American Journal of Clinical and Experimental Medicine

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Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver

Received: 31 December 2014    Accepted: 15 January 2015    Published: 28 January 2015
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Abstract

An important CT-characteristic at a diagnostic of liver tumors is the determination of its vascularity. To study the characteristics of blood tissue of hepatocellular carcinoma (HCC) with different degrees of differentiation by CT. The work is based on the clinical and morphological comparisons performed in 55 patients (34 men and 21 women aged 15-83 years) with hepatocellular carcinoma (HCC) without accompanying liver cirrhosis. In the preoperative stage all patients was carried spiral computed tomography (CT) with bolus contrast enhancement (on the four phases of the study). Was evaluated parameters of CT density and degree of nodes HCC vascularization. Morphologic study of histological preparations of operation material from 16 patients was diagnosed high-differentiated, 33 - moderately differentiated, and 6 - poorly differentiated HCC. At the immunohistochemical preparations with reaction to CD34 was determined by the number and the total cross-sectional area of vessels in sight of HCC tissue. The maximum values of CT density in the arterial phase were observed at the nodes moderately differentiated HCC. In the venous phase the greatest values of density as well as the venous increase was registered in high-differentiated HCC. The most vascularised (hypervascular) tumor is high-differentiated HCC, and the least vascularized - poorly differentiated HCC by CT. At morphometric study of the maximum values of the number and the total cross-sectional area of the blood vessels are installed in high-differentiated HCC tissues, the minimum - in the tissue of low-grade HCC. CT with bolus contrast enhancement allows studying the characteristics of blood supply of HCC varying degrees of differentiation. Determine the true measure of total CT-vascularization of the tumor tissue must be done with consideration of the increase concentration difference coefficient (ICDC).

DOI 10.11648/j.ajcem.20150301.13
Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 1, January 2015)
Page(s) 24-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hepatocellular Carcinoma, Histological Differentiation, Computed Tomography, Contrast Enhancement, Vascularity

References
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Author Information
  • Department of Radiological Methods of Diagnosis and Treatment, A.V. Vishnevsky Institute of Surgery, Ministry of Health of Russia, Moscow, Russia; Department of Pathology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

  • Department of Radiological Methods of Diagnosis and Treatment, A.V. Vishnevsky Institute of Surgery, Ministry of Health of Russia, Moscow, Russia

  • Department of Pathology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

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  • APA Style

    Ulyana N. Tumanova, Grigoriy G. Karmazanovsky, Alexander I. Shchyogolev. (2015). Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver. American Journal of Clinical and Experimental Medicine, 3(1), 24-31. https://doi.org/10.11648/j.ajcem.20150301.13

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    ACS Style

    Ulyana N. Tumanova; Grigoriy G. Karmazanovsky; Alexander I. Shchyogolev. Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver. Am. J. Clin. Exp. Med. 2015, 3(1), 24-31. doi: 10.11648/j.ajcem.20150301.13

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    AMA Style

    Ulyana N. Tumanova, Grigoriy G. Karmazanovsky, Alexander I. Shchyogolev. Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver. Am J Clin Exp Med. 2015;3(1):24-31. doi: 10.11648/j.ajcem.20150301.13

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  • @article{10.11648/j.ajcem.20150301.13,
      author = {Ulyana N. Tumanova and Grigoriy G. Karmazanovsky and Alexander I. Shchyogolev},
      title = {Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {3},
      number = {1},
      pages = {24-31},
      doi = {10.11648/j.ajcem.20150301.13},
      url = {https://doi.org/10.11648/j.ajcem.20150301.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20150301.13},
      abstract = {An important CT-characteristic at a diagnostic of liver tumors is the determination of its vascularity. To study the characteristics of blood tissue of hepatocellular carcinoma (HCC) with different degrees of differentiation by CT. The work is based on the clinical and morphological comparisons performed in 55 patients (34 men and 21 women aged 15-83 years) with hepatocellular carcinoma (HCC) without accompanying liver cirrhosis. In the preoperative stage all patients was carried spiral computed tomography (CT) with bolus contrast enhancement (on the four phases of the study). Was evaluated parameters of CT density and degree of nodes HCC vascularization. Morphologic study of  histological preparations of operation material from 16 patients was diagnosed high-differentiated, 33 - moderately differentiated, and 6 - poorly differentiated HCC. At the immunohistochemical preparations with reaction to CD34 was determined by the number and the total cross-sectional area of vessels in sight of HCC tissue. The maximum values of CT density in the arterial phase were observed at the nodes moderately differentiated HCC. In the venous phase the greatest values of density as well as the venous increase was registered in high-differentiated HCC. The most vascularised (hypervascular) tumor is high-differentiated HCC, and the least vascularized - poorly differentiated HCC by CT. At morphometric study of the maximum values of the number and the total cross-sectional area of the blood vessels are installed in high-differentiated HCC tissues, the minimum - in the tissue of low-grade HCC. CT with bolus contrast enhancement allows studying the characteristics of blood supply of HCC varying degrees of differentiation. Determine the true measure of total CT-vascularization of the tumor tissue must be done with consideration of the increase concentration difference coefficient (ICDC).},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver
    AU  - Ulyana N. Tumanova
    AU  - Grigoriy G. Karmazanovsky
    AU  - Alexander I. Shchyogolev
    Y1  - 2015/01/28
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajcem.20150301.13
    DO  - 10.11648/j.ajcem.20150301.13
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 24
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20150301.13
    AB  - An important CT-characteristic at a diagnostic of liver tumors is the determination of its vascularity. To study the characteristics of blood tissue of hepatocellular carcinoma (HCC) with different degrees of differentiation by CT. The work is based on the clinical and morphological comparisons performed in 55 patients (34 men and 21 women aged 15-83 years) with hepatocellular carcinoma (HCC) without accompanying liver cirrhosis. In the preoperative stage all patients was carried spiral computed tomography (CT) with bolus contrast enhancement (on the four phases of the study). Was evaluated parameters of CT density and degree of nodes HCC vascularization. Morphologic study of  histological preparations of operation material from 16 patients was diagnosed high-differentiated, 33 - moderately differentiated, and 6 - poorly differentiated HCC. At the immunohistochemical preparations with reaction to CD34 was determined by the number and the total cross-sectional area of vessels in sight of HCC tissue. The maximum values of CT density in the arterial phase were observed at the nodes moderately differentiated HCC. In the venous phase the greatest values of density as well as the venous increase was registered in high-differentiated HCC. The most vascularised (hypervascular) tumor is high-differentiated HCC, and the least vascularized - poorly differentiated HCC by CT. At morphometric study of the maximum values of the number and the total cross-sectional area of the blood vessels are installed in high-differentiated HCC tissues, the minimum - in the tissue of low-grade HCC. CT with bolus contrast enhancement allows studying the characteristics of blood supply of HCC varying degrees of differentiation. Determine the true measure of total CT-vascularization of the tumor tissue must be done with consideration of the increase concentration difference coefficient (ICDC).
    VL  - 3
    IS  - 1
    ER  - 

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