Thyroid Functions and Thyroid Auto-Antibodies in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 5, September 2015, Pages: 207-212
Received: Jul. 29, 2015; Accepted: Aug. 12, 2015; Published: Aug. 21, 2015
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Authors
Satya Narayan Chaudhary, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Shahana Akther Rahman, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Mohammad Imnul Islam, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Suraiya Begum, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Manik Kumar Talukdar, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Md Israque Hossain Ansari, National Institute of Nuclear Medicine & Allied Sciences (NINMAS), Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mizanul Hasan, National Institute of Nuclear Medicine & Allied Sciences (NINMAS), Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
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Abstract
Background: Thyroid dysfunction may be associated in pediatric SLE cases and may present as euthyroid, subclinical hypothyroid, hypothyroid or hyperthyroid states. Aim of this study was to assess thyroid functions (serum T3, T4, TSH) and thyroid antibodies (anti-thyroid Peroxidase and anti-thyroglobulin) in pediatric SLE patients. Methods: It was a cross sectional study. Pediatric SLE (pSLE) patients who fulfilled the American College of Rheumatology 1997 revised classification criteria for SLE were enrolled in this study. Sixteen apparently healthy children were enrolled in the study as reference group. Disease activity was measured by systemic lupus erythematosus disease activity index (SLEDAI). Serum T3, T4, TSH and auto-antibodies including, anti-thyroid peroxidase (anti-TPO) and anti- thyroglobulin (anti-TG) were measured by radio-immuno assay (RIA) method in the National Institute of Nuclear Medicine & Allied Sciences, BSMMU, Dhaka. Data were analyzed by SPSS for window version 16 which included descriptive statistics, Man-Whitney test and Fisher exact test. Results: Among a total number of 50 pSLE cases, 41 (82%) cases had euthyroid state, 4 had subclinical hypothyroidism, 3 had hypothyroidism and 2 patients had euthyroid sick syndrome. All the cases of reference group were in euthyroid state. Anti-thyroid peroxidase (TPO) antibody was positive in 24 pSLE cases and anti-thyroglobulin (TG) antibody was positive in 16 patients. Thyroid disorder was present in 9 cases and 7 of them had positive anti-TPO antibody. Conclusion: Thyroid disorders and presence of thyroid auto antibodies were common in pSLE patients. Anti-TPO positivity was more common than Anti-TG positivity
Keywords
Pediatric SLE, Triidothyronine, Thyroxine, TSH, Anti- thyroid Peroxidase, Anti- thyroglobulin
To cite this article
Satya Narayan Chaudhary, Shahana Akther Rahman, Mohammad Imnul Islam, Suraiya Begum, Manik Kumar Talukdar, Md Israque Hossain Ansari, Mizanul Hasan, Thyroid Functions and Thyroid Auto-Antibodies in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh, American Journal of Clinical and Experimental Medicine. Vol. 3, No. 5, 2015, pp. 207-212. doi: 10.11648/j.ajcem.20150305.12
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