Tacrolimus in the Management of Large Facial Patch with Recurring Reversal Reaction: Outcome of a Pilot Clinical Trial Study on 5 Patients
American Journal of Clinical and Experimental Medicine
Volume 2, Issue 4, July 2014, Pages: 86-89
Received: Jul. 28, 2014; Accepted: Aug. 11, 2014; Published: Aug. 20, 2014
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Delwar Hossain, Department of Dermatology and Venereology, University of Science and Technology Chittagong (USTC), Foy’s Lake, Khulsi, Chittagong, Bangladesh
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Background: Inflamed large facial patch, being compromising the appearance and beauty of a patient, is a source of embarrassment and distress, and affects anti-leprosy drive adversely in many ways in the field situation. Its management with oral prednisolone alone, the mainstay of treatment for reversal reaction, proved disappointing. Objective: To see whether topical tacrolimus will be helpful in managing those patients. Methodology: We treated five adult patients with recurring reversal reaction in large facial patch with tacrolimus 0.1% ointment, twice daily and lower dose oral prednisolone for twelve months during March, 2012-February, 2013. Result: Complete remission was achieved in all cases. No side effects of whatsoever was seen in any patient. No recurrence of reaction is seen in any patient till to date. Conclusion: Tacrolimus ointment and lower dose prednisolone was found helpful in managing patients with recurring reversal reaction in large facial patch.
Leprosy, Reversal Reaction, Reacting Facial Patch, Management, Tacrolimus and Prednisolone
To cite this article
Delwar Hossain, Tacrolimus in the Management of Large Facial Patch with Recurring Reversal Reaction: Outcome of a Pilot Clinical Trial Study on 5 Patients, American Journal of Clinical and Experimental Medicine. Vol. 2, No. 4, 2014, pp. 86-89. doi: 10.11648/j.ajcem.20140204.16
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