Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats
American Journal of Clinical and Experimental Medicine
Volume 1, Issue 1, July 2013, Pages: 1-4
Received: Apr. 30, 2013;
Published: Jun. 10, 2013
Views 2904 Downloads 209
Huthman Ibrahim Oluwaseun, Department of Anatomy, Olabisi Onabanjo University, Ogun State Nigeria
Ibrahim Bilikis, Department of Pharmacy, Federal Medical Centre Umuahia, Abia State, Nigeria
Huthman Adebukola Selimot, Department of Analytical Chemistry, Federal Institute of Industrial Research Oshodi (FIIRO), Lagos state, Nigeria
Otulana Jibril, Department of Anatomy, Olabisi Onabanjo University, Ogun State Nigeria
Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.
Huthman Ibrahim Oluwaseun,
Huthman Adebukola Selimot,
Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats, American Journal of Clinical and Experimental Medicine.
Vol. 1, No. 1,
2013, pp. 1-4.
U.S. National Library of Medicine: Drug Information Portal – Amlodipine
Johnson A. D. and Gomes W.R., The testis, Vols. 1-4 Academic Press, 1970.
Trainer T. D, Histology of the normal testis, Vol.11, Am J surg Pathol, 1987, pp. 797.
Carretero O. A., S. Oparil, Essential hypertension. Part I: definition and etiology, Vol.3, Circulation 101, 2000, pp.329–35.
Pierdomenico S.D., M. Di Nicola, A.L. Esposito, Prognostic Value of Different Indices of Blood Pressure Variability in Hypertensive Patients,Vol.22, American Journal of Hypertension, 2009, pp (8):842–7.
Kearney P. M., M. Whelton, K. Reynolds, P. Muntner, P.K. Whelton, J. He, Global burden of hypertension: analysis of worldwide data, Vol.365, Lancet, 2005, pp (9455) 217–23.
Kearney P. M., M. Whelton, K. Reynolds, P.K. Whelton, J. He, Worldwide prevalence of hypertension: A systematic review, Vol.22, J. Hypertens, 2004, pp (1): 11–9.
Burt V. L., P. Whelton, E.J. Roccella,. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey 1991-1995, Vol.525, Hypertension, 1995, pp(3): 305–13.
Burt V. L., J. A. Cutler, M. Higgins, Trends in the prevalence, awareness, treatment, and control of hypertension in the adult US population. Data from the health examination surveys, 1960 to 1991: Vol. 26, Hypertension 1995, pp(1): 60–9.
Ostchega Y., C.F. Dillon, J.P. Hughes, M. Carroll, S. Yoon,. Trends in hypertension prevalence, awareness, treatment, and control in older U.S. adults: data from the National Health and Nutrition Examination Survey 1988 to 2004, Vol.55, Journal of the American Geriatrics Society, 2007 pp(7): 1056–65.
Almeida S.A., J.M. Teófilo, J.A. Anselmo Franci, L.G. Brentegani, T.L. Lamano- Carvalho,. Antireproductive effect of the calcium channel blocker amlodipine in male rats, Vol. 52, Exp Toxicol Pathol. 2000 pp(4): 353-6.
Source: Sandoz product information sheet