Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats
American Journal of Clinical and Experimental Medicine
Volume 1, Issue 1, July 2013, Pages: 1-4
Received: Apr. 30, 2013;
Published: Jun. 10, 2013
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Huthman Ibrahim Oluwaseun, Department of Anatomy, Olabisi Onabanjo University, Ogun State Nigeria
Ibrahim Bilikis, Department of Pharmacy, Federal Medical Centre Umuahia, Abia State, Nigeria
Huthman Adebukola Selimot, Department of Analytical Chemistry, Federal Institute of Industrial Research Oshodi (FIIRO), Lagos state, Nigeria
Otulana Jibril, Department of Anatomy, Olabisi Onabanjo University, Ogun State Nigeria
Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.
Huthman Ibrahim Oluwaseun,
Huthman Adebukola Selimot,
Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats, American Journal of Clinical and Experimental Medicine.
Vol. 1, No. 1,
2013, pp. 1-4.
U.S. National Library of Medicine: Drug Information Portal – Amlodipine
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