Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds.
| Published in | Journal of Surgery (Volume 8, Issue 6) |
| DOI | 10.11648/j.js.20200806.13 |
| Page(s) | 184-189 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Wound Healing, Insulin, Growth Factor Wounds and Injuries, Difficult Wound Healing, Insulin Therapy, Growth Factors
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APA Style
Neide Kalil Gaspar, Antonio Pedro de Andrade Gaspar. (2020). Difficult to Heal Wounds Intralesional Insulin Therapy Trial. Journal of Surgery, 8(6), 184-189. https://doi.org/10.11648/j.js.20200806.13
ACS Style
Neide Kalil Gaspar; Antonio Pedro de Andrade Gaspar. Difficult to Heal Wounds Intralesional Insulin Therapy Trial. J. Surg. 2020, 8(6), 184-189. doi: 10.11648/j.js.20200806.13
AMA Style
Neide Kalil Gaspar, Antonio Pedro de Andrade Gaspar. Difficult to Heal Wounds Intralesional Insulin Therapy Trial. J Surg. 2020;8(6):184-189. doi: 10.11648/j.js.20200806.13
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Download@article{10.11648/j.js.20200806.13,
author = {Neide Kalil Gaspar and Antonio Pedro de Andrade Gaspar},
title = {Difficult to Heal Wounds Intralesional Insulin Therapy Trial},
journal = {Journal of Surgery},
volume = {8},
number = {6},
pages = {184-189},
doi = {10.11648/j.js.20200806.13},
url = {https://doi.org/10.11648/j.js.20200806.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20200806.13},
abstract = {Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds.},
year = {2020}
}
TY - JOUR T1 - Difficult to Heal Wounds Intralesional Insulin Therapy Trial AU - Neide Kalil Gaspar AU - Antonio Pedro de Andrade Gaspar Y1 - 2020/11/09 PY - 2020 N1 - https://doi.org/10.11648/j.js.20200806.13 DO - 10.11648/j.js.20200806.13 T2 - Journal of Surgery JF - Journal of Surgery JO - Journal of Surgery SP - 184 EP - 189 PB - Science Publishing Group SN - 2330-0930 UR - https://doi.org/10.11648/j.js.20200806.13 AB - Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds. VL - 8 IS - 6 ER -
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