. Sarcomatoid Renal Cell Carcinoma Arisen after the Renal Allograft from Donation after Citizen Death: A Case Report and Literature Review. J. Surg. 2016, 4(5), 122-125. doi: 10.11648/j.js.20160405.16

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    AMA Style

    Wu Yonglu, Chen Jie, Yuan Boxiang, Su Zexuan, Ding Hongwen, et al. Sarcomatoid Renal Cell Carcinoma Arisen after the Renal Allograft from Donation after Citizen Death: A Case Report and Literature Review. J Surg. 2016;4(5):122-125. doi: 10.11648/j.js.20160405.16

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  • @article{10.11648/j.js.20160405.16,
      author = {Wu Yonglu and Chen Jie and Yuan Boxiang and Su Zexuan and Ding Hongwen and Shi Liping and Wang Shaojiang},
      title = {Sarcomatoid Renal Cell Carcinoma Arisen after the Renal Allograft from Donation after Citizen Death: A Case Report and Literature Review},
      journal = {Journal of Surgery},
      volume = {4},
      number = {5},
      pages = {122-125},
      doi = {10.11648/j.js.20160405.16},
      url = {https://doi.org/10.11648/j.js.20160405.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.js.20160405.16},
      abstract = {The aim of this study was to discuss the causes and preventions of sacromatoid renal cell carcinoma (SRCC) after renal allograft from donation after citizens death (DCD). It was reported on a 45-year-old male patient had undergone renal transplantation in other hospital because of chronic renal insufficiency uraemia in August of 2014. Two months later, lesions found in the renal parenchyma in the right iliac fossa via the color doppler ultrasound. The area of renal transplantation was bulged with tenderness. The renal dysfunction and microscopic haematuria were found. The review color doppler ultrasound and CT showed that the allograft kidney is enlarged rapidly. On 22nd December 2014, a surgical exploration was performed. An irregular and hard mass within the parenchyma of engrafted kidney was found, which was considered as malignant. The nephrectomy of the renal allograft was performed in the operation. First postoperative day, his condition was deteriorating rapidly. Finally, the patient died of cardiac functional failure. The tumor was pathologically diagnosed as sacromatoid renal cell carcinoma (SRCC). SRCC found in the donor allograft kidney is highly malignant and poorly prognosis. The repeated imaging investigations are necessary to exclude the hidden trouble of tumors, such as SRCC. Postoperative immunosuppressive regimens should be modified and the screening program of renal tumor for the early control and prevention should be strengthen.},
     year = {2016}
    }
    

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    AU  - Wu Yonglu
    AU  - Chen Jie
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    JO  - Journal of Surgery
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    AB  - The aim of this study was to discuss the causes and preventions of sacromatoid renal cell carcinoma (SRCC) after renal allograft from donation after citizens death (DCD). It was reported on a 45-year-old male patient had undergone renal transplantation in other hospital because of chronic renal insufficiency uraemia in August of 2014. Two months later, lesions found in the renal parenchyma in the right iliac fossa via the color doppler ultrasound. The area of renal transplantation was bulged with tenderness. The renal dysfunction and microscopic haematuria were found. The review color doppler ultrasound and CT showed that the allograft kidney is enlarged rapidly. On 22nd December 2014, a surgical exploration was performed. An irregular and hard mass within the parenchyma of engrafted kidney was found, which was considered as malignant. The nephrectomy of the renal allograft was performed in the operation. First postoperative day, his condition was deteriorating rapidly. Finally, the patient died of cardiac functional failure. The tumor was pathologically diagnosed as sacromatoid renal cell carcinoma (SRCC). SRCC found in the donor allograft kidney is highly malignant and poorly prognosis. The repeated imaging investigations are necessary to exclude the hidden trouble of tumors, such as SRCC. Postoperative immunosuppressive regimens should be modified and the screening program of renal tumor for the early control and prevention should be strengthen.
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