The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes
American Journal of Clinical and Experimental Medicine
Volume 2, Issue 5, September 2014, Pages: 106-116
Received: Sep. 26, 2014; Accepted: Oct. 9, 2014; Published: Oct. 20, 2014
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Authors
Nurdan Tatar, Iskenderun State Hospital, Department of Pathology, Hatay, Turkey
Serdar Yanık, Iskenderun State Hospital, Department of Pathology, Hatay, Turkey
Ayse Neslin Akkoca, Iskenderun State Hospital ,Department of Family Medicine, Hatay, Turkey
Zeynep Tugba Ozdemir, Bozok University Faculty of Medicine, Department of Internal Medicine, Yozgat, Turkey
Mustafa Calıskan, Ankara Dışkapı Yıldırım Beyazıt Research Hospital, Department of Endocrinology, Ankara, Turkey
Didem Sozutek, Iskenderun State Hospital, Department of Internal Medicine, Hatay, Turkey
Pınar Atasoy, Kırıkkale University Faculty of Medicine, Department of Pathology, Kırıkkale, Turkey
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Abstract
Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.
Keywords
Celiac Disease (CD), İncreased İntraepithelial Lymphocytes (İEL),Non-Spesific Duedonitis(NSD), FAS, FASL
To cite this article
Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, Didem Sozutek, Pınar Atasoy, The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes, American Journal of Clinical and Experimental Medicine. Vol. 2, No. 5, 2014, pp. 106-116. doi: 10.11648/j.ajcem.20140205.14
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